Comparison of warm fluid and cold fluid resuscitation during uncontrolled hemorrhagic shock model in rats

P value of ≤0.05 was considered statistically significant.RESULTS: Cold fluid resuscitation decreased survival time due to increased rate and volume of hemorrhage, acidosis, hypothermia, lactate, and base deficit and decreased blood pressure and hematocrit.CONCLUSION: There is a great need for further experimental and clinical trials on fluid resuscitation in trauma in order to define which fluid should be administered, temperature of the fluid, quantity to be delivered, and duration

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND: This study was designed to compare the effects of resuscitation with cold and warm fluid on survival time, rate and volume of hemorrhage, hemodynamics, hypothermia, coagulopathy, acid-base balance, hematocrit, lactate, and base deficit during uncontrolled hemorrhagic shock (HS) model in rats.

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Key Findings & Data:METHODS: HS model was created with splenic vascular and parenchymal injury in 29 rats under ketamine and xylazine anesthesia.

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Conclusion & Impact:P value of ≤0.05 was considered statistically significant.RESULTS: Cold fluid resuscitation decreased survival time due to increased rate and volume of hemorrhage, acidosis, hypothermia, lactate, and base deficit and decreased blood pressure and hematocrit.CONCLUSION: There is a great need for further experimental and clinical trials on fluid resuscitation in trauma in order to define which fluid should be administered, temperature of the fluid, quantity to be delivered, and duration

🔬Design:Modeling & Simulation

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

BACKGROUND: This study was designed to compare the effects of resuscitation with cold and warm fluid on survival time, rate and volume of hemorrhage, hemodynamics, hypothermia, coagulopathy, acid-base balance, hematocrit, lactate, and base deficit during uncontrolled hemorrhagic shock (HS) model in rats. METHODS: HS model was created with splenic vascular and parenchymal injury in 29 rats under ketamine and xylazine anesthesia. Thirty minutes after the hemorrhage, the rats were randomized to receive 14.5 mL/kg 0.9% sodium chloride solution at either 24ºC (Group 1; n=9) or 4ºC (Group 2; n=10) for 20 minutes. Groups 1 and 2 were compared with group that did not receive fluid (Group 3; n=10). Statistical data were represented as mean±SD. SPSS for Windows, Version 15.0 (SPSS, Inc., Chicago, IL, USA) software, Bonferroni-adjusted Mann-Whitney U test and Kaplan-Meier procedure were used to perform statistical data analysis. P value of ≤0.05 was considered statistically significant.RESULTS: Cold fluid resuscitation decreased survival time due to increased rate and volume of hemorrhage, acidosis, hypothermia, lactate, and base deficit and decreased blood pressure and hematocrit.CONCLUSION: There is a great need for further experimental and clinical trials on fluid resuscitation in trauma in order to define which fluid should be administered, temperature of the fluid, quantity to be delivered, and duration

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Cite This Article

DİLMEN, S., ERYILMAZ, M., BALKAN, S. M., SERDAR, M., DURUSU, M., YILDIRIM, A. O., DİLMEN, S. A. (2017). Comparison of warm fluid and cold fluid resuscitation during uncontrolled hemorrhagic shock model in rats. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 23 - Sayı: 4, 287–293. https://ajindex.com/articles/323995

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References (15)

Faist E, Baue AE, Dittmer H, Heberer G. Multiple organ failure in polytrauma patients. Journal of Trauma 1983;23:775–8
Norio H, Takasu A, Kawakami M, Saitoh D, Sakamoto T, Okada Y. Rapid body cooling by cold fluid infusion prolongs survival time during uncontrolled hemorrhagic shock in pigs. J Trauma 2002;52:1056–61
Ertekin C. Approach to the patient with multiple trauma. Turkish Journal of Intensive Care Medicine 2002;2(2):77–87
Bilkovski RN, Rivers EP, Horst HM. Targeted resuscitation strategies after injury. Curr Opin Crit Care 2004;10:529–38
Mapstone J, Roberts I, Evans P. Fluid resuscitation strategies: a systematic review of animal trials. J Trauma 2003;55:571–89
Kliegel A, Losert H, Sterz F, Kliegel M, Holzer M, Uray T, et al. Cold simple intravenous infusions preceding special endovascular cooling for faster induction of mild hypothermia after cardiac arrest--a feasibility study. Resuscitation 2005;64:347–51
Kämäräinen A, Virkkunen I, Tenhunen J, Yli-Hankala A, Silfvast T. Induction of therapeutic hypothermia during prehospital CPR using icecold intravenous fluid. Resuscitation 2008;79:205–11
Polderman KH, Rijnsburger ER, Peerdeman SM, Girbes AR. Induction of hypothermia in patients with various types of neurologic injury with use of large volumes of ice-cold intravenous fluid. Crit Care Med 2005;33:2744–51
Bernard S, Buist M, Monteiro O, Smith K. Induced hypothermia using large volume, ice-cold intravenous fluid in comatose survivors of out-ofhospital cardiac arrest: a preliminary report. Resuscitation 2003;56:9– 13
Wu X, Kochanek PM, Cochran K, Nozari A, Henchir J, Stezoski SW, et al. Mild hypothermia improves survival after prolonged, traumatic hemorrhagic shock in pigs. J Trauma 2005;59:291–301
Dogan Z. Retrospective Analysis of the pediatric patients with trauma presenting to emergency service. Emergency medicine specialty thesis. Cumhuriyet University Medical Faculty Emergency Department, Sivas 2008
Little RA. 1988 Fitts lecture: heart rate changes after haemorrhage and injury--a reappraisal. J Trauma 1989;29:903–6
Secher NH, Sander Jensen K, Werner C, Warberg J, Bie P. Bradycardia during severe but reversible hypovolemic shock in man. Circ Shock 1984;14:267–74
Kline JA. Shock. In: Marx JA, editor. Rosens’s Emergency Medicine Concepts and Clinical Practice. 7th ed. Mosby: St Louis; 2010. p. 34–41
Durusu M, Eryilmaz M, Oztürk G, Menteş O, Ozer T, Deniz T. Comparison of permissive