Journals / Türk Yoğun Bakım Dergisi / 2016 / Cilt: 14 - Sayı: 3

Cerebral Salt Wasting Syndrome

Serebral Tuz Kaybı Sendromu

Pages
105–109
DOI
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⚡ TL;DR(Too Long; Didn't Read)

In this article, it was aimed to report a patient with CSWS which progresses with low percentage in intensive care unit patients with head trauma, is frequently confused with inappropriate antidiuretic hormone syndrome and progresses mortally when not diagnosed distinctively well.

📌 3 Key Takeaways

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Objective & Hypothesis:A serum sodium (Na) value below 135 mEq/L is evaluated as hyponatremia.
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Key Findings & Data:CSWS is a rare condition progressing with low plasma osmolality, urine osmolality above 100-150 mOsm/kg and urineNa concentration above 20 mEq/L.
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Conclusion & Impact:In this article, it was aimed to report a patient with CSWS which progresses with low percentage in intensive care unit patients with head trauma, is frequently confused with inappropriate antidiuretic hormone syndrome and progresses mortally when not diagnosed distinctively well.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

A serum sodium (Na) value below 135 mEq/L is evaluated as hyponatremia. Hyponatremia is the most common electrolyte abnormality observed in hospitalized patients in particular. Hypovolemic hypoosmolar hyponatremia is the most frequent clinical table. One of the reasons of this is cerebral salt-wasting syndrome (CSWS). CSWS is a rare condition progressing with low plasma osmolality, urine osmolality above 100-150 mOsm/kg and urineNa concentration above 20 mEq/L. In the blood and urine sample analysis performed upon sudden loss of consciousness on the 15th day of the intensive care unit follow-up of 79-year-old female patients due to falling from stairs, blood biochemistry Na value was 120 mEq/L, plasma osmolality was 250 mOsm/kg, urine Na value was 180 mEq/L, urine osmolality was 1200 mOsm/kg, urine diuresis was >3 mL/kg/hour. The central venous pressure was 2 mmHg. The patient, considered to be diagnosed with CSWS, was treated with 9% NaCl and 3% hypertonic saline solution. Her clinical course was improved on the 18th day. She died on the 81st day secondary to septicemia in the subsequent follow-up. In this article, it was aimed to report a patient with CSWS which progresses with low percentage in intensive care unit patients with head trauma, is frequently confused with inappropriate antidiuretic hormone syndrome and progresses mortally when not diagnosed distinctively well.

Özet

Serum sodyum (Na) değerinin 135 mEq/L'nin altında bulunması hiponatremi olarak değerlendirilir. Hiponatremi en sık karşılaşılan ve özellikle hastanede yatan hastalarda görülen elektrolit bozukluğudur. Hipovolemik hipoosmolar hiponatremi en sık gözlenen klinik tablodur. Bunun nedenlerinden biri de serebral tuz kaybı sendromudur (STKS). STKS düşük plazma osmolalitesi, 100-150 mOsm/kg'ın üzerinde idrar osmolalitesi ve 20 mEq/L üzerinde idrar Na konsantrasyonu ile seyreden nadir bir durumdur. Merdivenden düşme nedeniyle 79 yaşındaki kadın hastanın yoğun bakımdaki takibinin 16. günü ani bilinç kaybı gelişmesi üzerine yapılan kan ve idrar örnek analizinde kan biyokimya Na değeri 120 mEq/L, plazma osmolalitesi 250 mOsm/kg, idrar Na değeri 180 mEq/L, idrar osmolalitesi 1200 mOsm/kg, idrar diürezi >3 mL/kg/saat olarak tespit edildi. Santral venöz basınç 2 mmHg ölçüldü. Serebral tuz kaybı sendromu düşünülen hasta %9 NaCl ve %3'lük hipertonik salin solüsyonu ile tedavi edildi. Tablosu 18. günde düzeldi. Sonraki takibinde septisemiye sekonder 81. günde eks oldu. Bu yazıda kafa travmasına maruz kalmış yoğun bakım hastalarında düşük yüzde ile seyreden ve sıklıkla uygunsuz antidiüretik hormon sendromu ile karışan ve ayırıcı tanısı iyi yapılmadığı takdirde mortal seyreden STKS'li bir olgu sunumu amaçlandı.

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Cite This Article

SEVDİ, M. S., ERKALP, K., AKAGÜNDÜZ, E. S., FIRINCIOĞLU, A., SELCAN, A. (2016). Cerebral Salt Wasting Syndrome. Türk Yoğun Bakım Dergisi, Cilt: 14 - Sayı: 3, 105–109. https://ajindex.com/articles/327756

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