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Journals / Ulusal Cerrahi Dergisi / 2009 / Cilt: 25 - Sayı: 4

N-acetylcysteine can attenuate liver injury in obstructive jaundice in rats

N-asetilsistein sıçanlarda tıkanma sarılığına bağlı karaciğer hasarını azaltabilir

H. Hakan MERSİN
Murat AKBABA
Emel BAŞKAN
ALİ UĞUR BERBEROĞLU
Pages
146–149
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: NAC can be useful in decreasing the paranchymal damage in the liver and suppress the plasma TNF-α levels in experimental obstructive jaundice.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: To investigate the effect of N-acetylcysteine (NAC) on the level of tumor necrosis factor-a (TNF-α) and liver parenchyma injury in an experimental rat model of obstructive jaundice.
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Key Findings & Data:Patients and Methods: Thirty-six Wistar-Albino rats weighing 250- 300 g were randomly divided into three groups of 12 animals in each, as sham-operated, bile duct ligated plus NAC-treated (treatment), bile duct ligated plus saline administered (control).
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Conclusion & Impact:Conclusion: NAC can be useful in decreasing the paranchymal damage in the liver and suppress the plasma TNF-α levels in experimental obstructive jaundice.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Asetilsistein · Modeller · hayvan

Abstract

Purpose: To investigate the effect of N-acetylcysteine (NAC) on the level of tumor necrosis factor-a (TNF-α) and liver parenchyma injury in an experimental rat model of obstructive jaundice. Patients and Methods: Thirty-six Wistar-Albino rats weighing 250- 300 g were randomly divided into three groups of 12 animals in each, as sham-operated, bile duct ligated plus NAC-treated (treatment), bile duct ligated plus saline administered (control). After the operation, the rats in treatment and control groups were administered NAC and saline, respectively. After 10 days of treatment, liver function tests were performed and plasma TNF-a levels were determined in all rats to assess the parenchymal damage. Results: Parenchymal damage and plasma TNF-α levels were significantly lower in the treatment group, compared with the control group. Conclusion: NAC can be useful in decreasing the paranchymal damage in the liver and suppress the plasma TNF-α levels in experimental obstructive jaundice.

Özet

Amaç: Tıkanma sarılıklı sıçanlarda N-Asetilsisteinin (NAS) plazma tümör nekrozis faktör alfa (TNF-α) düzeyleri üzerine ve karaciğer parenkim hasarına etkisini araştırmak. Gereç ve Yöntem: Ağırlıkları 250-300 g arasında değişen 36 adet Wistar-Albino cinsi sıçan sham operasyonu yapılan (sham grubu), koledok kanalı bağlanarak NAS tedavisi verilen (tedavi grubu) ve koledok kanalı bağlanan ama tedavi verilmeyen (kontrol grubu) olmak üzere 12'şerli üç gruba ayrıldı. Tedavi ve kontrol grubundaki sıçanlara ameliyat sonrası 10 gün süresince sırasıyla NAS veya serum fizyolojik uygulandı. On günlük tedaviyi takiben parenkim hasarını değerlendirmek için tüm sıçanların karaciğer fonksiyon testleri ve plazma TNF-a düzeyleri ölçüldü. Bulgular: Tedavi grubunda parenkim hasarının kontrol grubuna göre anlamlı olarak daha az olduğu ve plazma TNF-α düzeylerinin de anlamlı ölçüde düşük olduğu saptandı. Sonuç: NAS deneysel tıkanma sarılığında plazma TNF-α düzeylerinin baskılanması ve karaciğer parenkim hasarının azaltılmasında faydalı olabilir.

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Cite This Article

MERSİN, H. H., AKBABA, M., BAŞKAN, E., BERBEROĞLU, A. U. (2009). N-acetylcysteine can attenuate liver injury in obstructive jaundice in rats. Ulusal Cerrahi Dergisi, Cilt: 25 - Sayı: 4, 146–149. https://ajindex.com/articles/325511

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