Journals / Uluslararası Hematoloji-Onkoloji Dergisi / 2006 / Cilt: 16 - Sayı: 1

Prognostic factors of non-hodgkin lymphoma

Non-hodgkin lenfomada prognostik parametreler

Pages
27–31
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Age, B symptoms, performance status, baseline lactate dehydrogenase (LDH), haemoglobin and albumin levels have a statistically significant effect on overall survival on univariate analysis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Predicting the prognosis before treatment is very important in non-Hodgkin lymphoma (NHL) patients.
📊
Key Findings & Data:In the presented study we targeted to evaluate the significant prognostic parameters that may have an effect on survival in NHL.
💡
Conclusion & Impact:Age, B symptoms, performance status, baseline lactate dehydrogenase (LDH), haemoglobin and albumin levels have a statistically significant effect on overall survival on univariate analysis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Geriyedönük çalışma · Seyir · Tıbbi kayıtlar

Abstract

Predicting the prognosis before treatment is very important in non-Hodgkin lymphoma (NHL) patients. In the presented study we targeted to evaluate the significant prognostic parameters that may have an effect on survival in NHL. One hundred seventy four NHL patients were analyzed from their hospital files, retrospectively. Age, B symptoms, performance status, baseline lactate dehydrogenase (LDH), haemoglobin and albumin levels have a statistically significant effect on overall survival on univariate analysis. In our study group, the worse prognostic factors were established as to be age older than 60 years, higher than normal LDH levels, poor performance status, low albumin levels, anemia and presence of B symptoms.

Özet

Non-Hodgkin lenfomalı (NHL) hastalarda tedavi planı öncesinde prognozu tahmin etmek büyük önem taşımaktadır. Bu çalışmada, NHL'li hasta grubumuzda, sağkalıma etki edebilecek anlamlı prognostik parametreleri tespit etmeyi amaçladık. Yüz yetmiş dört NHL hasta kayıtları retrospektif olarak incelendi. Genel sağkalım univariate analizinde yaş, B semptomu, performans durumu, bazal serum laktat dehidrogenaz (LDH), hemoglobin ve albumin düzeylerinin yaşam süresine istatistiksel olarak anlamlı etkisi mevcuttu. Hasta grubumuzda 60 yaş üzeri, LDH yüksekliği, performans durumu düşüklüğü, albumin düşüklüğü, anemi ve B semptomu varlığı kötü prognostik parametreler olarak tespit edildi.

🔖

Cite This Article

UNCU, D., ABALI, H., ÖZDEMİR, N., BUDAKOĞLU, B., GÜLER, T., ÖKSÜZOĞLU, B. Ç., ZENGİN, N. (2006). Prognostic factors of non-hodgkin lymphoma. Uluslararası Hematoloji-Onkoloji Dergisi, Cilt: 16 - Sayı: 1, 27–31. https://ajindex.com/articles/323053

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Cancer. Principles and Practice of Oncology: Third edition 1989:Ed. Vincent T de Vita Jr, Samuel Helman
  2. Temel iç Hastalıkları: Non Hodgkin lenfoma. 1.baskı Yamaç K, İliçin G, Ünal S. Ankara. 1996;1298-1312
  3. Dinçol D, Akbulut H, İçli F, et al. Results of cyclophosphamide, doxorubisin, vincristine and prednisone (CHOP) ± bleomycin treatment and evaluation of prognostic factors in Turkey. Oncology 1997;54:376-379
  4. Kuzu I. Hodgkin dışı lenfoma sınıflamasında son gelişmeler. Hematoloji-Onkoloji. 2000; 2: 256-267
  5. Shipp MA. Prognostic factors in agressive non- Hodgkin’s lymphoma: who has high risk disease?. Blood 1994; 83:1165-1173
  6. Sarpel SC, Paydaş S, Tuncer I, et al. Non- Hodgkin's Iymphomas in Turkey. Cancer 62:1653-1657, 1988
  7. Firat D. Cancer Statistics in Turkey. Ankara, Turkey: Turkish Association for Cancer Research and Control, 1982;23
  8. El-Akkad SM, Amer MH, Lin GS, et al. Pattern of cancer in Saudi Arabs referred to King Faisal Specialist Hospital. Cancer 58:1172-1178, 1986
  9. Azar Ha. Cancer in Lebanon and the Near East. Cancer 15:66-78, 1962
  10. Nasr LA, Tawfik HN, El-Einen MA. Lymphoreticular tumors and leukemias in Egypt. J Natl Cancer Inst 50:1619-1621, 1973
  11. American Cancer Society. Cancer statistics. CA 36:9-25, 1986
  12. Yuen AR. Progress in the non-Hodgkin’s lymphomas. Ann Oncol 10 (Suppl 6):19-22, 1999
  13. Fedrico M, Vitolo U, Zinzani PL. Prognosis of follicular lymphoma: a predictive model based on a retrospective analysis of 987 cases. Blood 95:783-789, 2000
  14. Gallacher CJ, Gregory WM, Jones AE, et al. Follicular lymphoma: prognostic factors for response and survival. J Clin Oncol 4:1470- 1474, 1986
  15. Litam P, Swan F, Cabanillas F, et al. Prognostic value of beta-2-microglobulin in low grade lymphoma. Ann İntern Med 114:855-858, 1991
  16. Bremnes RM, Bremnes Y, Donnem T. High grade NHL treated in Northern Norway. Acta Oncol 38:117-124, 1999
  17. Maksymiuk AW, Bratvold JS, Ezzat W. Non Hodgkins Lymphoma in Saskatchewan. Cancer 73(3):711-719, 1994.