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Journals / Uluslararası Hematoloji-Onkoloji Dergisi / 2014 / Cilt: 24 - Sayı: 1

Meme Tümöründe Kalsifiye Edici Nanopartiküllerin Varlığına Dair Bir Ön İnceleme

A Preliminary Investigation on the Presence of Calcifying Nanoparticles in the Breast Tumor

Pınar BAYDIN OZKAL
Sedef J. GOCMEN
Esra ERDEMLİ
Ibrahim G. TUNC
Hasan B. SENER
Berrak GÜMÜŞKAYA
Asuman SUNGUROĞLU
Pages
17–22
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We could not find CNP in the breast tumor tissue, but we think this research will open a new field of study for researchers.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Calcium phosphate is deposited in many diseases, but the molecular basis of mineralization remains largely unknown.
📊
Key Findings & Data:With this aim, the presence of CNP was investigated by culturing 16 patients’ breast tumor tissue and from 2 pathologic tissues with transmission electron microscopy (TEM) and scanning electron microscopy (SEM).
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Conclusion & Impact:We could not find CNP in the breast tumor tissue, but we think this research will open a new field of study for researchers.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Calcium phosphate is deposited in many diseases, but the molecular basis of mineralization remains largely unknown. Biomineralizied calcifications that are formed by calcium deposits are also detected in breast mammograms. Some of the detected microcalcifications are thought to be related with malignancy. Taken together, calcifying nanoparticles (CNP) may be thought as a source of malign calcifications in breast cancers. The aim of the study is to research the presence of CNP in breast tumor tissue. With this aim, the presence of CNP was investigated by culturing 16 patients’ breast tumor tissue and from 2 pathologic tissues with transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Their growth was monitored by optical density (OD) at a wavelength of 650 nm. CNP couldn’t be found in the analysed tissues. The presence of CNP in the breast tumor tissue was researched for the first time. We could not find CNP in the breast tumor tissue, but we think this research will open a new field of study for researchers.

Özet

Kalsiyum fosfat depolanması pek çok hastalıkta görülür, fakat mineralizasyonun moleküler nedeni büyük oranda bilinmemektedir. Kalsiyum depolanmasıyla oluşan biyomineral kalsifikasyonlar mamogramla saptanmaktadır. Saptanan mikrokalsifikasyonların bazılarının maligniteyle ilişkili olabileceği düşünülmektedir. Tüm bu bilgiler göz önüne alındığında, kalsifiye edici nanopartiküller (CNP) malign kalsifikasyonların nedeni olarak düşünülebilir. Bu çalışmanın amacı, meme tümör dokusunda CNP varlığını araştırmaktır. Bu amaçla, CNP varlığı 16 hastanın meme tümör dokusunun kültürü sonrası ve 2 patolojik dokunun geçirimli ve taramalı elektron mikroskopları (TEM ve SEM) ile incelenmesi ve 650 nm’de optik densitenin ölçülmesi ile araştırılmıştır. Analiz edilen dokularda CNP saptanamamıştır. Bu çalışmayla, CNP varlığı ilk defa meme tümör dokusunda araştırılmıştır. Meme tümör dokusunda CNP bulunamamakla birlikte bu çalışmanın araştırmacılara yeni araştırma alanları açacağı düşünülmektedir.

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Cite This Article

OZKAL, P. B., GOCMEN, S. J., ERDEMLİ, E., TUNC, I. G., SENER, H. B., GÜMÜŞKAYA, B., SUNGUROĞLU, A. (2014). Meme Tümöründe Kalsifiye Edici Nanopartiküllerin Varlığına Dair Bir Ön İnceleme. Uluslararası Hematoloji-Onkoloji Dergisi, Cilt: 24 - Sayı: 1, 17–22. https://ajindex.com/articles/322867

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