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Journals / Üroonkoloji Bülteni / 2019 / Cilt: 18 - Sayı: 1

Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?

Aykut Buğra ŞENTÜRK
Musa EKİCİ
Cemil AYDIN
Mehmet Murat BAYKAM
Tuncay TAŞ
Ersan ARDA
Basri ÇAKIROĞLU
Pages
6–9
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our results indicate that a combination of NLR and RDW can help clinicians predict lamina propria invasion in non-muscle-invasive bladder tumors.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To determine the role of preoperative neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width (RDW) in predicting lamina propria invasion in bladder cancer.
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Key Findings & Data:The patients were divided into those with Ta tumors (group 1: n=36) and those with T1 tumors (group 2: n=52).
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Conclusion & Impact:Our results indicate that a combination of NLR and RDW can help clinicians predict lamina propria invasion in non-muscle-invasive bladder tumors.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objective: To determine the role of preoperative neutrophil-to-lymphocyte ratio (NLR) and red cell distribution width (RDW) in predicting lamina propria invasion in bladder cancer. Materials and Methods: Eighty-eight patients with non-muscle-invasive bladder cancer were evaluated retrospectively. The patients were divided into those with Ta tumors (group 1: n=36) and those with T1 tumors (group 2: n=52). For each patient, white blood cell, neutrophil, and leukocyte counts and RDW values were evaluated. Results: NLR was significantly lower in patients with Ta tumors. In addition, NLR below 3.22 was associated with 80.6% probability of Ta disease. RDW sensitivity in Ta non-muscle-invasive bladder tumors was much higher compared to T1 tumors. RDW below 15.35 was associated with 94.4% probability of Ta disease. Conclusion: NLR and RDW are basic blood parameters that physicians can assess easily. Our results indicate that a combination of NLR and RDW can help clinicians predict lamina propria invasion in non-muscle-invasive bladder tumors.

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Cite This Article

ŞENTÜRK, A. B., EKİCİ, M., AYDIN, C., BAYKAM, M. M., TAŞ, T., ARDA, E., ÇAKIROĞLU, B. (2019). Predicting Lamina Propria Invasion in Patients with Nonmuscle-invasive Bladder Cancer: Do RDW and NLR Really Work?. Üroonkoloji Bülteni, Cilt: 18 - Sayı: 1, 6–9. https://ajindex.com/articles/334382

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References (12)

  1. Tiu A, Jenkins LC, Soloway MS. Active surveillance for low-risk bladder cancer. Urol Oncol 2014;32:33. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin 2016;66:7-30.
  2. Burger M, Catto JW, Dalbagni G, et al. Epidemiology and risk factors of urothelial bladder cancer. Eur Urol 2013;63:234-241.
  3. Isharwal S, Konety B. Non-muscle invasive bladder cancer risk stratification. Indian J Urol 2015;31:289-296.
  4. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflamation. Nature 2008;454:436-444.
  5. McMillan DC, Canna K, McArdle CS. Systemic inflammatory response predicts survival following curative resection of colorectal cancer. Br J Surg 2003;90:215-219.
  6. Kum RO, Ozcan M, Baklaci D, et al. Elevated neutrophil-tolymphocyte ratio in squamous cell carcinoma of larynx compared to benign and precancerous laryngeal lesions. Asian Pac J Cancer Prev 2014;15:7351-7355.
  7. Duzlu M, Karamert R, Tutar H, et al. Neutrophil-lymphocyte ratio findings and larynx carcinoma: a preliminary study in Turkey. Asian Pac J Cancer Prev 2015;16:351-354.
  8. Mano R, Baniel J, Shoshany O, et al. Neutrophil-to-lymphocyte ratio predicts progression and recurrence of non-muscle-invasive bladder cancer. Urol Oncol 2015;33:67. Ceylan C, Doluoglu OG, Keleş I, et al. Importance of the neutrophilto- lymphocyte ratio in muscle-invasive and non-muscle invasive bladder tumors. Urologia 2014;81:120-124.
  9. Krane LS, Richards KA, Kader AK, et al. Preoperative neutrophil/ lymphocyte ratio predicts overall survival and extravesical disease in patients undergoing radical cystectomy. J Endourol 2013;27:1046-1050.
  10. Riedl J, Posch F, Königsbrügge O, et al. Red cell distribution width and other redblood cell parameters in patients with cancer: association with risk of venous thromboembolism and mortality. PLoS One 2014;9:e111440. Yilmaz A, Malya F, Ozturk G, et al. Effect of pre-operative red blood cell distribution on cancer stage and morbidity rate in patients with pancreatic cancer. Int J Clin Exp Med 2014;7:3072-3075. Busato Júnior WF, Almeida GL, Ribas CA, et al. EORTC Risk Model to Predict Progression in Patients With Non-Muscle-Invasive Bladder Cancer: Is It Safe to Use in Clinical Practice? Clin Genitourin Cancer 2016;14:176-182.
  11. Cimen HI, Halis F, Saglam HS, Gokce A. Can neutrophil to lymphocyte ratio predict lamina propria invasion in patients with non muscle invasive bladder cancer? Int Braz J Urol 2017;43:67-72.
  12. Cheng YC, Huang CN, Wu WJ, et al. The Prognostic Significance of Inflamm