AI Summary & Key Takeaways
AI InsightThis variations were compatible with the poor prognosis premenopausal patients with breast cancer.
📌 3 Key Takeaways
Abstract
In Turkish patients with breast cancer variations of prognostic factors were examined according to the menopausal status. In addition, molecular variations were investigated according to the menopausal status. A total of 1449 patients was enrolled from Akdeniz University Hospital of Medical School and Kayseri Education and Research Hospital. The patients were divided into three groups as menopausal status (pre, peri and postmenopausal) and into four groups according to molecular types (luminal A,luminal B, HER 2 like and Unclassified-Basal like). Patients were retrospectively recorded in the SPSS software. There was significant difference in the estrogen and cerbB2 hormon receptor positivity between premenopausal and postmenopausal groups (p=0.003 and 0.032). Estrogen receptor ratio was higher in postmenopausal group, and CerbB2 receptor ratio was higher in premenopausal group. Luminal A molecular subtype was the dominant subgroup. Compared to the other two groups, in premenopausal group, the ratio of HER 2 Like and Unclassified-Basal like molecular type were higher and the ratio of the luminal types were lower. Luminal A was the dominant subgroup in Turkish patients with breast cancer. Rate of molecular types was determined to be varied with menopausal status. This variations were compatible with the poor prognosis premenopausal patients with breast cancer.
Özet
Türk meme kanserli hastalarda menopozal duruma göre prognostik faktörlerin farklılı¤ı incelendi. Ayrıca moleküler farklılıklar menopozal duruma göre araştırıldı. Akdeniz Üniversitesi ve Kayseri E¤itim ve Araştırma Hastanesinden toplam 1449 hasta kaydedildi. Hastalar menopozal duruma göre üç guruba (pre, peri ve postmenopozal) ve moleküler tiplere göre dört guruba (luminal A, luminal B, Her 2 Like ve Sınışandırılamayan-Basal like) ayrıldı. Hastalar retrospektif olarak SPSS istatistik programına kaydedildi. Moleküler gruplarda Basal Like ve Unclassified grup aynı grup içine alındı. Premenopozal ve postmenopozal gruplar arasında östrojen ve CerbB2 pozitişi¤i için anlamlı fark mevcuttu (p de¤eri 0.003 ve 0.032, sırası ile). Postmenopozal grupta östrojen reseptörü, premenopozal grupta Cerb B2 oranı daha yüksek idi. Luminal A moleküler alt tip baskın olan altgruptu. Di¤er iki gurupla karşılaş-tırıldı¤ında premenopozal gurupta HER 2 Like ve Sınışandırılamayan-Basal Like moleküler tiplerin oranı daha fazla, luminal tiplerin oranı daha düşük idi. Türk meme kanserli hastalarda Luminal A baskın olan subgruptu. Moleküler tiplerin oranlarının menopozal status ile farklılık gösterdi¤i belirlendi. Bu farklılık premenopozal meme kanserli hastaların kötü prognozu ile uyumluluk göstermekte idi.