Journals / Türk Yoğun Bakım Dergisi / 2013 / Cilt: 11 - Sayı: 2

Akut zehirlenme nedeniyle mekanik ventilasyon uygulanan hastaların karakteristik özellikleri ve sonuçları

Characteristics and outcomes of adult patients receiving mechanical ventilation due to acute poisoning

Pages
54–59
DOI
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The need of MV may lead to poor outcome as it is associated with higher incidence of ventilator related complications and longer ICU stay.

📌 3 Key Takeaways

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Objective & Hypothesis:SUMMARY Objective: Poisoning is an important cause of admission to intensive care units (ICUs) and prolongs the length of stay (LOS) in the ICU.
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Key Findings & Data:The need of prolonged MV causes a significantly longer LOS and higher mortality in the ICU.
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Conclusion & Impact:The need of MV may lead to poor outcome as it is associated with higher incidence of ventilator related complications and longer ICU stay.
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Abstract

SUMMARY Objective: Poisoning is an important cause of admission to intensive care units (ICUs) and prolongs the length of stay (LOS) in the ICU. The patients whose admitted to the ICU with poisoning may require mechanical ventilation (MV). The need of prolonged MV causes a significantly longer LOS and higher mortality in the ICU. The analysis of the characteristics and outcomes of patients receiving MV after poisoning may be useful in the clinical management of these patients, allowing for better counseling of the patients and their families. The objective of this retrospective study to evaluate the relationship between demographic and etiological characteristics with need of MV in patients admitted to ICU due to poisoning. Material and Method: 211 patients diagnosed with poisoning were analyzed from January 2010 to December 2011. Data regarding age, gender, the time between exposure and ICU admission, type of poisoning, exposure to toxic agents, the route of exposure, a history of previous toxicity, consciousness status on arrival, the length of the ICU stay, need of MV, complications associated with MV, the Glasgow coma scale and outcome were obtained. Results: Of the 211 patients, 143 (67.8%) were female. The most common cause of poisoning was suicide (87.7%), and the main route of exposure was oral (93.4%). The greatest number of agents which patients were exposed was drugs. (74.4%). The most common drugs causing poisoning were antidepressants (including tricyclic antidepressants) (38.3%). The need of MV was significantly related to both gender (p=0.04) and the route of exposure (p<0.001). The need of MV was also significantly related to type of poisoning (p=0.01) and the toxic agents (p<0.001).There were very strong relationships between the drug poisoning and gender (p=0.002) and between type of poisoning and gender (p=0.006). Conclusion: The present study demonstrated that there were significant relationships between the need of MV and gender, type of poisoning, the toxic agents, the route of exposure and the ICU LOS. The need of MV may lead to poor outcome as it is associated with higher incidence of ventilator related complications and longer ICU stay.

Özet

ÖZET Amaç: Zehirlenme, yoğun bakım ünitelerine (YBÜ) kabulün önemli bir nedenidir ve yoğun bakımda kalış süresini uzatır. Zehirlenme nedeniyle YBܒye kabul edilen hastalar mekanik ventilasyona (MV) ihtiyaç duyabilirler. Uzamış MV gereksinimi YBܒde kalış süresini ve mortaliteyi artırır. Zehirlenme nedeniyle MV uygulanan hastaların özellikleri ve sonuçlarının değerlendirilmesi, klinik yönetimde yararlı olabilir ve hastalar ile ailelerine daha iyi danışmanlık sağlayabilir. Bu geriye dönük çalışmanın amacı zehirlenme nedeniyle YBܒye yatırılan hastaların demografik ve etiyolojik özellikleri ile MV ihtiyacı arasındaki ilişkiyi incelemektir. Gereç ve Yöntem: Ocak 2010 - Aralık 2011 tarihleri arasında YBܒye kabul edilen 211 değerlendirildi. Yaş, cinsiyet, zehirlenme oluşumu ile YBܒye kabulüne kadar geçen süre, zehirlenmenin tipi, maruz kalınan toksik ajanlar, alınma yolu, daha önceki zehirlenme öyküsü, başvurudaki bilinç durumu, YBܒde kalış süresi, MV ihtiyacı. MV ile ilişkili komplikasyonlar, Glasgow koma skoru ve sonuçları incelendi. Bulgular: Değerlendirilen 211 hastanın 143’ü (%67,8) kadındı. Zehirlenmenin en sık nedeni intihar (%87,7) idi ve oral yol ile (%93,4) gerçekleşmişti. Hastaların en çok maruz kaldığı ajanlar ilaçlardı (%74,4). İlaçlarla oluşan zehirlenmenin en sık nedeni antidepresanlar (trisiklik antidepresanlar dahil) (%38,3) idi. MV ihtiyacı hem cinsiyet (p=0,04), hem de alınma yolu ile anlamlı şekilde ilişkiliydi. MV ihtiyacı zehirlenmenin tipi (p=0,01) ve toksik ajanlar (p<0,001) ile de anlamlı şekilde ilişkiliydi. İlaçlarla zehirlenme ile cinsiyet (p=0,002) ve zehirlenme tipi ile cinsiyet (p=0,006) arasında oldukça güçlü bir ilişki vardı. Sonuç: Bu çalışmada MV ihtiyacı ile cinsiyet, zehirlenmenin tipi, toksik ajanlar, alınma yolu ve YBܒde kalış süresi arasında anlamlı bir ilişki olduğu gösterildi. MV ihtiyacı ventilatöre bağlı komplikasyonların sıklığı ve daha uzun süre YBܒde yatışı ile ilişkili olarak kötü prognoza öncülük edebilir.

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Cite This Article

ERDOĞAN, M. A., AYDOĞAN, M. S., ÖZGÜL, Ü., GEDİK, E., TOĞAL, T., DURMUŞ, M., ÇOLAK, C., UÇAR, M. (2013). Akut zehirlenme nedeniyle mekanik ventilasyon uygulanan hastaların karakteristik özellikleri ve sonuçları. Türk Yoğun Bakım Dergisi, Cilt: 11 - Sayı: 2, 54–59. https://ajindex.com/articles/327806

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