Journals / Uluslararası Hematoloji-Onkoloji Dergisi / 2017 / Cilt: 27 - Sayı: 4

Solit Organ Malignitesi Nedeniyle Kemoterapi Planlanan Kronik Hepatit B Enfeksiyonlu Hastalarin Takibi

Follow-up of Chronic HBV Infected Patients Planned Chemotherapy Due to Solid Organ Malignancy

Pages
213–219
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the moderate endemicity areas like Turkey for HBV infection, all patients must be screened for HBV before starting of chemotherapy

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of this study was to screen the patients with solid organ malignancy for HBV (Hepatitis B virus) infection before the start of chemotherapy and follow up in the oncology department of our setting.
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Key Findings & Data:All cases admitted to oncology department for chemotherapy were screened prospectively for HBV infection and reactivation between March 2013-September 2014.
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Conclusion & Impact:In the moderate endemicity areas like Turkey for HBV infection, all patients must be screened for HBV before starting of chemotherapy
🔬Design:Research Article
📍Scope:2013 Verileri
⚙️Variables:Domain Parameters

Abstract

The aim of this study was to screen the patients with solid organ malignancy for HBV (Hepatitis B virus) infection before the start of chemotherapy and follow up in the oncology department of our setting. All cases admitted to oncology department for chemotherapy were screened prospectively for HBV infection and reactivation between March 2013-September 2014. A total of 225 patients were included in the study and divided into 3 groups; Group I: having recovered past HBV infection: 43 patients (19.1%), Group II: isolated Anti-HBcAg total positive: 20 patients (8.9%) and Group III: chronic HBV infection with 10 patients (4.4%). HBV reactivation developed in one (5.9%) of 17 patients in group II, and two (28.6%) of seven patients in group III while under lamivudine prophylaxis. Neither hepatitis flare by HBV reactivation nor HBV-related death were observed in our study. In the moderate endemicity areas like Turkey for HBV infection, all patients must be screened for HBV before starting of chemotherapy

Özet

Bu çalışmada kurumumuzun onkoloji bölümünde solid organ malignitesi nedeniyle kemoterapi tedavisi planlanan hastaların HBV (Hepatit B Virüsü) enfeksiyonu açısından taranması ve takibi amaçlanmıştır. Mart 2013 - Eylül 2014 tarihleri arasında kemoterapi için onkoloji bölümüne başvuran tüm olgular, HBV için prospektif olarak taranmış ve reaktivasyon açısından takip edilmiştir. Çalışmaya 225 hasta dahil edilmiş ve üç gruba ayrılmıştır; Grup I: Geçirilmiş HBV enfeksiyonu: 43 hasta (19.1%), Grup II: İzole Anti-HBcAg total pozitif: 20 hasta (8.9%) ve Grup III: Kronik HBV enfeksiyonu : 10 hasta (4.4%). HBV reaktivasyonu grup II'de 17 hastanın birinde (5.9%) görülürken grup III'te yedi hastanın ikisinde lamivudin profilaksisi altında gelişmiştir. Çalışmamızda HBV reaktivasyonuna bağlı hepatit tablosu veya HBV'ye bağlı ölüm gözlenmemiştir. Türkiye gibi HBV enfeksiyonu açısından orta endemisite olan bölgelerde, kemoterapi tedavisi öncesi tüm hastalar HBV enfeksiyonu açısından taranmalıdır

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Cite This Article

MALİGNANCY, S. O., ERDEM, H. A., PULLUKÇU, H., TAŞBAKAN, M., SIPAHI, O. R., ULUSOY, S., SERTÖZ, Ş. R., USLU, R., YAMAZHAN, T. (2017). Solit Organ Malignitesi Nedeniyle Kemoterapi Planlanan Kronik Hepatit B Enfeksiyonlu Hastalarin Takibi. Uluslararası Hematoloji-Onkoloji Dergisi, Cilt: 27 - Sayı: 4, 213–219. https://ajindex.com/articles/322803

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