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Journals / Van Tıp Dergisi / 2013 / Cilt: 20 - Sayı: 3

New roles of mast cells in cancer and angiogenesis

Mast hücrelerinin kanser ve anjiyogenezde Yeni tanımlanan rolleri

AZİZE YASEMİN GÖKSU EROL
Pages
189–193
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review, the importance of mast cells in cancer, their cytotoxic and phagocytotic effects, and their relationship with angiogenesis will be discussed in the light of the recent literature and our study results.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Mast cells have many functions in addition to their well–known roles in allergy and parasitic infestations and involve in various events such as bacterial infections, inflammation, angiogenesis, tissue repair, and wound healing.
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Key Findings & Data:Besides, mast cells have important roles in cancer.
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Conclusion & Impact:In this review, the importance of mast cells in cancer, their cytotoxic and phagocytotic effects, and their relationship with angiogenesis will be discussed in the light of the recent literature and our study results.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Mast cells have many functions in addition to their well–known roles in allergy and parasitic infestations and involve in various events such as bacterial infections, inflammation, angiogenesis, tissue repair, and wound healing. Besides, mast cells have important roles in cancer. Potential mast cell effects on tumor growth can be categorized as either direct effects on tumor cells, such as mast cell–mediated cytotoxicity, or indirect effects such as mast cell– directed angiogenesis, tissue remodelling of the neighbouring environment and immune cell recruitment. In this review, the importance of mast cells in cancer, their cytotoxic and phagocytotic effects, and their relationship with angiogenesis will be discussed in the light of the recent literature and our study results.

Özet

Mast hücre (MH)’lerinin alerji ve parazit infestasyonlarındaki iyi bilinen rollerine ek olarak birçok fonksiyonları bulunmaktadır ve bakteriyel enfeksiyonlar, inflamasyon, anjiyogenez, doku tamiri ve yara iyileşmesi gibi birçok farklı olayda rol oynadıkları bilinmektedir. Ayrıca MH’nin kanserde de önemli rolleri mevcuttur. MH’lerin tümör büyümesindeki potansiyel etkileri şu şekilde kategorize edilebilir: MH ile düzenlenen sitotoksisite gibi tümör hücrelerine direkt etkileri, yada MH ile düzenlenen anjiyogenez, komşu çevre dokusunda remodeling ve immün hücrelerin o bölgeye çekilmesi gibi indirekt etkileri. Bu yazımızda, MH’lerin kanserdeki önemi, sitotoksik ve fagositotik etkileri ve anjiyogenez ile ilişkileri son literatür verileri ve kendi çalışma sonuçlarımız ışığında tartışılacaktır.

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Cite This Article

EROL, A. Y. G. (2013). New roles of mast cells in cancer and angiogenesis. Van Tıp Dergisi, Cilt: 20 - Sayı: 3, 189–193. https://ajindex.com/articles/334192

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