Journals / Türk Yoğun Bakım Dergisi / 2019 / Cilt: 17 - Sayı: 2

Thrombolytic Use During Cardiopulmonary Arrest in Massive Pulmonary Embolism: Return to Life of Two Patients

Kardiyopulmoner Arrest Gelişen Masif Pulmoner Embolide Trombolitik Kullanımı: Hayata Dönen İki Hasta

Pages
102–106
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This procedure will treat the condition caused by arrest and also is shown to have beneficial effects on the early microcirculatory cerebral reperfusion and to prevent neurological sequelae.

📌 3 Key Takeaways

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Objective & Hypothesis:The diagnosis of pulmonary embolism is still difficult, because it may occur with different symptoms and signs.
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Key Findings & Data:More than 70 percent of cardiopulmonary arrest cases are caused by acute myocardial infarction or massive pulmonary embolism and it has a poor prognosis.
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Conclusion & Impact:This procedure will treat the condition caused by arrest and also is shown to have beneficial effects on the early microcirculatory cerebral reperfusion and to prevent neurological sequelae.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The diagnosis of pulmonary embolism is still difficult, because it may occur with different symptoms and signs. These cases can be admitted to the emergency department with shock, syncope or cardiopulmonary arrest. More than 70 percent of cardiopulmonary arrest cases are caused by acute myocardial infarction or massive pulmonary embolism and it has a poor prognosis. We present two cases of massive pulmonary embolism requiring cardiopulmonary resuscitation and administered thrombolytic agents. Two patients received 10 mg bolus of recombinant tissue-type plasminogen activator (alteplase) followed by 90 mg intravenous infusion for two hours. Rapid clinical and hemodynamic improvement occurred after thrombolytic injection and the patients were discharged from the hospital. In case of suspicion of massive pulmonary embolism in cardiopulmonary arrest cases, thrombolytic agents should be administered during cardiopulmonary resuscitation. This procedure will treat the condition caused by arrest and also is shown to have beneficial effects on the early microcirculatory cerebral reperfusion and to prevent neurological sequelae.

Özet

Pulmoner emboli teşhisi halen zordur, çünkü farklı semptom ve bulgular ile seyredebilmektedir. Bu olgular acil servislere şok, senkop veya kardiyopulmoner arrest ile gelebilmektedir. Kardiyopulmoner arrestlerin %70’inden fazlası akut miyokard infarktüsü veya masif pulmoner emboli nedeniyle ortaya çıkmaktadır ve prognoz kötüdür. Bu yazıda kardiyopulmoner resüsitasyon (CPR) gerektiren ve trombolitik ajan uygulanan masif pulmoner embolili iki hasta sunulmuştur. Hastalara 10 mg bolus şeklinde rekombinant doku tip plazminojen aktivatörü (alteplaz) uygulanmış ve ardından iki saat boyunca 90 mg intravenöz infüzyona devam edilmiştir. Trombolitik verilmesi sonrasında hızlı klinik ve hemodinamik iyileşme tespit edilmiş ve hastalar düzelme sonrasında hastaneden taburcu edilmiştir. Kardiyopulmoner arrest gelişen hastalarda eğer altta yatan hastalığın masif pulmoner emboli olduğundan şüpheleniliyor ise, CPR ile birlikte trombolitik ajanlar da uygulanmalıdır. Bu prosedür, arrestin neden olduğu durumu tedavi edecek ve erken mikrodolaşım, serebral perfüzyonu iyi yönde etkileyecek ve nörolojik sekel oluşumunu engelleyecektir.

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Cite This Article

ALİZOROĞLU, D., ERBAYCU, A. E., ÇİMEN, P., EDİBOĞLU, Ö., KIRAKLI, S. C. (2019). Thrombolytic Use During Cardiopulmonary Arrest in Massive Pulmonary Embolism: Return to Life of Two Patients. Türk Yoğun Bakım Dergisi, Cilt: 17 - Sayı: 2, 102–106. https://ajindex.com/articles/327717

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