AI Summary & Key Takeaways
AI InsightHowever, high platelet distribution width (PDW) may raise the suspicion of malignant lesions with multicentricity.
📌 3 Key Takeaways
Abstract
Objective: Thyroid nodules are the most common disease of the thyroid gland. The main objective of the present study was to provide an answer to one question: "Is it possible to acquire information about malignancy potential of thyroid nodules using the tests readily available at all centers. Materials and Methods: The present study retrospectively reviewed preoperative results of hemogram, biochemical parameters and pathology reports of a total 275 patients, who underwent bilateral total thyroidectomy procedure in the Department of General Surgery at our faculty from 2014 to 2015. Results: The mean age was 47.60 ± 12.79 years. Of patients, 84.7% (233) were females and 14.9% (41%) were males. Of patients that underwent bilateral thyroidectomy, pathologic examination revealed nodular hyperplasia in 180 patients and papillary thyroid cancer (PTC) in 95 patients. TSH levels before surgery were lower in patients with nodular hyperplasia compared to patients with papillary thyroid cancer and the difference was statistically significant (p=0.003). There was no statistically significant difference in hematological parameters measured before surgery between the two groups. However, platelet distribution width was significantly higher in female patients with multicentricity compared to those without multicentricity (p=0.047). Conclusion: The study suggests that hemogram and biochemical tests that are routinely performed in preoperative workup do not easily differentiate malignant lesions from the benign lesions. However, high platelet distribution width (PDW) may raise the suspicion of malignant lesions with multicentricity.
Özet
Amaç: Tiroid nodülleri, tiroidin en sık rastlanılan hastalığıdır. Her merkezde rahatlıkla yapılabilinen tetkiklerle nodüllerin malignite potansiyelleri hakkında bilgi edinmek mümkünmüdür sorusu bu çalışmanın temel amacı olmuştur. Gereç ve Yöntem: Fakültemiz genel cerrahi kliniğinde 2014-2015 yıllarında bilatateral total troidektomi yapılan 275 hastanın preoperatif hemogram ve biyokimyasal parametreleri ve patoloji raporları retrospektif olarak incelenmiştir. Bulgular: Bilateral total tiroidektomi uygulanan olgulardan 180'inin patoloji sonucu nodüler hiperplazi, 95'inin ise papiller tiroid kanseriydi(PTC). Patoloji sonucu nodüler hiperplazi olan olguların cerrahi öncesi bakılan TSH düzeyleri patoloji sonucu papiller kanser gelenlere göre daha düşüktü Bu sonuç istatiksel olarak anlamlı bulundu (p=0.003). İki grup arasında cerrahi öncesi bakılan hematolojik parametreler açısından istatistiksel anlamda fark yoktu. Ancak kadın olgularda multisentrisite olanlarda olmayanlara göre platelet dağılım genişliği istatiksel olarak daha yüksekti (p=0.047). Sonuç: Çalışmanın sonucu göstermiştir ki, preop hazırlıkta rutin yapılan hemogram ve biyokimyasal tetkilerle malign benign ayrımı kolay değildir. Ancak yüksek platelet dağılım genişliği (PDW) ile malign karekterli kitlelerde multisentrisiteden şüphelenmek mümkündür.