Journals / Ulusal Travma Dergisi / 1999 / Cilt: 5 - Sayı: 3

The clinical and histopathological evaluation of effects of magnesium sulphate in experimental medulla spinalis trauma

Deneysel medulla spinalis travmasında magnezyum sülfatın klinik ve histopatolojik etkilerinin incelenmesi

Pages
147–151
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, usage of magnesium sulphate resultedim20% histopathologicaland26% clinicalimprovement of the neurological deterioration which develops as a result of weight drop technic trauma of medulla spinalis and consequent neuronal injury in the rabbits.

📌 3 Key Takeaways

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Objective & Hypothesis:It is known that secondary injury following spinal trauma develops as a result of a series of biochemical reactions.
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Key Findings & Data:Several phannachological agents have been used to break this reaction chain.
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Conclusion & Impact:In this study, usage of magnesium sulphate resultedim20% histopathologicaland26% clinicalimprovement of the neurological deterioration which develops as a result of weight drop technic trauma of medulla spinalis and consequent neuronal injury in the rabbits.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hastalık modelleri · hayvan · Yaralar ve yaralanmalar

Abstract

It is known that secondary injury following spinal trauma develops as a result of a series of biochemical reactions. Several phannachological agents have been used to break this reaction chain. Magnesium sulphate which acts as a N-methyl-D-aspartate receptor antagonist in the brain was used in this studyr At present magnesium sulphate is being used in the treatment of eclampsia andtetanus. In this study, usage of magnesium sulphate resultedim20% histopathologicaland26% clinicalimprovement of the neurological deterioration which develops as a result of weight drop technic trauma of medulla spinalis and consequent neuronal injury in the rabbits.

Özet

Spinal travmalarda sekonder hasarın bir dizi biyokimyasal reaksiyon sonucu oluştuğu bilinmektedir. Yapüan çeşitli çalış malarda bu reaksiyon zincirini durdurmaya yönelik birçok farmakolojik .ajan denenımştir. Bu çalışmada beyinde N-metil-D- aspartat reseptör antağonisti olarak etki yapan magnezyum sülfat kullanıldı. Magnezyum sülfat klinikte eklampsi ve tetanusda kullanılan bir ilaçtır. Tavşanlarda ağırlık düşürme yöntemiyle oluşturulan-medulla spinalis travmasından sonra oluşan nöronal doku hasarı ve bunun sonucu olarak gelişen nörolojik bozukluğundaınagnezyu'm sülfat ile histopatolojik %20, klinik %26 düzelme sağlanmıştır.

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Cite This Article

ŞENEL, A., YILDIZ, Ö., YILDIZ, L., ÇOKLUK, C., TÜMKAYA, L., İYİGÜN, Ö., ÖNDER, A., ÇELİK, F., RAKUNT, C. (1999). The clinical and histopathological evaluation of effects of magnesium sulphate in experimental medulla spinalis trauma. Ulusal Travma Dergisi, Cilt: 5 - Sayı: 3, 147–151. https://ajindex.com/articles/325066

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