Yinelemiş Yüksek Grade Gliomlarda Stereotaktik Radyoterapi Sonrası Sağkalım

Objective & Hypothesis:We aimed to report our stereotactic radiotherapy experience with Cyberknife (Accuray, Inc., Sunnyvale, CA, USA) for patients with recurrent high grade glial tumor.

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Key Findings & Data:Forty-two patients with histologically proven malign glioma (30 glioblastoma, 12 anaplastic astrocytoma) and also treated with previous conventional fractioned radiotherapy underwent stereotactic radiotherapy via Cyberknife for their recurrent tumor in Ankara Oncology Hospital between July 2009-and September 2012.

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Conclusion & Impact:Stereotactic radiotherapy is an effective treatment modality in patients with recurrent glial tumor.

🔬Design:Research Article

📍Scope:2009 Verileri

⚙️Variables:Domain Parameters

Abstract

We aimed to report our stereotactic radiotherapy experience with Cyberknife (Accuray, Inc., Sunnyvale, CA, USA) for patients with recurrent high grade glial tumor. Forty-two patients with histologically proven malign glioma (30 glioblastoma, 12 anaplastic astrocytoma) and also treated with previous conventional fractioned radiotherapy underwent stereotactic radiotherapy via Cyberknife for their recurrent tumor in Ankara Oncology Hospital between July 2009-and September 2012. The median follow up time was 30 months (range, 8-144 months) after diagnosis and 10 months (range, 1-38 months) from stereotactic radiotherapy (SRT). The median survival from SRT are 8 months for glioblastoma patients and 11 months for grade 3 malign glioma patients (p= 0.157). The median survival from SRT are 9 months and 11 months in patients given chemotherapy and not given, respectively (p= 0.436). The median survival from SRT are 10 months in patients reoperated and 9 months not reoperated ( p= 0.827). Stereotactic radiotherapy is an effective treatment modality in patients with recurrent glial tumor.

Özet

Yinelemiş yüksek gradlı glial tümörlü 42 hastada cyberknife deneyimimizi sunmaktayız. Ankara Onkoloji Hastanesinde, Temmuz 2009 ile Eylül 2012 tarihleri arasında yinelemiş 42 malign gliomlu (30 glioblastom, 12 anaplastik astrositom) hastaya Cyberknife (Accuray, Inc., Sunnyvale, CA, USA) ile stereotaktik radyoterapi uygulandı. Teşhisden sonraki ortanca takip zamanı 30 ay (aralık 8-144 ay), stereotaktik radyoterapi (SRT) sonrası ortanca takip zamanı 10 ay (aralık, 1-38 ay). Ortanca sağkalım, SRT sonrası glioblastom hastaları için 8 ay iken grade 3 gliomlu hastalar için 11 ay idi (p= 0.157). Stereotaktik radyoterapi sonrası ortanca sağkalım, kemoterapi alan hastalarda 9 ay iken almayanlarda 11 ay idi (p= 0.436). Nüks sonrası tekrar opere edilebilen hastalarda SRT sonrası ortanca sağkalım 10 ay iken opere edilemeyenlerde 9 ay bulundu( p= 0.827). Yinelemiş glial tümürlü hastaların tedavisinde stereotaktik radyoterapi etkin bir seçenektir.

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Cite This Article

ERTAŞ, G., UCER, A. R., GUNEY, Y. Y., AVCI, G. G., ALTUNDAG, M. B., ABANUZ, H., DEMIRKASIMOGLU, A., ÇALIKOĞLU, T. (2014). Yinelemiş Yüksek Grade Gliomlarda Stereotaktik Radyoterapi Sonrası Sağkalım. Uluslararası Hematoloji-Onkoloji Dergisi, Cilt: 24 - Sayı: 4, 233–238. https://ajindex.com/articles/322877

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