Journals / Uluslararası Hematoloji-Onkoloji Dergisi / 2008 / Cilt: 18 - Sayı: 3

Radyasyona bağlı brakial pleksus hasarının patofizyolojisi ve tedavi seçenekleri

Pathophysiology and treatment of radiation-ınduced brachial plexopathy

Pages
180–185
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In grade 3 and 4 injuries, surgical interventions to prevent fibrosis of the vascular supply to the nerves and to release nerves from fibrotic constrictions should be considered.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Radiation therapy is a well proven effective treatment modality in the management of various cancers.
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Key Findings & Data:Currently, there is no generally accepted treatment method, but non-narcotic and narcotics and anesthetic interventions for grade 1 and 2 lesions are suggested.
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Conclusion & Impact:In grade 3 and 4 injuries, surgical interventions to prevent fibrosis of the vascular supply to the nerves and to release nerves from fibrotic constrictions should be considered.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Anatomi · Radyoterapi · Brakiyal pleksus nöröpatisi

Abstract

Radiation therapy is a well proven effective treatment modality in the management of various cancers. However, radiation therapy has potentially adverse effects on several tissues including central and peripheral nervous systems. Radiation-induced brachial plexopathy is a rare but challenging complication of RT in patients undergoing chest, axillary, and neck irradiation because of myriad of primary or malignant tumors of these region. It is a progressive disease state which may lead to devastating sensorial and motor malfunctions. Currently, there is no generally accepted treatment method, but non-narcotic and narcotics and anesthetic interventions for grade 1 and 2 lesions are suggested. In grade 3 and 4 injuries, surgical interventions to prevent fibrosis of the vascular supply to the nerves and to release nerves from fibrotic constrictions should be considered.

Özet

Radyoterapi birçok kanser türünün tedavisinde başarıyla kullanılmakta olan tedavi seçeneklerinden biridir. Ancak, radyoterapi merkezi ve periferik sinir sistemini de içine alan bir çok dokuda hasar oluşturma potansiyeline sahiptir. Bunlardan biri de nadiren görülmesine rağmen önlenmesi oldukça güç olan brakiyal pleksus hasarıdır. Radyasyona bağlı brakiyal pleksus hasarı göğüs, aksilla ve boyunu kapsayan alana primer veya metastatik tümörlerin tedavisi amacıyla radyoterapi uygulanan hastalarda görülmektedir. Pleksus hasarı genellikle progresif bir seyir izleyerek duyusal ve motor bozukluklara yol açabilir. Günümüzde literatürde genel kabul görmüş bir tedavi seçeneği bulunmamaktadır. Ancak, genel olarak uygulanacak tedavi modaliteleri daha çok hasarın derecesine göre seçilmektedir. Grad 1 ve 2 pleksus hasarlarında narkotik ve narkotik olmayan ağrı kesicilerin kullanılması ve anestetik girişimler yeterli olmaktayken, grad 3 ve 4 hasarlarda sinirin fibrotik dokulardan serbestleştirilmesi ve sinirin kanlanmasını sağlayan vasküler yapılarda fibrozis gelişmesini önlemeye yönelik cerrahi girişimlerin uygulanması gerekmektedir.

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Cite This Article

TOPKAN, E., ÖNAL, H. C., YAVUZ, M. N., YAVUZ, A. A. (2008). Radyasyona bağlı brakial pleksus hasarının patofizyolojisi ve tedavi seçenekleri. Uluslararası Hematoloji-Onkoloji Dergisi, Cilt: 18 - Sayı: 3, 180–185. https://ajindex.com/articles/323029

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