Journals / Journal of the Turkish-German Gynecological Association / 2012 / Cilt: 13 - Sayı: 1

Servikal patolojisi olan ve olmayan olgularda HPV DNA ve Pap smear test sonuçları

HPV DNA and Pap smear test results in cases with and without cervical pathology

Pages
8–14
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

In positive HPV cases there is a good correlation between HPV type and positive cervical biopsy results. (J Turkish-German Gynecol Assoc 2012; 13: 8-14)

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of the study was to determine the HPV prevalance and its relation to Pap smear, colposcopy and colposcopy directed biopsy in our region of Eskisehir, Turkey.
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Key Findings & Data:Material and Methods: A total of 615 women who applied to the outpatient clinic between December 2009 and December 2010 constituted our study population.
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Conclusion & Impact:In positive HPV cases there is a good correlation between HPV type and positive cervical biopsy results. (J Turkish-German Gynecol Assoc 2012; 13: 8-14)
🔬Design:Research Article
📍Scope:2009 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of the study was to determine the HPV prevalance and its relation to Pap smear, colposcopy and colposcopy directed biopsy in our region of Eskisehir, Turkey. Material and Methods: A total of 615 women who applied to the outpatient clinic between December 2009 and December 2010 constituted our study population. All patients underwent pelvic examination and Pap smear sampling. Patients who had pathological cervical appearance or Pap smear results of ASCUS, AGUS, LSIL or HSIL were referred to colposcopy. Cervical samples for HPV DNA were taken from the patients before Pap smear sampling during the routine examination or before the colposcopic evaluation. Results: Twenty six of 615 patients (4%) were HPV positive. Of these 26 patients, 12 were positive for HPV type 16, 3 for type 18, 3 for type 51, 2 for type 6, 1 for type 52, 1 for type 33, 1 for type 16 and type 31, 1 for type 6 and 52, 1 for type 56 and 90, 1 for type 39 and 66. In 4 patients with cervical cancer, and in 3 of 4 CIN III cases both HPV DNA and Pap smear were positive. In the Pap smear examination of 615 patients, cytology revealed 35 ASCUS (5.6%) 4 AGUS (0.6%), 2 CIN I (0.3%) results who were negative for HPV DNA. These patients with abnormal cytology (n=41) underwent colposcopy directed biopsy, there were 3 CIN I and 1 CIN III and all the other cervical biopsy results of these patients were benign (inflammation, chronic cervicitis). Conclusion: HPV positivity in our hospital setting is low which is compatible with other studies in Turkey. In positive HPV cases there is a good correlation between HPV type and positive cervical biopsy results. (J Turkish-German Gynecol Assoc 2012; 13: 8-14)

Özet

Amaç: Çalışmanın amacı Türkiye’nin Eskişehir bölgesinde HPV prevalansı ve bunun Pap smear, kolposkopi ve kolposkopik biopsi ile ilişkisini belirlemektir. Gereç ve Yöntemler: Aralık 2009 ile Aralık 2010 tarihleri arasında polikliniğimize başvuran 615 hasta çalışma grubumuzu oluşturdu. Bütün hastalara pelvik muayene yapılıp, hastaların hepsinden Pap smear alındı. Serviksinde patolojik görünüm olan hastalara veya Pap smear sonucu ASCUS, AGUS, LSIL veya HSIL olan hastalara kolposkopik inceleme yapıldı. Hastalardan ya rutin değerlendirme sırasında Pap smear alınmadan önce ya da kolposkopik muayene öncesinde HPV DNA için servikal örnek alındı. Bulgular: Altıyüzonbeş hastanın 26’sı (%4) HPV pozitifti. Bu 26 hastanın 12’sinde HPV tip 16, 3 tanesinde tip 18, 3 tanesinde tip 51, 2 tanesinde tip 6, 1 tanesinde tip 52, 1 tanesinde tip 33, 1 tanesinde tip 16 ve tip 31, 1 tanesinde tip 6 ve 52, 1 tanesinde tip 56 ve 90, 1 tanesinde tip 39 ve 66 mevcuttu. Serviks kanseri olan 4 hasta ve CIN III olan 4 hastanın 3’ünde hem HPV DNA hem de Pap smear pozitifti. Altıyüzonbeş hastanın Pap smear sonuçlarına bakıldığında HPV DNA negatif olan 35 ASCUS (%5.6), 4 AGUS (%0.6), 2 CIN I (%0.3) olan hasta vardı. Anormal sitolojisi olan bu 41 hastaya kolposkopik biopsi yapıldı ve sonuçta sadece 3 hastada CIN I, 1 hastada CIN III varken kalan hastaların biopsi sonuçları benigndi (inflamasyon, kronik servisit). Sonuç: Hastanemizde yapılan bu çalışmada elde edilen HPV oranları Türkiye’de yapılan diğer çalışmalarla uygun olarak düşük bulundu. HPV pozitif olan vakalarda HPV tipi ile pozitif servikal biopsi sonuçları arasında kuvvetli bir korelasyon mevcuttur. (J Turkish-German Gynecol Assoc 2012; 13: 8-14)

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Cite This Article

ARSLAN, E., KAŞİFOĞLU, N., ÖGE, T., ÖZALP, S. S., US, T. (2022). Servikal patolojisi olan ve olmayan olgularda HPV DNA ve Pap smear test sonuçları. Journal of the Turkish-German Gynecological Association, Cilt: 13 - Sayı: 1, 8–14. https://ajindex.com/articles/325981

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