AI Summary & Key Takeaways
AI InsightIn conclusion, while our results concerning homogenous sub-population of patients with stage IB grade II endometrial cancer seem to support the use of postoperative adjuvant radiotherapy, larger and more detailed prospective studies are required for determination of its exact prognostic value.
📌 3 Key Takeaways
Abstract
Present study was designed to evaluate potential risks and benefits of adjuvant radiotherapy in selected patients with intermediate- risk endometrial cancer. A total of 100 patients with stage IB grade II endometrial cancer followed up in Radiation Oncology Clinic at Dr. Lutfi Kirdar Education and Research Hospital were evaluated retrospectively to determine the influence of postsurgical adjuvant radiotherapy on disease-free survival, local recurrences and locally-relaps free survival. Side effects related to adjuvant radiotherapy were also evaluated. Forty-seven (47%) patients were determined to undergo total abdominal hysterectomy + bilateral salphingo-oopherectomy and 53 (53%) patients, total abdominal hysterectomy + bilateral salphingo-oopherectomy + pelvic lymph node dissection. Postsurgical adjuvant radiotherapy was administered in 77 patients (77%), while the surgery was the sole medical intervention for 23 patients (23%). The median follow-up period was 40.5 months (range: 6-139) Five-year disease-free survival (96.6% vs. 80.5%; p< 0.01) and local control (98.6% vs. 80.5%; p<0.05) were better in patients who were administered postoperative radiotherapy compared to patients without postoperative radiotherapy. In conclusion, while our results concerning homogenous sub-population of patients with stage IB grade II endometrial cancer seem to support the use of postoperative adjuvant radiotherapy, larger and more detailed prospective studies are required for determination of its exact prognostic value.
Özet
Bu çalışma orta risk endometrium kanserli hasta populasyonunda adjuvant radyoterapinin potansiyel risk ve yararlarını değerlendirmek amacıyla tasarlandı. Stage IB grade II endometrium kanseri tanısıyla Dr. Lutfi Kirdar Eğitim ve Araştırma Hastanesi Radyasyon Onkolojisi Kliniğinde izlenmekte olan toplam 100 hastada postoperatif adjuvant radyoterapinin hastalıksız sağ kalım, lokal rekürrens ve lokal kontrol oranlarına etkisi retrospektif olarak belirlendi. Adjuvan radyoterapiye yönelik yan etkiler de ayrıca değerlendirildi. Toplam 47 (%47) hastada total abdominal histerektomi+bilateral salfingo-ooferektomi ve 53(53%) hastada ise total abdominal histerektomi+bilateral salfingo-ooferektomi+ pelvik lenf nodu diseksiyonu uygulandığı saptandı. Postoperatif adjuvan radyoterapi 77 (%77) hastada, cerrahi ise 23 (%23) hastada başlıca tedavi yöntemi olup, medyan izlem süresi 40.5 ay (6-139) olarak bulundu. Hastalıksız 5 yıllık sağkalım (%96.6 ila %80.5; p< 0.01) ve lokal kontrol (%98.6 ila %80.5; p< 0.05) oranlarının postoperatif radyoterapi uygulanan hastalarda uygulanmayanlara göre belirgin şekilde daha yüksek olduğu bulundu. Sonuç olarak, stage IB grade II endometrium kanseri hastalarından oluşan homojen bir populasyonuna yönelik olan bulgularımız, bu hastalarda postoperatif adjuvant radyoterapi kullanımı destekler nitelikte görünse de, postoperatif adjuvant radyoterapinin gerçek prognostik değerinin anlaşılabilmesi için daha geniş ölçekli ve daha kapsamlı çalışmalara gereksinim vardır.