SavedAdd your journal

Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2017 / Cilt: 23 - Sayı: 3

Anti-edematous, anti-inflammatory and neuroprotective effect of etanercept in acute stage in experimental head injury

Ömer AYKANAT
Durmuş Oğuz KARAKOYUN
MEHMET ERHAN TÜRKOĞLU
CEM DİNÇ
Pages
173–180
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Moreover, a significant difference was observed between groups of Trauma + NS and trauma+etanercept and between the groups of trauma + dexamethasone and trauma + etanercept in terms of all variables.CONCLUSION: It was observed that etanercept has anti-edematous, anti-inflammatory, and neuroprotective effect on the rats which experienced traumatic brain injury

📌 3 Key Takeaways

🎯
Objective & Hypothesis:BACKGROUND: To study the anti-edematous, anti-inflammatory, and neuroprotective effect of etanercept in the model of experimental head injury.METHODS: In this study, 40 male-adult Spraque-Dawley rats, with weight ranging from 250g to 300g, were used.
📊
Key Findings & Data:After applying trauma and medicine, rats were decapitated in the 24thhour and the samples were studied histopathologically.RESULTS: In the study, a statistically significant difference was observed between the groups of trauma + NS and trauma dexamethasone according to the variables of edema and inflammation, but no difference was observed according to the variables of neuronal damage, astrocytic damage, and glial apoptosis.
💡
Conclusion & Impact:Moreover, a significant difference was observed between groups of Trauma + NS and trauma+etanercept and between the groups of trauma + dexamethasone and trauma + etanercept in terms of all variables.CONCLUSION: It was observed that etanercept has anti-edematous, anti-inflammatory, and neuroprotective effect on the rats which experienced traumatic brain injury
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

BACKGROUND: To study the anti-edematous, anti-inflammatory, and neuroprotective effect of etanercept in the model of experimental head injury.METHODS: In this study, 40 male-adult Spraque-Dawley rats, with weight ranging from 250g to 300g, were used. The rats are divided into groups as control; non-penetrating trauma; trauma +NS; post-traumatic normal saline; trauma + D; post-traumatic dexamethasone and trauma + E. All medicines were given into peritoneum. After applying trauma and medicine, rats were decapitated in the 24thhour and the samples were studied histopathologically.RESULTS: In the study, a statistically significant difference was observed between the groups of trauma + NS and trauma dexamethasone according to the variables of edema and inflammation, but no difference was observed according to the variables of neuronal damage, astrocytic damage, and glial apoptosis. Moreover, a significant difference was observed between groups of Trauma + NS and trauma+etanercept and between the groups of trauma + dexamethasone and trauma + etanercept in terms of all variables.CONCLUSION: It was observed that etanercept has anti-edematous, anti-inflammatory, and neuroprotective effect on the rats which experienced traumatic brain injury

🔖

Cite This Article

AYKANAT, Ö., KARAKOYUN, D. O., TÜRKOĞLU, M. E., DİNÇ, C. (2017). Anti-edematous, anti-inflammatory and neuroprotective effect of etanercept in acute stage in experimental head injury. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 23 - Sayı: 3, 173–180. https://ajindex.com/articles/324495

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Maas AI, Stocchetti N, Bullock R. Moderate and severe traumatic brain injury in adults. Lancet Neurol 2008;7:728–41
  2. Greenberg MS: Handbook of Neurosurgery. Thieme New York 2001:677–79
  3. Lloyd DA, Carty H, Patterson M, Butcher CK, Roe D. Predictive value of skull radiography for intracranial injury in children with blunt head injury. Lancet 1997;349:821–4
  4. Meyer P, Legros C, Orliaguet G. Critical care management of neurotrauma in children: new trends and perspectives. Childs Nerv Syst 1999;15:732–9
  5. Lucas S. M, Rothwell N. J, Gibson R. M. The role of inflammation in CNS injury disease. Br. J. Pharmacol 2006;147:232–40
  6. Hailer NP, Vogt C, Korf HW, Dehghani F. Interleukin-1beta exacerbates and interleukin-1 receptor antagonist attenuates neuronal injury and microglial activation after excitotoxic damage in organotypic hippocampal slice cultures. Eur J Neurosci 2005;21:2347–60
  7. Stahel PF, Shohami E, Younis FM, Kariya K, Otto VI, Lenzlinger PM, et al. Experimental closed head injury: analysis of neurological outcome, blood-brain barrier dysfunction, intracranial neutrophil infiltration, and neuronal cell death in mice deficient in genes for pro-inflammatory cytokines. J Cereb Blood Flow Metab 2000;20:369–80
  8. Yi JH, Hazell AS. Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury. Neurochem Int 2006;48:394–403
  9. Faden AI, Stoica B. Neuroprotection: challenges and opportunities. Arch Neurol 2007;64:794–800
  10. Leker RR, Shohami E. Cerebral ischemia and trauma-different etiologies yet similar mechanisms: neuroprotective opportunities. Brain Res Brain Res Rev 2002;39:55–73
  11. Marmarou A, Foda MA, van den Brink W, Campbell J, Kita H, Demetriadou K. A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanics. J Neurosurg 1994;80:291–300
  12. Adén U, Favrais G, Plaisant F, Winerdal M, Felderhoff-Mueser U, Lampa J, et al. Systemic inflammation sensitizes the neonatal brain to excitotoxicity through a pro-/anti-inflammatory imbalance: key role of TNFalpha pathway and protection by etanercept. Brain Behav Immun 2010;24:747–58
  13. Ekdahl CT, Claasen JH, Bonde S, Kokaia Z, Lindvall O. Inflammation is detrimental for neurogenesis in adult brain. Proc Natl Acad Sci U S A 2003;100:13632–7
  14. Jiang Y, Deacon R, Anthony DC, Campbell SJ. Inhibition of peripheral TNF can block the malaise associated with CNS inflammatory diseases. Neurobiol Dis 2008;32:125–32
  15. Kato K, Liu H,