Journals / Selçuk Tıp Dergisi / 2002 / Cilt: 18 - Sayı: 2

The value of AgNOR's in differantiated preneoplastic and neoplastic endometrial lesions

Endometriumun preneoplastik ve neoplastik lezyonlarının ayırıcı tanısında AgNOR'un önemi

Pages
79–81
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results obtained indicate that AgNOR counts have statistical significant in differantiating between well differantiated endometrial adenocarcinoma and, simple hyperplasia and complex hyperplasia with and without atypia.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The aim of the study was carried out to investigate the diagnostic value of the AgNOR to distinguishing between preneoplastic and neoplastic lesions of the endometrium.
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Key Findings & Data:Retrospective analysis included tissue material obtained from 50 patients with simple and complex hyperplasia with and without atypia and well differantiated endometrial adenocarcinoma.
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Conclusion & Impact:The results obtained indicate that AgNOR counts have statistical significant in differantiating between well differantiated endometrial adenocarcinoma and, simple hyperplasia and complex hyperplasia with and without atypia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Endometriyum hiperplazisi · Endometriyum neoplazmları · Adenokarsinom

Abstract

The aim of the study was carried out to investigate the diagnostic value of the AgNOR to distinguishing between preneoplastic and neoplastic lesions of the endometrium. Retrospective analysis included tissue material obtained from 50 patients with simple and complex hyperplasia with and without atypia and well differantiated endometrial adenocarcinoma. Sections were stained with AgNOR technique. The results obtained indicate that AgNOR counts have statistical significant in differantiating between well differantiated endometrial adenocarcinoma and, simple hyperplasia and complex hyperplasia with and without atypia.

Özet

Endometriumun preneoplastik ve neoplastik lezyonlarının ayırıcı tanısında AgNOR sayılarının önemini araştırmak amacıyla, basit endometrial hiperplazi (n=10), atipili basit endometrial hiperplazi (n=10), atipisiz kompleks hiperplazi (n=10), atipili kompleks hiperplazi (n=10) ve iyi diferansiye endometrial adenokarsinom tanısı almış toplam 50 olgu AgNOR yöntemiyle boyandı. İyi diferansiye endometrial adenokarsinom ile karşılaştırıldığında atipili ve atipisiz basit hiperplazi ve kompleks hiperplazide görülen ortalama AgNOR sayıları arasında farklılık istatiksel olarak anlamlı bulundu (p<0.001).

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Cite This Article

ÖZERCAN, İ. H., ÇOBANOĞLU, B. (2002). The value of AgNOR's in differantiated preneoplastic and neoplastic endometrial lesions. Selçuk Tıp Dergisi, Cilt: 18 - Sayı: 2, 79–81. https://ajindex.com/articles/319369

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References (15)

  1. Alan Rand Schenned, MD. Nucleolar Organizer Regions as Discriminations for the Diagnosis of Well 1- Differantiated Adenocarcinoma of the Prostate. Arch Pathol Lab Med 1993; 117:1000-4
  2. Crocker J, Ayresd Me Goven J. Nucleolar Organizer Regions in Small Cell Carcinoma of the Bronchus. Thorax 1987; 42:972-5
  3. Crocker J, Boldly DAR, Ergan MJ. How Should We Count AgNORs Proposals for A Standartized Approach. J Pathol 1988; 158: 185-8
  4. Crocker J, Skillbeck N. Nucleolar Organizer Region Associated Proteins in Cutaneous Lesions. A Quantitative Study. J Clin Pathol 1987; 40: 885-9
  5. Derenzini M, Persion A, Farabegol F. Relationship Between Interphasic Nucleolar Organizer Regions and Growth Rate in Two Neuroblastoma Cell Lines. Am J Pathol 1989; 134:4: 925 32
  6. Deschenes J, Weidner N. Nucleolar Organizer Regions (NOR) in Hyperplastic and Neoplastic Prostate Disease. Am J Surg Pathol 1990; 14: 1148-55
  7. Egan MT, Raafat F, Crocker J, Nucleolar Organizer Regions in Fibrous Proliferations of Childhood and Infantile Fibrosarcoma. J Clin Pathol 1988; 41: 31-3
  8. Derenzini M, Ploton D. Interphase Nucleolar Organizer Regions in Cancer Cells. Int Rev Exp Pathol 1991; 32: 150-92
  9. Terlikowski S, Sulkowski S, Sulkowska M, Lenczewski A, Lotocki W. Differential Expression of AgNORs in Selected States of Endometrial Proliferation. Gin Pol 1996; 67: 141-5
  10. Trabucco S, Varcaccio-Garofalo G, Botticella MA, De- Stefano R, Capursi T, Resta L Expression of AgNORs in Serous Ovarian Tumors. Eur J Gynaecol Oncol 1994; 3:222-9
  11. Aaltoma S, Lipponen P, Syrjanen K. Nucleolar Organizer Regions Related to Morphometry, Flow Cytometry, Sex Steroid Receptor Content, Tumour Histology and Prognosis in Female Breast Cancer. Pathol Res Pract 1993; 4: 416-21
  12. Ohri AK, Ohri SK, Herbert A, Royle G, Taylor I. The Relationship Between Clinical Staging, Oestrogen Receptor Status and Silver Binding Nucleolar Organizer Regions (AgNOR) in Breast Carcinoma. Eur J Surg Oncol 1992; 2: 103-7
  13. Aubelc M, Auer G, Jutting U, Falkmar U, Gais P. Prognostic Value of Quantatively Measured AgNORs in Ductal Mammary Carcinoma. Anal Quant Cytol Histöl 1994; 3:211-8
  14. Criscuolo M, Martinelli AM, Migaldi M, Zunarelli E, Bergamaschi M, Falchi AM, et al. Prognotic Significance of Nucleolar Organizer Region in Ovarian Epithelial Tumors. Int J Gynecol Pathol 1993; 3:259-63
  15. Kenji Niwa, Yasuhiro Yokoyoma,Takuji Tanaka, Hidehiro Mori, Hideki Mori Teruhiko Tamaya. Silver Stained Nucleolar O