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Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2006 / Cilt: 12 - Sayı: 1

Early enteral and glutamine enriched enteral feeding ameliorates healing of colonic anastomosis: experimental study

Erken enteral ve glutaminli enteral beslenmenin kolon anastomoz iyileşmesine etkisi: Deneysel çalışma

İbrahim GÖKPINAR
EMİN SAMİ GÜRLEYİK
Mevlüt PEHLİVAN
ÖMER ÖZCAN
İsmet ÖZAYDIN
Arif ASLANER
Yavuz DEMİRARAN
Mustafa GÜLTEPE
Pages
17–21
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Similar positive and useful, but weaker effects of glutamine supplementation are also valuables on collagen synthesis

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND: To investigate the effects of postoperative early enteral, and glutamine enriched enteral feeding on the healing of experimental colonic anastomosis.
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Key Findings & Data:METHODS: Forty Wistar-albino rats were equally divided into 4 groups.
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Conclusion & Impact:Similar positive and useful, but weaker effects of glutamine supplementation are also valuables on collagen synthesis
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Ameliyat sonrası bakım · Hidroksiprolin · Sıçan

Abstract

BACKGROUND: To investigate the effects of postoperative early enteral, and glutamine enriched enteral feeding on the healing of experimental colonic anastomosis. METHODS: Forty Wistar-albino rats were equally divided into 4 groups. Colonic transsection and anastomosis situated at distal left colon was performed on all animals. Groups 1 and 2; Animals received late (after 4th day postoperatively) enteral feeding. Groups 3 and 4; Animals received early (after 6th hours postoperatively) enteral feeding. Glutamine was added in enteral nutrition protocol in groups 2 (late) and 4 (early). The colonic segment including the anastomosis was excised at the end of 7th day postoperatively. Bursting pressure of the anastomosis and tissue hydroxyproline levels were determined. RESULTS: Bursting pressures levels were measured as 111.6 and 95.8 cm/water (p=0.022) in early and late nutrition groups respectively. Comparison of late enteral feeding groups (1 and 2) showed a significant difference in favor of group with glutamine (95.8 vs 138.5 cm/water; p<0.0001). Highest bursting pressure levels (139 and 138.5 cm/water) were measured in both early and late feeding groups with glutamine. Tissue hydroxyproline level in early enteral feeding group (2440.3 µg) was significantly (p=0.024) higher than late enteral feeding group (1509.6 µg). The differences were not statistically significant between other groups. Comparison of late enteral feeding groups (1 and 2) showed a considerable difference in favor of group with glutamine (1509.6 vs 1981.6 µg) but not statistically significant (p=0.276). CONCLUSION: Postoperative early enteral feeding significantly ameliorates the resistance of the anastomosis and collagen synthesis. Glutamine enrichment in nutritional protocol decreases and reverses disadvantages of late enteral feeding in point of the resistance of anastomosis. Similar positive and useful, but weaker effects of glutamine supplementation are also valuables on collagen synthesis

Özet

AMAÇ: Postoperatif dönemde total enteral beslenmenin erken uygulanması ve beslenme protokolüne glütamin eklenmesinin deneysel kolon anastomoz iyileşmesine etkisini araştırmak. GEREÇ-YÖNTEM: 40 Wistar-albino rat eşit sayıda denek içeren 4 gruba ayrıldı. Tüm deneklere distal sol kolon transseksiyonu ve anastomozu uygulandı. Grup 1 ve 2; geç total enteral beslenme (postoperatif 4. günden itibaren) uygulandı. Grup 3 ve 4; erken total enteral beslenme (postoperatif 6. saatten itibaren) uygulandı. Grup 2 (geç) ve 4 (erken)’te enteral beslenme protokolüne glütamin eklendi. Postoperatif 7. gün sonunda anastomoz içeren kolon segmenti çıkarılarak anastomoz patlama basıncı ve doku hidroksiprolin değerleri belirlendi. BULGULAR: Anastomoz patlama basıncı değerleri erken grupta 111.6, geç grupta 95.8 cm/su (p=0.022) bulundu. Geç enteral beslenme grupları (1 ve 2) karşılaştırıldığında glütaminli grup lehine anlamlı fark (95.8’ e 138.5 cm/su; p<0.0001) saptandı. Gerek erken, gerekse geç dönemde glütaminli enteral beslenmenin uygulandığı gruplarda en yüksek patlama basıncı değerleri (139 ve 138.5 cm/su) elde edildi. Doku hidroksiprolin miktarı erken beslenme grubunda (2440.3 µg), geç beslenme grubuna (1509.6 µg) göre anlamlı yüksek (p=0.024) bulundu. Diğer gruplar arası farklar istatistik açısından anlamsızdı. Geç enteral beslenme grupları (1 ve 2) karşılaştırıldığında glütaminli grup lehine anlamlı olmamakla (p=0.276) birlikte sayısal fark (1509.6 ya 1981.6 µg) saptandı. SONUÇLAR: Postoperatif dönemde total enteral beslenmenin erken uygulanması anastomoz direnci ve kollajen sentezini anlamlı olarak desteklemektedir. Anastomoz direnci açısından enteral yolun geç kullanıldığı durumda beslenme protokolüne glütamin eklenmesi, geç beslenme olumsuzluklarını azaltmakta ve geri döndürmektedir. Glütaminin benzer olumlu etkisi daha zayıf olmakla birlikte kollajen sentezi üzerinde de görülmektedir. Anahtar Kelimeler: Kolon anastomozu, enteral beslenme, glütamin, patlama basıncı, hidroksiprolin.

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Cite This Article

GÖKPINAR, İ., GÜRLEYİK, E. S., PEHLİVAN, M., ÖZCAN, Ö., ÖZAYDIN, İ., ASLANER, A., DEMİRARAN, Y., GÜLTEPE, M. (2006). Early enteral and glutamine enriched enteral feeding ameliorates healing of colonic anastomosis: experimental study. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 12 - Sayı: 1, 17–21. https://ajindex.com/articles/324474

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