Journals / Uluslararası Hematoloji-Onkoloji Dergisi / 2012 / Cilt: 22 - Sayı: 4

Primer santral sinir sistemi lenfomalı hastaların özellikleri ve sonuçları: Tek bir merkez deneyimi ve literatür özeti

Characteristics and outcomes of patients with primary central nervous system lymphoma: A single center experience and review of the literature

Pages
227–232
DOI
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⚡ TL;DR(Too Long; Didn't Read)

The median overall survival (OS) was 8 months (minimum: 1 months, maximum: 15 months) and mean OS was 8.4 ± 5.41 months.

📌 3 Key Takeaways

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Objective & Hypothesis:This retrospective study was designed to review the clinicopathological characteristics and outcomes of primary central nervous system lymphoma (PCNSL) cases at our institute.
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Key Findings & Data:Patients diagnosed with PCNSL at our institute from August 2010 to December 2011 were evaluated.
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Conclusion & Impact:The median overall survival (OS) was 8 months (minimum: 1 months, maximum: 15 months) and mean OS was 8.4 ± 5.41 months.
🔬Design:Review & Systematic Survey
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Abstract

This retrospective study was designed to review the clinicopathological characteristics and outcomes of primary central nervous system lymphoma (PCNSL) cases at our institute. Patients diagnosed with PCNSL at our institute from August 2010 to December 2011 were evaluated. During this period, a total of 5 cases have been diagnosed with PCNSL. Parieto-occipital lobe was the most common site of involvement. Diffuse large B-cell lymphoma (DLBCL) was the most common histological pattern. 4 patients were treated with 3.0 g/m2 methotrexate (MTX) intravenously concomitant with intraventricular 15 mg MTX and 1 patient was treated with radiotherapy (RT). The median overall survival (OS) was 8 months (minimum: 1 months, maximum: 15 months) and mean OS was 8.4 ± 5.41 months. As mentioned previous studies, MTX-based chemotherapy regimens are still the most effective treatment option in this patient population.

Özet

Bu retrospektif çalışma bölümümüzdeki primer santral sinir sistemi lenfoma (PSSSL) vakalarının klinik ve patolojik özelliklerini ve sonuçlarını özetlemek için dizayn edildi. Ağustos 2010 ile Aralık 2011 tarihleri arasında, bölümümüzde PSSSL tanısı almış hastalar değerlendirildi. Bu zaman aralığında totalde 5 hasta PSSSL tanısı almıştır. En sık tutulan bölge parieto-oksipital lob idi. En sık histolojik tip diffüz büyük B hücreli lenfoma (DBBHL) idi. Hastaların dördü 3.0 g/m2 intravenöz metotrexate (MTX) ve eş zamanlı intraventriküler 15 mg MTX ile ve bir hasta da radyoterapi (RT) ile tedavi edildi. Ortanca tüm sağkalım 8 ay (minimum: 1 ay, maximum: 15 ay) ve ortalama tüm sağkalım 8.4 ± 5.41 ay idi. Daha önceki çalışmalarda bahsedildiği üzere MTX tabanlı kemoterapi rejimleri bu hasta grubunda halen en etkili tedavi şeklidir.

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Cite This Article

KORKMAZ, S., ŞENCAN, M., ÖZÜM, Ü., KARAADAĞ, Ö. (2012). Primer santral sinir sistemi lenfomalı hastaların özellikleri ve sonuçları: Tek bir merkez deneyimi ve literatür özeti. Uluslararası Hematoloji-Onkoloji Dergisi, Cilt: 22 - Sayı: 4, 227–232. https://ajindex.com/articles/323117

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