Journals / Veteriner Cerrahi Dergisi / 2005 / Cilt: 11 - Sayı: 1

Comparison of the effects of isoflurane and sevoflurane anesthesia on hemodynamic and biochemical parameters in dogs

Köpeklerde isoflurane ve sevoflurane anestezisinin hemodinamik ve biyokimyasal parametrelere olan etkilerinin karşılaştırılması

Pages
31–35
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the study, it is concluded that Isoflurane and Sevorane anaesthesia revealed similar results-and both anaestetics were appeared to have minimum complications.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:A total of 20 mongrel dogs were used in the study divided into two groups of 10 as, isoflurane and sevoflurane groups with mean body weights as 23.6±4 kg and 24±3 kg respectively. 04 mg/kg atropin sulphade was administered subcutanously 30 min before the study.
📊
Key Findings & Data:Dogs were sedated by 2mg/kg im administration of xylazine hydrochloride.
💡
Conclusion & Impact:In the study, it is concluded that Isoflurane and Sevorane anaesthesia revealed similar results-and both anaestetics were appeared to have minimum complications.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:kan şekeri · anestezi · kreatin

Abstract

A total of 20 mongrel dogs were used in the study divided into two groups of 10 as, isoflurane and sevoflurane groups with mean body weights as 23.6±4 kg and 24±3 kg respectively. 04 mg/kg atropin sulphade was administered subcutanously 30 min before the study. Dogs were sedated by 2mg/kg im administration of xylazine hydrochloride. Anaesthesia induced by iv administration of 15 mg/kg thiopentone sodium and 5 mcg/kg fentanyl citrate. An arterial catheter was inserted into the femoral artery and connected to the transducer for arterial blood pressure monitorization. Swan-Ganz termodilution catheter was placed inthorough the femoral vein. Electrodes were connected to the extremities for continuing ECG monitorization. First measuraments were recorded in both groups after haemodynamic stability achieved. Anaesthesia continued by 1.5 MAC isoflurane in isoflurane group, whereas 1.5 MAC sevoflurane was used in sevoflurane group. Heart rate, arterial blood pressure, CVP, RVP, PAP, PCWP, CO, pH, $PO_2, PCO_2, HCO_3, BE, O_2$ SAT % measuraments were made in both groups at 0., 30., 60. and 120. minutes. Serum samples were obtained from arterial blood taken at 0., 60., 120. min and ALT, AST, CK, Gucose, Creatine, Urea, Na, K and Cl levels were measured. Heart rate and PAP, levels at 0 and 60 min., PO2 levels at 0 min, Serum ALT levels at 60 and 120 min. were detected to be statistically different between the two groups(P<0.05). No statistical differences were found in other parameters (P>0.05). In the study, it is concluded that Isoflurane and Sevorane anaesthesia revealed similar results-and both anaestetics were appeared to have minimum complications.

Özet

Araştırmada, ağırlıkları ortalaması 23,6±4 kg olan 10 adet köpek isoflurane grubunda, 24,8±3 kg olan 10 adet köpek sevoflurane grubunda olmak üzere toplam 20 adet sokak köpeği kullanıldı. Çalışmadan 30 dk önce köpeklere subkutan yolla 0,04 mg/kg dozda Atropin sülfat uygulandı. On beş dakika sonra 2 mg/kg dozda Xylazine hydrochlorid im yolla uygulanarak sedasyon sağlandı. Her iki grupta indüksiyon 15 mg/kg Thiopenthal sodium ve Fentanyl Citrate 5. mcg/kg iv uygulamasıyla gerçekleştirildi. A.femoralis'e arter, kateteri ilerletilerek arteriyel kan basıncı monitörizasyonu Çin tıansduser bağlantısı gerçekleştirildi. V.femoralis'e Swan-Ganz teımodılusyon kateteri ilerletildi. Olguların ekstremi tel en ne tuttuıulan EKG elektrodlan aracılığıyla Çok kanallı monitörde sürekli EKG izlendi. Her ikigrupta hemodinamik stabilizasyon sağlandıktan sonra ilk ölçümler kaydedildi ve isoflurane grubunda 1,5 MAC isoflurane ile anestezi idamesi gerçekleştirilirken, sevoflurane grubunda yine 1,5 MAC sevoflurane ile anestezi idamesi gerçekleştirildi. Gruplarda 0, 30, 60, 120. dakikalarda; Nabız, Arteriyel kan basıncı, CVP, RVP, PAP, PCWP, CO ile $pH, PO_2, PCO_2, HCO_3, BE, % O_2$ SAT ölçümleri gerçekleştirildi. Her iki grupta da 0, 60, 120. dakikalarda alman arteriyel kan örneklerinden çıkarılan serumlardan ALT, AST, CK, Glikoz, Kreatinin, Üre, Na, K ve Cl düzeyleri ölçüldü. İki grubun 0 ve 60.dk nabız, 0 ve 60.dk PAP, 0 dk. PO2, 60 ve 120 dk serum ALT değerleri arasında istatistiksel fark saptandı (P 0.05). Araştırmada isoflurane anestezisinin sevoflurane anestezisi ile benzer sonuçlar verdiği, her iki anestezik ilacın da minimum komplikasyon sağladığı sonucuna ulaşıldı

