AI Summary & Key Takeaways
AI InsightConclusion: Evaluating the results of the duration, depth of surgical anesthesia and the physiologic parameters the xylazine-tiletamine-zolazepam combination shows that the combination can be recommended as a suitable anesthesic procedure for rabbits in experimental research.
📌 3 Key Takeaways
Abstract
Purpose: In this study, aimed at evaluation of xylazine-tiletamine-zolazepam and xylazine-ketamine anesthesia in rabbits. Materials and Methods: Two study groups included five New Zealand white rabbits in each group, three months of age, 1400-2050gr. weight. Ten minutes after atropine (0.5 mg/kg, im) premedication, anesthesia was induced with xylazjne (5 mg/kg, im) by both groups and maintained with tiletamine-zolazepam (15 mg/kg, im) in the first and ketamine (50 mg/kg, im) in the second group. Intermittent arterial blood samples were taken from the right femoral arteria at predetermined intervals (0, 20, 30, 40. minutes) before and after the anesthesia, these were tested for pH, $PaCO_2$: $PaO_2$, $SaO_2$. Data on reflexes, pain and physiologic parameters (heart rate, respiration rate, body temperature) were recorded at the above mentioned intervals. The duration of anesthesia, maintaining sternal recumbency and standing position were also recorded. The data were evaluated with nonparametric (Freidman and Mann-Whitney U) tests. Results: The mean anesthesia time, sternal recumbency time, standing time were recorded to be 36:20±2:55min, 64:80±7:68min, 104:60±4:02min in Ist. group and 27:60±3:50min; 43:00±5:83min, 75:40±7:97min in IInd. group respectively. Statisticaly the $PaO_2$ (p<0.001) and the $PaCO_2$ (p<0.05) alteration in firsth group as well as the SaO2 findings (p<0.05) in second group are considered to be important. Although there is no difference in heart rates between either groups (p>0.05), the respiration rates in both groups are irregular, whereas the in IInd. group (p<0.05) the respiration rate was shown significant differences. Conclusion: Evaluating the results of the duration, depth of surgical anesthesia and the physiologic parameters the xylazine-tiletamine-zolazepam combination shows that the combination can be recommended as a suitable anesthesic procedure for rabbits in experimental research.
Özet
Amaç: Bu deneysel çalışmada, tavşanlarda xylazine-tiletamine-zolazepam (Zoletil 50, Virbac) ve xylazine-ketamine genel anestezilerinin karşılaştırılması amaçlandı. Materyal ve Metot: Çalışma materyalini, ağırlıkları 1400-2050 gr. arasında değişen, üç aylık, on adet Yeni Zelanda tavşanı oluşturdu. Hayvanlarda, atropin (0.5 mg/kg, im) premedikasyonundan 10 dk sonra I. gruba (beş tavşan) xylazine (5mg/kg, im), tiletamine-zolazepam (15 mg/kg, im); II. gruba (beş tavşan) ise, xylazine (5mg/kg, im), ketamine (50mg/kg, im) uygulandı. Anes-tezi öncesi ve anestezi sonrası (0,20,30,40. dakikalarda) sağ a.femoralis'ten kan alınarak pH, $PaCO_2$, $PaO_2$, $SaO_2$, ayrıca bu aralıklarla kalp atım sayısı, solunum sayısı, vücut ısısı, ağrı bulguları, refleksler ve anestezi; göğüs üzerine yatabilme; tamamen ayakta durabilme süreleri yönünden elde edilen bulgular nonparametrik (Friedman ve Mann-Whitney U) testlerle değerlendirildi. Bulgular: Ortalama anestezi süresi L grupta 36:20±2:55 dk, II. grupta 27:60±3:50 dk; göğüs üzerine yatabilmesüresi I. grupta 64:80±7:68 dk, II. grupta 43:00±5:83 dk; ayakta durabilme süresi I. grupta 104:60±4.02 dk, II. grupta 75:40±7.97 dk olarak belirlendi. Birinci grupta PaO2 değerindeki değişim (p 0.05), solunum sayı-larının her iki grupta düzensiz seyrettiği ve II. grupta (p<0.05) farklar gösterdiği gözlendi. Sonuç: Tavşanlarda Xylazine-tiletamine-zolazepam ve xylazine-ketamine anestezileri değerlendirildiğinde, anestezi süresi, derinliği ve fizyolojik parametreler yönünden xylazine-tiletamine-zolazepam anestezisinin tercih edilebilir bir anestezi yöntemi olduğu belirlendi.