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Journals / Ulusal Travma Dergisi / 2003 / Cilt: 9 - Sayı: 3

Hemorajik şokta oksijen serbest radikalleri üzerine hipertonik salin, HAES ve dimetilsülfoksit'in etkileri

Effects of hypertonic saline, HAES and dymethylsulphoxyde on free oxygen radicals in haemorrhagic shock

AYŞEGÜL BAYIR
M. Ertuğrul KAFALI
AHMET AK
Mustafa ŞAHİN
Emrah KARAGÖZOĞLU
Mehmet GÜL
Kaan KARABULUT
Pages
154–159
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Resuscitation fluids and addition of antioxidants to the resuscitation fluids do not have any superiorities over each other to prevent tissue ischemic insult in haemorrhagic shock.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: The aim of this study was to investigate the effects of antioxidant and resuscitation fluids which were used during haemorrhagic shock on tissue ischemia.
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Key Findings & Data:Thirty minutes after shock, Group C was not resuscitated while Group I was resuscitated with Hypertonic saline 7.2, Group H with 10 % HAES and Group D with HAES 10 % and DMSO.
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Conclusion & Impact:Conclusion: Resuscitation fluids and addition of antioxidants to the resuscitation fluids do not have any superiorities over each other to prevent tissue ischemic insult in haemorrhagic shock.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Dimetil sülfoksit · Eritrositler · Modeller

Abstract

Background: The aim of this study was to investigate the effects of antioxidant and resuscitation fluids which were used during haemorrhagic shock on tissue ischemia. Methods: Forty New Zealand type rabbits were divided into four groups as C (control), I (hypertonic saline), H (HAES) and D (Dymethylsulphdxide-DMSO). Haemorrhagic shock was induced by bleeding from carotid artery. Thirty minutes after shock, Group C was not resuscitated while Group I was resuscitated with Hypertonic saline 7.2, Group H with 10 % HAES and Group D with HAES 10 % and DMSO. Thiobarbituric acid reactive substances (TBARS) and lactate levels in blood, liver and small bowel samples were measured. Results: There were no significant differences among the groups tissue and plasma TBARS and lactate levels. Conclusion: Resuscitation fluids and addition of antioxidants to the resuscitation fluids do not have any superiorities over each other to prevent tissue ischemic insult in haemorrhagic shock.

Özet

Amaç: Bu çalışmada amaç hemorajik flok sırasında kullanılan resusitasyon sıvılarının ve bunlara antioksidan eklenmesinin doku iskemisi üzerine etkilerini araştırmaktır. Gereç ve yöntem: Kırk adet Yeni Zelanda tipi tavşan K (kontrol), I (hipertonik salin), H (HAES) ve D (dimetilsulfoksit-DMSO) olarak dört gruba ayrıldılar. Tavşanlar karotid arter yolu ile kanatıldılar. Otuz dk. floktan sonra K grubuna sıvı resusitasyonu yapılmazken, I grubuna kanama miktarının 1.5 katı olacak şekilde %7.2’lik hipertonik salin, H grubuna kanama volümüne eşit volümde HAES %10 verildi. D grubuna ise HAES %10 ile birlikte antioksidan olarak DMSO eklendi. Sıvıların ve DMSO’nun etkisini değerlendirmek için kan, karaciğer ve ince barsak TBARS (thiobarbütürik asit reaktif maddeleri) ve laktat düzeyleri çalışıldı. Bulgular: Grupların doku ve plazma TBARS ve laktat seviyeleri birbiri ile karşılaştırılınca istatistiksel olarak anlamlı bir fark olmadığı görüldü. Sonuç: Replasman sıvılarının ve bunlara antioksidan ajan eklemenin hemorajik şokta gelişen dou iskemisini azaltmada birbirlerine üstünlüğü yoktur.

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Cite This Article

BAYIR, A., KAFALI, M. E., AK, A., ŞAHİN, M., KARAGÖZOĞLU, E., GÜL, M., KARABULUT, K. (2003). Hemorajik şokta oksijen serbest radikalleri üzerine hipertonik salin, HAES ve dimetilsülfoksit'in etkileri. Ulusal Travma Dergisi, Cilt: 9 - Sayı: 3, 154–159. https://ajindex.com/articles/325000

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