AI Summary & Key Takeaways
AI InsightImmunohistochemically some tumor markers such as alpha-fetoprotein (AFP), cytokeratin, smooth muscle actin (SMA), and factor VIII-related antigen (FVIII-Rag) was also studied, and AFP and SMA were found to be positive.
📌 3 Key Takeaways
Abstract
In this report, hepatocellular carcinoma in a 5-years-old female Van cat was described. Grossly, grayish-white nodular masses of 0,1-6 cm in diameters were found in the liver, spleen, lung, kidneys, abdomen and under the skin. Microscopically, tumor cells were arranged as solid, cord-like and trabecular pattern. Neoplastic cells usually had polygonal and vesicular nuclei and had multiple mitotic figures. Immunohistochemically some tumor markers such as alpha-fetoprotein (AFP), cytokeratin, smooth muscle actin (SMA), and factor VIII-related antigen (FVIII-Rag) was also studied, and AFP and SMA were found to be positive.
Özet
Bu raporda, 5 yaşlı dişi bir Van kedisinde belirlenen generalize metastazlı hepatosellüler karsinom olgusu tanımlandı. Makroskobik olarak, karaciğer, dalak, akciğer, böbrekler, karın boşluğu ve deri altında 1mm-6 cm çapına varan, grimtırak-beyaz renkte tümöral nodüller belirlendi. Mikroskobik olarak, tümör hücreleri solid, kordon ve trabeküler yapılar oluşturmuştu. Neoplastik hücreler genellikle poligonal ve veziküler çekirdekli olup çok sayıda mitotik figürlere sahipti. İmmunohistokimyasal olarak tümör markerlerinden alfa-fetoprotein (AFP), sitokeratin, düz kas aktin (SMA) ve faktör VIII'e ilişkin antijen (FVIII-Rag) araştırıldı. Bunlardan AFP ve SMA pozitif bulundu. Tümör, makroskobik, mikroskobik ve immunohistokimyasal özelliklerine göre hepatosellüler karsinom olarak teşhis edildi.