AI Summary & Key Takeaways
AI InsightThe median follow-up period was 50 month and 5 year overall survival rate was 68.34% and disease free survival rate was 63.82%.
📌 3 Key Takeaways
Abstract
We aimed to investigate the factors affecting recurrence and survival rate in patients with stage II-III rectum carcinomas. Between January 1998 and December 2003, 164 patients having chemoradiotherapy with stage II-III rectum carcinomas were retrospectively evaluated in this study. We recorded the clinical/pathological data and surgical and medical therapeutic options. Median age 56 (range 22-82), 86 (52.4%) female and 78 (47.6%) male patients were included in this study. 70 patients (42.7%) were stage II, 94 patients (57.3%) were stage III according to the TNM classification. We carried out the 5-Fluorouracil / Folic acid (FUFA) as chemotherapeutic agents and radiotherapy protocol in all patients. Local recurrence was seen in 16 (9.8%), distant metastases in 35 (21.3%) patients, and both local recurrence and distant metastases were seen in 6 (3.7%) patients. The liver was the most involved organ for distant metastases. While involved lymph nodes, stage, histological grade, and surgical procedures played a statistically significant role on local recurrence, only stage was seen to have an important role on distant metastases. The median follow-up period was 50 month and 5 year overall survival rate was 68.34% and disease free survival rate was 63.82%. When analyzing the parameters effecting the overall and disease free survivals; involved lymph node, stage, histological grade, and surgical therapeutic option were found to be statistically significant in one variable analyses method. Multivariate analysis revealed that stage, histological grade and surgical procedures effects general survival rate. Only histological grade and surgical procedure were found to be effective in disease free survival in multivariate analyses. In considering these results, the type of surgical procedure and histological grade has an important role in local recurrence and disease free survival.
Özet
Adjuvan kemoradyoterapi uygulanan evre II-III rektum kanserli hastalarda sağkalım ve nüks oranları üzerine etkili faktörlerin değerlendirilmesi amaçlandı. Kliniğimize 1 Ocak 1998 – 31 Aralık 2003 tarihleri arasında başvurarak kemoradyoterapi uygulanan 164 hasta retrospektif olarak değerlendirilmiştir. Hastaların klinik ve patolojik bulguları ve cerrahi, kemoradyoterapi uygulamaları kaydedildi Hastaların medyan yaşı 56 (aralık 22-82), 86’sı (%52.4) kadın, 78’i (%47,6) erkekti. TNM evrelemesine göre hastaların 70’i (%42.7) evre II, 94’ü (%57.3) evre III’tü. Tüm hastalara 5-Fluorourasil / Folik asit (FUFA) kemoterapisi ve radyoterapi uygulanmıştı. Takipte 16 (%9.8) hastada lokal nüks, 35 (%21.3) hastada uzak metastaz ve 6 (%3,7) hastada ise lokal nüks ve uzak metastaz birlikte görülmüştü. En sık uzak metastaz yeri karaciğerdi. Lokal nüks üzerinde etkli parametrelerde lenf nodu tutulumu, evre, histolojik grade ve cerrahi tipi istatistiksel olarak anlamlı iken uzak metastaz üzerine yalnızca evre istatistiksel olarak etkili bulundu. Medyan takip 50 ay olup 5 yıllık genel sağkalım %68.34 ve hastalıksız sağkalım %63.82 idi. Genel ve hastalıksız sağkalımı etkileyen parametreler değerlendirildiğinde tek değişkenli analizde lenf nodu tutulumu, evre, cerrahi tipi ve histolojik grad istatistiksel olarak anlamlı bulundu. Çok değişkenli analizde ise genel sağkalımı evre, histolojik grad ve cerrahi tipi etkilerken hastalıksız sağkalımda yalnızca cerrahi tip ve histolojik grad istatistiksel anlamlı bulundu. Sonuç olarak cerrahi tipi ve histolojik grad lokal nüks ve hastalıksız sağkalımı anlamlı olarak etkilemektedir.