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Journals / Van Tıp Dergisi / 2015 / Cilt: 22 - Sayı: 2

Does chronic Prostatitis affect Prostate Specific Antigen levels in the same age group patients?

Aynı Yaş Grubu Hastalarda Kronik Prostatit Prostat Spesifik Antigen Düzeylerini Etkiler mi?

İBRAHİM KELEŞ
Soner COBAN
ERDAL BENLİ
MUSTAFA KARALAR
Ahmed Ömer HALAT
Cavit CEYLAN
Pages
104–107
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Although benign prostatic biopsy, PSA elevation still continues in patients with normal digital rectal examination, chronic prostatitis focus should be kept in mind in pathological diagnosis of the prostate.

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Objective & Hypothesis:Aim: We aimed to investigate the relationship between chronic prostatitis and prostate spesific antigen in patients who underwent prostate biopsies because of elevated levels of serum prostate specific antigen (PSA).
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Key Findings & Data:Materials and Methods: Between December 2011 and May 2014, records of patients who underwent prostate biopsy because of elevated PSA levels were retrospectively analyzed and 268 patients were included in the study.
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Conclusion & Impact:Conclusion: Although benign prostatic biopsy, PSA elevation still continues in patients with normal digital rectal examination, chronic prostatitis focus should be kept in mind in pathological diagnosis of the prostate.
🔬Design:Research Article
📍Scope:2011 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: We aimed to investigate the relationship between chronic prostatitis and prostate spesific antigen in patients who underwent prostate biopsies because of elevated levels of serum prostate specific antigen (PSA). Materials and Methods: Between December 2011 and May 2014, records of patients who underwent prostate biopsy because of elevated PSA levels were retrospectively analyzed and 268 patients were included in the study. Prostate cancer patients who previously underwent transurethral interventions or surgical history were excluded from the study. Patients were divided into 2 groups according to histopathological examination: group 1:Benign Prostatic Hyperplasia (BPH) and group 2:BPH+chronic prostatitis. 185(69%) patients constituted the first group, while 83(31%) patients the second group. The relationship between serum total PSA, free PSA, free/total PSA, age, prostate volume and PSA density was investigated. Results: Of the patients in this study, the mean values of age, total PSA, free PSA, and prostatic volume were 65.17±7.99 years, 10.98±11.23 ng/ml, 2.25±2.35 ng/ml, 60.29±31.6 cc respectively. Both groups were similar in age, prostate volumes, free PSA and free/total PSA ratio. However, total PSA values and PSA density were significantly higher in chronic prostatitis group (p=0.016, p=0.007). Conclusion: Although benign prostatic biopsy, PSA elevation still continues in patients with normal digital rectal examination, chronic prostatitis focus should be kept in mind in pathological diagnosis of the prostate.

Özet

Amaç: Prostat spesifik antigen (PSA) yüksekliği nedeniyle transrektal prostat biopsisi yapılan hastalarda kronik prostatit ile PSA arasındaki ilişkiyi araştırmak. Materyal ve Metod: Aralık 2011 ve Mayıs 2014 tarihleri arasında alt üriner sistem semptomları (AÜSS) nedeniyle Üroloji polkliniğine başvuran ve prostat biopsisi yapılan hastaların kayıtları retrospektif olarak incelendi ve 268 hasta çalışmaya dahil edildi. Prostat biopsi sonucu kanser gelen hastalar, daha önce geçirilmiş transuretral girişim veya cerrahi öyküsü olan hastalar çalışma dışı bırakıldı. Hastalar patoloji sonuçlarına göre benign prostat hiperplazisi (BPH) ve BPH+kronik prostatit olarak 2 gruba ayrıldı. Patoloji sonucunda 1 ve üzeri korda prostatit tanısı alan hastalar prostatit grubuna dahil edildi. Birinci grupta 185(%69), 2. grupta ise 83(%31) hasta mevcuttu. Hastaların serum total PSA, serbest PSA, serbest/total psa, yaş, prostat volümleri ve PSA dansiteleri arasındaki ilişki araştırıldı. Bulgular: Hastaların ortalama yaş, total psa, serbest psa ve prostat volümleri sırasıyla şu şekildeydi(65.17±7.99, 10.98±11.23, 2.25±2.35, 60.29±31.6) Her iki hasta grubunda yaşlar benzerdi. Prostat volümleri, serbest PSA ve serbest/total PSA oranları arasında istatistiksel olarak anlamlı farklılık yokken, total PSA seviyeleri ve PSA dansiteleri 2. grupta anlamlı olarak yüksekti(p=0.016, p=0.007). Sonuç: Benign prostat patolojisine rağmen halen PSA yüksekliği devam eden ve parmakla rektal muayenesi normal olan hastalarda patolojik tanıda kronik prostatit odakları akılda tutulmalıdır

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Cite This Article

KELEŞ, İ., COBAN, S., BENLİ, E., KARALAR, M., HALAT, A. Ö., CEYLAN, C. (2015). Does chronic Prostatitis affect Prostate Specific Antigen levels in the same age group patients?. Van Tıp Dergisi, Cilt: 22 - Sayı: 2, 104–107. https://ajindex.com/articles/334046

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