🔖

Cite This Article

APAYDIN, N., KOÇ, B. (2005). Comparison of the effects of isoflurane and sevoflurane anesthesia on hemodynamic and biochemical parameters in dogs. Veteriner Cerrahi Dergisi, Cilt: 11 - Sayı: 1, 31–35. https://ajindex.com/articles/333080

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Bernard J.M., Doursout M.F., Wouters P., Hartley C.J., Merin R.G., Chelly J.E. (1992): Effects of sevoflurane and isoflurane on hepatic circulation in the chronically instrumented dogs. Anesthesiology. 77: 541-545
  2. Branson K.R., Quandt J.E., Martinez E.A., Trim C.M., Dodam J.R., Hartsfield S.M., Matthews N.S., Mackenthum A., Beleau M.H. (2001): A multisite case report on the clinical use of sevoflurane in dogs. J. Am. Amin. Hosp. Assoc. 37: 420-432
  3. Cantalapiedra A.G.,Laredo F., Villanueva B., Pereira J.L. (2000): Comparison between isoflurane and sevoflurane anaesthesia in dogs. Vet. Anesth. Analg. 27: 54-62
  4. Düzgün O., Perk E.C. (1998): Köpeklerde ketamin indüksiyonu ile gerçeklestirilen isofloran anestezisi ve kan tablosuna etkileri üzerine arastırmalar. stanbul Üni. Vet. Fak. Der. 24:379-401 5. Gwinnutt C.L. (1996): Clinical Anaesthesia “Maintenance of anaesthesia: Inhalational (Volatile) Agents and Intravenous Infusions” Oxford. capter 5. p.: 92-97
  5. Hall L.W., Clarke K.W. (1991): Veterinary Anaesthesia “General Pharmacology of the Inhalation Anaestheties” London. capter 6. p.: 108
  6. Haskins S.C. (1996): Monitoring The Anaesthetized Patients. Chapter 15: Lumb and Jones’ Veterinary Anesthesia. Third Ed. Ed: Thurmon Williams and Wilkins Co. U.S.A. p.: 409-424
  7. Hayat A. (2001): Köpeklerde halotan ve sevofluranın bazı klinik, hematolojik, biyokimyasal degerler ile kardiyovasküler sistem üzerine etkilerinin karsılastırılması. F. Ü. Sağ. Bil. Doktora Tezi
  8. Johnson R.A., Striler E., Sawter D.C., Brunsond B. (1998): Comparasion of isoflurane with sevoflurane for anesthesia induction and recoveryin adult dogs. Am. J. Vet. Res. 59:478-481
  9. Katoh T., Ikeda K. (1994): A comparison of sevoflurane with halotane, enflurane and isoflurane on bronchoconstriction caused by histamine. Can. J. Anaesth. 41: 1214-1219
  10. Ko J.C.H., Lange D.N., Mandsager R.E., Payton M.E., Bowen C., Kamata A., Kuo W. (2000): Effect of butorphanol and carprofen on the minimal alveolar concentration of isoflurane in dogs. JAVMA. 217:1025-1028
  11. Koç B. (1996): Veteriner Anesteziyoloji ve Reanimasyon. Ögr. Ders Notları, AÜ. Vet. Fak. Ankara
  12. Lee D.D., Meyer R.E., Sullivan T.C., Davidson M.G., Swanson C.R., Hellyer P.W. (1998): Respiratory depressant and skeletal muscle relaxant effects of lowdose pancuronium bromide in spontaneusly breayhing, isoflurane-anesthetized dogs. Vet. Surg. 27: 473-479
  13. Mutoh T., Nishimura R., Kim H., Matsunaga S., Sasaki N. (1997