Journals / Uluslararası Hematoloji-Onkoloji Dergisi / 2014 / Cilt: 24 - Sayı: 2

Apokrin Farklılaşma Gösteren Karsinomlar: Türk Hastalarda Özel Olmayan Tip İnvaziv Meme Karsinomu ile Klinikopatolojik Özelliklerinin Karşılaştırılması

Carcinomas with Apocrine Differentiation: Comparison of Clinicopathologic Features with Invasive Breast Carcinoma of No Special Type (NST) in Turkish Patients

Pages
118–122
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Prognostic features such as overall survival period and relapse – free survival period were also studied; but only for a limited follow – up period with an average of approximately 30 months.

📌 3 Key Takeaways

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Objective & Hypothesis:When a total of 2488 Turkish patients were taken into consideration, carcinomas with apocrine differentiation accounted for 0.7% of invasive breast carcinomas.
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Key Findings & Data:Parameters such as patient’s age, tumor size, nodal metastasis, lymphatic – vascular invasion, immunohistochemical expressions of estrogen receptor, progesterone receptor, HER2 status were documented and compared with invasive ductal carcinoma of no special type.
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Conclusion & Impact:Prognostic features such as overall survival period and relapse – free survival period were also studied; but only for a limited follow – up period with an average of approximately 30 months.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

When a total of 2488 Turkish patients were taken into consideration, carcinomas with apocrine differentiation accounted for 0.7% of invasive breast carcinomas. The aim of this study was to evaluate clinicopathologic features of this rare type breast carcinoma in Turkish population. To our knowledge, our study has a unique specialty as having broadest group of Turkish patients with apocrine carcinoma, so far. Parameters such as patient’s age, tumor size, nodal metastasis, lymphatic – vascular invasion, immunohistochemical expressions of estrogen receptor, progesterone receptor, HER2 status were documented and compared with invasive ductal carcinoma of no special type. Against 20 cases of apocrine carcinoma, a grade-matched control group of 40 invasive ductal carcinoma was formed. Prognostic features such as overall survival period and relapse – free survival period were also studied; but only for a limited follow – up period with an average of approximately 30 months. Usual negativity of estrogen and progesterone receptors in apocrine carcinoma was once more confirmed by this study. Results were consistent with related literature, indicating presence of poor significant difference between clinicopathologic features of apocrine carcinoma and the other invasive ductal carcinomas of breast.

Özet

nvaziv meme karsinomu bulunan toplam 2488 Türk hastanın taranması sonucunda, bunların %0.7’sinde apokrin farklılaşma gösteren karsinom olduğu saptanmıştır. Bu çalışmanın amacı, nadir görülen bu meme karsinomu tipinin klinikopatolojik özelliklerini, Türk popülasyonunda değerlendirmektir. Bildiğimiz kadarıyla, çalışmamız şimdiye kadar apokrin karsinomlu Türk hastalardan oluşan en geniş gruba sahiptir. Hasta yaşı, tümör çapı, lenf nodu metastazı, lenfatik – vasküler invazyon, immünohistokimyasal östrojen reseptörü, progesteron reseptörü, HER2 tablosu gibi parametrelere bakılıp özel olmayan tip invaziv meme karsinomu ile karşılaştırılmıştır. 20 apokrin karsinomun karşısındaki kontrol grubu, eş farklılaşma dereceli 40 invaziv duktal karsinomdan oluşturulmuştur. Toplam yaşam süresi ve nükssüz yaşam süresi gibi prognostik göstergeler de çalışılmış; ancak ortalama 30 aylık hasta takip süresi nedeniyle sınırlı kalmıştır. Apokrin karsinomun bilinen östrojen ve progesteron negatiflikleri, bu çalışmayla da bir kez daha teyit edilmiştir. İlgili literatür ile uyumlu bulunmuş olan sonuçlar, apokrin karsinom ile memenin diğer invaziv karsinomları arasında klinikopatolojik özellikler açısından zayıf bir anlamlı farklılık olduğunu göstermektedir.

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Cite This Article

KIYICI, H., GÜLER, G., ALTUNDAĞ, K. (2014). Apokrin Farklılaşma Gösteren Karsinomlar: Türk Hastalarda Özel Olmayan Tip İnvaziv Meme Karsinomu ile Klinikopatolojik Özelliklerinin Karşılaştırılması. Uluslararası Hematoloji-Onkoloji Dergisi, Cilt: 24 - Sayı: 2, 118–122. https://ajindex.com/articles/322908

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