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Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2013 / Cilt: 19 - Sayı: 1

Bitkisel özlü Ankaferd Blood Stopper’in sıçanlarda derin dokulara uygulamada bölgesel ve sistemik dokulara etkilerinin histopatolojik olarak incelenmesi

Medicinal plant extract (Ankaferd Blood Stopper) application in deep tissue injuries in rats: histopathological investigation of the effect on regional and systemic tissues

Mehmet OKUMUŞ
KASIM ZAFER YÜKSEL
DAVUT ÖZBAĞ
Harun ÇIRALIK
Zeki YILMAZ
Yakup GÜMÜŞALAN
Vedat BAKAN
Ali Murat KALENDER
Pages
1–7
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There were no histopathological changes at the tissue level and no pathological effects in other organs tissues under light microscope, and the remote organ tissue re- mained clear.

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND This study was planned to evaluate both the histopathologi- cal changes under light microscope as well as the systemic organ effects following application of Ankaferd Blood Stopper® (ABS) (a mixture of five plant extracts) in an ani- mal model of deep tissue hemorrhage.
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Key Findings & Data:METHODS A total of 50 Wistar Albino rats were divided into five groups of 10 rats each.
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Conclusion & Impact:There were no histopathological changes at the tissue level and no pathological effects in other organs tissues under light microscope, and the remote organ tissue re- mained clear.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

BACKGROUND This study was planned to evaluate both the histopathologi- cal changes under light microscope as well as the systemic organ effects following application of Ankaferd Blood Stopper® (ABS) (a mixture of five plant extracts) in an ani- mal model of deep tissue hemorrhage. METHODS A total of 50 Wistar Albino rats were divided into five groups of 10 rats each. The rats underwent femoral vein puncture and were treated with ABS tampon, ABS spray, or Surgi- cel, and one group was left untreated. After two weeks, each group underwent partial tissue excision from the same femo- ral region as well as from the brain, heart, kidney, and liver. RESULTS The specimens from all groups were obtained from the femoral region after two weeks and evaluated under light microscope. The light microscope revealed no histopatho- logical changes in neurovascular structures or in deep con- nective tissues in any of the groups. CONCLUSION ABS provided hemostasis and was observed to stop bleed- ing. There were no histopathological changes at the tissue level and no pathological effects in other organs tissues under light microscope, and the remote organ tissue re- mained clear.

Özet

AMAÇ Bu çalışmada, Ankaferd Blood Stopper® (ABS) (beş bitki özü karışımı), bir hayvan modelinde derin doku kanamalarına uygulandığında, histopatolojik değişikliklerin ve sistemik organ etkilerinin ışık mikroskobu altında değerlendirilmesi planlandı. GEREÇ VE YÖNTEM Toplamda 50 adet Wistar Albino sıçanlar her birinde 10’ar adet olmak üzere 5 gruba ayrıldı. Sıçanlarda femoral ven delinerek ABS tampon, ABS sprey, Surgicel ile tedavi edildi, bir grup hiç tedavi almadı. İki hafta sonra her gruptan aynı femoral bölgeden ve aynı zamanda beyin, kalp, böb rek ve karaciğerden kısmi doku alındı. BULGULAR İki hafta sonra tüm gruplarda femoral bölgeden elde edilen örnekler ışık mikroskobu ile değerlendirildi. Tüm gruplarda nörovasküler yapılarda veya derin bağ dokularında ışık mikroskobu incelemesinde herhangi bir histopatolojik de- ğişiklik ortaya çıkmadı. SONUÇ Ankafer Blood Stopper’in hemostazı sağladığı ve kana- mayı durdurduğu gözlemlendi. Işık mikroskobunda doku düzeyinde histopatolojik değişiklikler ve diğer organlarda patolojik etkiler yoktu, uzak organ dokuları temizdi.

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Cite This Article

OKUMUŞ, M., YÜKSEL, K. Z., ÖZBAĞ, D., ÇIRALIK, H., YILMAZ, Z., GÜMÜŞALAN, Y., BAKAN, V., KALENDER, A. M. (2013). Bitkisel özlü Ankaferd Blood Stopper’in sıçanlarda derin dokulara uygulamada bölgesel ve sistemik dokulara etkilerinin histopatolojik olarak incelenmesi. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 19 - Sayı: 1, 1–7. https://ajindex.com/articles/324101

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