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Journals / Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences / 2004 / Cilt: 20 - Sayı: 2

Are fixed oils of Urtica pilulifera L. protective against carboplatin-induced hepatotoxicity

Urtica pilulifera L. sabit yağı karboplatine'e bağlı hepatotoksisiteye karşı koruyucu mu

HANEFİ ÖZBEK
Mustafa KÖSEM
ENDER ERDOĞAN
Nureddin CENGİZ
FEVZİ ÖZGÖKÇE
Betül SEVER
Pages
53–58
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Fixed oils of Urtica pilulifera L. appears to be equally effective like vitamin C and vitamin E in alleviating carboplatin-induced hepatotoxicity.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study effects of Urtica pilulifera L. extracts against carboplatin-induced hepatotoxicity were investigated in rats.
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Key Findings & Data:The fixed oils of Urtica pilulifera L. group displayed significantly lower alanine aminotransferase, alkaline phosphatase and indirect bilirubin levels compared to the carboplatin group.
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Conclusion & Impact:Fixed oils of Urtica pilulifera L. appears to be equally effective like vitamin C and vitamin E in alleviating carboplatin-induced hepatotoxicity.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:bitki özütü · insan · Urtica

Abstract

In this study effects of Urtica pilulifera L. extracts against carboplatin-induced hepatotoxicity were investigated in rats. Sprague-Dawley rats were divided into five study groups and given isotonic saline solution, carboplatin, carboplatin+fixed oil of Urtica pilulifera L., carboplatin+vitamin C and carboplatin+vitamin E respectively. In histological examination of liver sections none of the groups exhibited pathological changes. The liver injury is evidenced by rise of serum alanine aminotransferase, alkaline phosphatase and indirect bilirubin levels in carboplatin group compared to the controls. The fixed oils of Urtica pilulifera L. group displayed significantly lower alanine aminotransferase, alkaline phosphatase and indirect bilirubin levels compared to the carboplatin group. Vitamin C and E displayed similar biochemical changes as fixed oils of Urtica pilulifera L. Fixed oils of Urtica pilulifera L. appears to be equally effective like vitamin C and vitamin E in alleviating carboplatin-induced hepatotoxicity.

Özet

Bu çalışmada karboplatinin sıçan karaciğerinde yaptığı toksisite üzerine Urtica pilulifera L. sabit yağının koruyucu etkisi araştırıldı. Sprague-Dawley ırkı sıçanlardan oluşturulan beş çalışma grubuna, sırayla serum fizyolojik (kontrol), karboplatin, kar-boplatin+ Urtica pilulifera L. (ısırgan otu) sabit yağı, karboplatin+vitamin C ve karboplatin+vitamin E uygulandı. Çalışma gruplarında karaciğerlere ait histopatolojik bulguya rastlanmadı. Serum alanin aminotransferaz, alkalen fosfataz ve indirekt bilirubin seviyeleri karboplatin grubunda kontrol grubuna göre anlamlı derecede yüksekti ve karboplatinin biyokimyasal enzimler düzeyinde karaciğer hasarı yaptığı şeklinde yorumlandı. Isırgan otu sabit yağının alanin aminotransferaz, alkalen fosfataz ve indirekt bilirubin düzeyleri karboplatin grubundan anlamlı derecede düşüktü. Isırgan otu sabit yağı ile kontrol grubu arasında anlamlı farklılık saptanmadı. Vitamin C ve vitamin E uygulanan gruplarda belirlenen biyokimyasal değerler ise ısırgan otu sabit yağına benzer şekilde bulundu. Isırgan otu sabit yağı uygulamasının karboplatine bağlı karaciğer toksisitesini vitamin C ve E'ye eşit sayılabilecek derecede önleyebileceği sonucuna varıldı.

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Cite This Article

ÖZBEK, H., KÖSEM, M., ERDOĞAN, E., CENGİZ, N., ÖZGÖKÇE, F., SEVER, B. (2004). Are fixed oils of Urtica pilulifera L. protective against carboplatin-induced hepatotoxicity. Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences, Cilt: 20 - Sayı: 2, 53–58. https://ajindex.com/articles/333506

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