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Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2014 / Cilt: 20 - Sayı: 5

Thymoquinone attenuates trauma induced spinal cord damage in an animal model

Nilgün ÜSTÜN
Mustafa ARAS
TÜMAY ÖZGÜR
HAMDULLAH SUPHİ BAYRAKTAR
Fatih SEFİL
RAİF ÖZDEN
Abdullah Erman YAĞIZ
Pages
328–332
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Thus, TQ needs to be taken into consideration, for it may have a neuroprotective effect in trauma induced spinal cord damage

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND: Spinal cord injury (SCI) is one of the most devastating conditions leading to neurological impairment and disabilities.
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Key Findings & Data:METHODS: Twenty-four male Wistar albino rats were randomly divided into 4 groups: control group; SCI group; SCI-induced and 10 mg/kg/day TQ administered group; SCI-induced and 30 mg/kg/day TQ administered group.
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Conclusion & Impact:Thus, TQ needs to be taken into consideration, for it may have a neuroprotective effect in trauma induced spinal cord damage
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

BACKGROUND: Spinal cord injury (SCI) is one of the most devastating conditions leading to neurological impairment and disabilities. The aim of the study was to investigate the potential neuroprotective effect of thymoquinone (TQ) histopathologically in an experimental model of traumatic spinal cord injury (SCI). METHODS: Twenty-four male Wistar albino rats were randomly divided into 4 groups: control group; SCI group; SCI-induced and 10 mg/kg/day TQ administered group; SCI-induced and 30 mg/kg/day TQ administered group. TQ was given as intraperitoneal for three days prior to injury and four days following injury. Spinal cord segment between T8 and T10 were taken for histopathologic examination. Hemorrhage, spongiosis and liquefactive necrosis were analyzed semiquantatively for histopathological changes. RESULTS: Administration of TQ at a dose of 10 mg/kg did not cause any significant change on the histological features of neuronal degeneration as compared to the SCI group (p=0.269); however, 30 mg/kg TQ significantly decreased the histological features of spinal cord damage below that of the SCI group (p=0.011). CONCLUSION: Data from this study suggest that TQ supplementation attenuates trauma induced spinal cord damage. Thus, TQ needs to be taken into consideration, for it may have a neuroprotective effect in trauma induced spinal cord damage

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Cite This Article

ÜSTÜN, N., ARAS, M., ÖZGÜR, T., BAYRAKTAR, H. S., SEFİL, F., ÖZDEN, R., YAĞIZ, A. E. (2014). Thymoquinone attenuates trauma induced spinal cord damage in an animal model. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 20 - Sayı: 5, 328–332. https://ajindex.com/articles/323853

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