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Journals / Uluslararası Hematoloji-Onkoloji Dergisi / 2016 / Cilt: 26 - Sayı: 3

Allojeneik Hematopoietik Kök Hücre Nakli Sonrasinda Fertilite: Üçüncü Basamak Hastanenin 23 Yıllık Veri Derlemesi

Fertility After Allogeneic Hematopoietic Stem Cell Transplantation: A 23-Year Review From A Tertiary Hospital

Pinar ATILLA ATACA
Erden ATILLA
Elif EDIBOGLU
Sinem C BOZDAG
Selami K. TOPRAK
ÖNDER ARSLAN
MUHİT ÖZCAN
Günhan GÜRMAN
PERVİN TOPÇUOĞLU
Pages
145–152
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

No relation was detected between the myeloablative conditioning regimen, radiotherapy prior to Allo-HSCT, TBI usage and frequency, and development of acute and chronic GVHD with infertility

📌 3 Key Takeaways

🎯
Objective & Hypothesis:ABSTARCAT Infertility is a major late side effect after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
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Key Findings & Data:We retrospectively evaluated the fertility of 107 adult patients who underwent Allo-HSCT (median age: 32.3) between 1989-2012 at our center and survived 2 years or more after transplantation.
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Conclusion & Impact:No relation was detected between the myeloablative conditioning regimen, radiotherapy prior to Allo-HSCT, TBI usage and frequency, and development of acute and chronic GVHD with infertility
🔬Design:Research Article
📍Scope:2012 Verileri
⚙️Variables:Domain Parameters

Abstract

ABSTARCAT Infertility is a major late side effect after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, healthy pregnan- cies and births were reported previously. We retrospectively evaluated the fertility of 107 adult patients who underwent Allo-HSCT (median age: 32.3) between 1989-2012 at our center and survived 2 years or more after transplantation. From totally 29 pregnancies (21 partners of male patients vs 8 female patients), 6 of the female patients (14%) and 20 of the male patients (45%), had a child after Allo-HSCT. The benign nature of the initial diagnosis, lack of chemotherapy regimen before transplantation, early age and no relapse of the primary disease contribute to fertility in our study. No relation was detected between the myeloablative conditioning regimen, radiotherapy prior to Allo-HSCT, TBI usage and frequency, and development of acute and chronic GVHD with infertility

Özet

Allojeneik Hematopoietik Kök Hücre Nakli Sonrasinda Fertilite: Üçüncü Basamak Hastanenin 23 Yıllık Veri DerlemesiAllojeneik kök hücre nakli (AKHN) sonrası en önemli uzun dönem yan etkilerden birisi infertilitedir. Fakat, daha önceki çalışmalarda sağlıklı gebelikler ve doğumlar bildirilmiştir. 1989-2012 yılları arasında merkezimizde AKHN yapılmış ve transplantasyon sonrası 2 yıl ve üzeri yaşayan 107 erişkin hasta (ortanca yaş: 32,3) retrospektif olarak değerlendirilmiştir. 29 gebelikten (21 erkek hastaların eşlerinden, 8 kadın hasta), 6 kadın hasta (%14) ve 20 erkek hastanın eşi (%45) AKHN sonrasında çocuk sahibi olmuştur. Tanı anında benign karakterde hastalık, transplantasyon öncesi kemoterapi almamış olmak, erken yaş, primer hastalığın nüksünün olmaması fertilite ile ilişkili olarak bulunmuştur. Myeloablatif hazırlık rejimi, AKHN öncesi radyoterapi, TBI kullanımı ve sıklığı, akut veya kronik graft versus host hastalığı fertilite ile ilişkili değildir

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Cite This Article

ATACA, P. A., ATILLA, E., EDIBOGLU, E., BOZDAG, S. C., TOPRAK, S. K., ARSLAN, Ö., ÖZCAN, M., GÜRMAN, G., TOPÇUOĞLU, P. (2016). Allojeneik Hematopoietik Kök Hücre Nakli Sonrasinda Fertilite: Üçüncü Basamak Hastanenin 23 Yıllık Veri Derlemesi. Uluslararası Hematoloji-Onkoloji Dergisi, Cilt: 26 - Sayı: 3, 145–152. https://ajindex.com/articles/322838

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