Journals / Selçuk Tıp Dergisi / 2005 / Cilt: 21 - Sayı: 2

Is atherosclerosis risk lower in CAPD patients?

Sürekli ayaktan periton diyalizi hastalarında ateroskleroz riski daha mı düşük?

Pages
55–58
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

CAPD may be more advantageous and defender for atherosclerosis with renal replacement therapy patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Atherosclerotic heart disease is the most causes of morbidity and mortality in chronic renal failure patients.
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Key Findings & Data:We compared CAPD and HD patients for cardiovasculer disease (CVD) risk factors and increased mean carotid artery intima media tickness (MClMTj that results early atherosclerosis.
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Conclusion & Impact:CAPD may be more advantageous and defender for atherosclerosis with renal replacement therapy patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Karotis arterleri · Risk faktörleri · Periton diyalizi

Abstract

Aim: Atherosclerotic heart disease is the most causes of morbidity and mortality in chronic renal failure patients. We compared CAPD and HD patients for cardiovasculer disease (CVD) risk factors and increased mean carotid artery intima media tickness (MClMTj that results early atherosclerosis. Method: 25 HD patients (I2M.13F, mean age 42.3 11.4 year, dialysis time 32.6 19.5 month) and 28 CAPD patients (10 M.I 8 F, mean age 41.8 9.5 year,dialysis time 25.5 22.1 month) in our clinic were included to the study. All patients bilateral carotid arteries examined by B mode ultrasonography and measured MCIMT. Patients with diabetes mellitus and more than 10 years undergo dialysis excluded. Results: I n HD patients homocystein level and MCIMT are higher when compaired with CAPD patients, (in order p=O.OI2 and p=0.011). But in CAPD patients plasma total cholesterol and triglycerid levels are higher than HD patients, (in order p=0.001 and p=0.008) There is a positive correlation between MCIMT and homocystein level in HD patients (p=0.001,r= 0.677) but not yet in CAPD patients. Conclusion: In CAPD patients MCIMT; early sign of atherosclerosis and homocystein level are lower. CAPD may be more advantageous and defender for atherosclerosis with renal replacement therapy patients.

Özet

Amaç: Aterosklerotik kalp hastalığı kronik böbrek yetmezliği (KBY) hastalarda morbidite ve mortalitenin başlıca nedenidir. Bu çalışmada erken dönem aterosklerozun bir bulgusu olarak yorumlanan artmış karotid arter intima media kalınlığı (İMK)ile çeşitli kardiyovasküler hastalık risk faktörlerinin sürekli ayaktan periton diyalizi (SAPD) ve hemodiyaliz (HD) hastalarında karşılaştırılması amaçlandı. Metod: Kliniğimizde takip edilen hastalardan rastgele örnekleme yöntemiyle seçilen 25 hemodiyaliz (I2E, 13 K; ortalama yaş 42. 3 ± 11.4 yıl, diyaliz süresi 32.6 f 19.5 ay) ve 28 periton diyaliz hastası (10 E 18 K; ortalama yaş 41. 8 ± 9.5 yıl, diyaliz süresi 25.5 ± 22.1 ay) çalışmaya dahil edildi. Diabetes mellitusu olan ve 10 yıldan uzun süreli diyalize giren hastalar çalışmaya dahil edilmedi. Tüm hastaların ekokardiografileri ve karotis arter incelemeleri, hastaların klinik ve laboratuar bilgileri belirtilmeden aynı kardiyolog tarafından yapıldı. Bulgular: SAPD hastalarıyla karşılaştırıldığında, HD hastalarında hem homosistein düzeyi hem de karotid arter-İMK anlamlı olarak arttığını saptadık (sırasıyla p=0.012 ve p=0.011). Buna karşın SAPD hastalarında total kolesterol ve trigliserid düzeyleri daha yüksek saptandı (sırasıyla p=0.000l ve p=0.008). HD hastalarında; İMK İle homosistein düzeyi arasında pozitif ilişki saptanırken (r=0.677, p=0.00l), SAPD hastalarında ise böyle bir İlişki tespit edilmedi. Sonuç: SAPD hastalarında hem erken dönem aterosklerozun bulgusu olan İMK hem de homosistein düzeyleri daha düşük olarak saptandı. SAPD tedavisi ateroskleroz gelişimi açısından daha avantajlı bir tedavi seçeneğe olabilir.

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Cite This Article

ALTINTEPE, L., DEMİR, M., TONBUL, H. Z., DÜZENLİ, M. A., GÜNEY, İ., TÜRK, S., YEKSAN, M. (2005). Is atherosclerosis risk lower in CAPD patients?. Selçuk Tıp Dergisi, Cilt: 21 - Sayı: 2, 55–58. https://ajindex.com/articles/319214

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