Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2012 / Cilt: 18 - Sayı: 5

The role of blood S100B and lactate levels in minor head traumas in children and adults and correlation with brain computerized tomography

Çocuk ve erişkin minör kafa travmalarında kan S100B ile laktatın rolü ve bilgisayarlı beyin tomografisi ile korelasyonu

Pages
411–416
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Although the patients in our study group had minor head trauma, we do not consider S100B and lactate to be reliable markers for estimating progression.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:BACKGROUND In this study, we aimed to set levels of blood S100B and lactate and to determine any correlation with brain computerized tomography in minor head traumas in children and adults.
📊
Key Findings & Data:METHODS This clinical trial is a prospective study including 100 head trauma patients who applied to Ankara Training and Research Hospital emergency service.
💡
Conclusion & Impact:Although the patients in our study group had minor head trauma, we do not consider S100B and lactate to be reliable markers for estimating progression.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

BACKGROUND In this study, we aimed to set levels of blood S100B and lactate and to determine any correlation with brain computerized tomography in minor head traumas in children and adults. METHODS This clinical trial is a prospective study including 100 head trauma patients who applied to Ankara Training and Research Hospital emergency service. RESULTS In this study, cut-off ranges of 0.0-0.15 ug/ml and 0.9-1.7 mmol/L for blood S100B and lactate levels, respectively, were used. S100B level was higher than the cut-off range in 42% of patients and lactate level was higher in 56% of patients. No significant differences were determined between age groups. When the relation between S100B and lactate levels with brain CT was evaluated, no statistically significant relation was determined. CONCLUSION According to our results, in minor head traumas, the determination of elevated serum S100B and lactate levels cannot take the place of clinical examination and the use of cranial CT. Although the patients in our study group had minor head trauma, we do not consider S100B and lactate to be reliable markers for estimating progression.

Özet

AMAÇ Bu çalışmada, kan S100B ve laktat değerlerinin çocuk ve erişkin minör kafa travması sonrasında düzeylerinin belirlenmesi ve bilgisayarlı beyin tomografi (BBT) ile karşılaştırılması amaçlandı. GEREÇ VE YÖNTEM Bu çalışmada, Ankara Eğitim ve Araştırma Hastanesi Acil Servisi’ne başvuran, 100 kafa travması hastası geriye dönük olarak incelendi. BULGULAR S100B için kesim noktası 0-0,15 ve laktat için 0,9-1,5 alındığında; bireylerin %42’sinde S100B’nin yüksek ve %56’sında laktat’ın yüksek olduğu saptandı. Hastaların %12’si 18 yaş ve altı, %88’i 18 yaş üstündeydi. Yaş grupları arasında S100B ve laktat açısından anlamlı farklılık bulunamadı. BBT ile S100B ve laktat düzeyleri ilişkilendirildiğinde istatistiksel olarak anlamlı ilişki saptanmadı. SONUÇ Buna göre minör kafa travmalarında serum S100B ve laktat yüksekliği belirlenmesi klinik muayene veya BBT kullanımının yerini alamaz ve minör kafa travmalarında S100B ve laktatın prognoz tahminlerinde güvenilir işaretleyiciler olmadığı kanaatindeyiz.

🔖

Cite This Article

SEZER, A. A., AKINCI, E., ÖZTÜRK, M., ÇOŞKUN, F., YILMAZ, G., KARAKAŞ, A., TOKSÖZ, T. (2012). The role of blood S100B and lactate levels in minor head traumas in children and adults and correlation with brain computerized tomography. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 18 - Sayı: 5, 411–416. https://ajindex.com/articles/324150

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Gabbita SP, Scheff SW, Menard RM, Roberts K, Fugaccia I, Zemlan FP. Cleaved-tau: a biomarker of neuronal damage after traumatic brain injury. J Neurotrauma 2005;22:83-94
  2. Bouma GJ, Muizelaar JP, Stringer WA, Choi SC, Fatouros P, Young HF. Ultra-early evaluation of regional cerebral blood flow in severely head-injured patients using xenon-enhanced computerized tomography. J Neurosurg 1992;77:360-8
  3. Müller K, Townend W, Biasca N, Undén J, Waterloo K, Romner B, et al. S100B serum level predicts computed tomography findings after minor head injury. J Trauma 2007;62:1452-6
  4. Geyer C, Ulrich A, Gräfe G, Stach B, Till H. Diagnostic val- ue of S100B and neuron-specific enolase in mild pediatric traumatic brain injury. J Neurosurg Pediatr 2009;4:339-44
  5. Gazzolo D, Michetti F, Bruschettini M, Marchese N, Litua- nia M, Mangraviti S, et al. Pediatric concentrations of S100B protein in blood: age- and sex-related changes. Clin Chem 2003;49:967-70
  6. Filippidis AS, Papadopoulos DC, Kapsalaki EZ, Fountas KN. Role of the S100B serum biomarker in the treatment of children suffering from mild traumatic brain injury. Neuro- surg Focus 2010;29:E2
  7. Piazza O, Storti MP, Cotena S, Stoppa F, Perrotta D, Esposito G, et al. S100B is not a reliable prognostic index in paediatric TBI. Pediatr Neurosurg 2007;43:258-64
  8. Wiesmann M, Steinmeier E, Magerkurth O, Linn J, Gott- mann D, Missler U. Outcome prediction in traumatic brain injury: comparison of neurological status, CT findings, and blood levels of S100B and GFAP. Acta Neurol Scand 2010;121:178-85
  9. Hergenroeder GW, Redell JB, Moore AN, Dash PK. Bio- markers in the clinical diagnosis and management of trau- matic brain injury. Mol Diagn Ther 2008;12:345-58
  10. Oğün CO, Ustün ME, Duman A, Gürbilek M, Genç BO. Cor- relation between tissue lactate levels and electroencephalo- gram in evaluating the severity of experimental head trauma. Crit Care Med 2002;30:2123-8
  11. Zehtabchi S, Sinert R, Soghoian S, Liu Y, Carmody K, Shah L, et al. Identifying traumatic brain injury in patients with isolated head trauma: are arterial lactate and base deficit as helpful as in polytrauma? Emerg Med J 2007;24:333-5. 12. de Boussard CN, Lundin A, Karlstedt D, Edman G, Bartfai A, Borg J. S100 and cognitive impairment after mild trau- matic brain injury. J Rehabil Med 2005;37:53-7
  12. Nylén K, Ost M, Csajbok LZ, Nilsson I, Hall C, Blennow K, et al. Serum levels of S100B, S100A1B and S100BB are all related to outcome after sever