Journals / Selçuk Tıp Dergisi / 2021 / Cilt: 37 - Sayı: 1

The Relationship Between F-18 FDG PET/CT Parameters and Clinical Stage in Patients with Lung Cancer

Akciğer Kanserli Hastalarda F-18 FDG PET/BT Parametrelerinin Klinik Evre ile İlişkisi

Pages
24–31
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Higher SUVmax, SUVmean, MTV, and TLG values of the primary tumor were predicting the more advanced clinical stage in NSCLC.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: It was aimed to investigate the relationship of disease clinical stage between the maximum diameter of primer lesion (MDPL), maximum of standardized uptake value (SUVmax), mean of standardized uptake value (SUVmean), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values derived from positron emission tomography/computed tomography (PET/CT).
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Key Findings & Data:Patients and Methods: Lung cancer patients diagnosed histopathologically between 01.01.2012 and 31.12.2014 in Necmettin Erbakan University Nuclear Medicine Department of Meram Medical Faculty scanned for PET/CT for lung cancer diagnosis and staging, were included in this study.
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Conclusion & Impact:Conclusion: Higher SUVmax, SUVmean, MTV, and TLG values of the primary tumor were predicting the more advanced clinical stage in NSCLC.
🔬Design:Research Article
📍Scope:2012 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: It was aimed to investigate the relationship of disease clinical stage between the maximum diameter of primer lesion (MDPL), maximum of standardized uptake value (SUVmax), mean of standardized uptake value (SUVmean), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values derived from positron emission tomography/computed tomography (PET/CT). Patients and Methods: Lung cancer patients diagnosed histopathologically between 01.01.2012 and 31.12.2014 in Necmettin Erbakan University Nuclear Medicine Department of Meram Medical Faculty scanned for PET/CT for lung cancer diagnosis and staging, were included in this study. MDPL, SUVmax, SUVmean, TLG and MTV derived from PET-CT scanning and their histopathological subtypes, other clinical and radyological information of patients were noted. The non-small cell lung cancer (NSLC) were graded according to tumor diameter, nodal and involvement metastasis (TNM) staging system. The small cell lung carcinoma (SCLC) diagnosed were categorised as limite d or extensive stage. Results: In this study, the mean age of 118 men and 12 women, totally 130 patients, was evaluated 63,46 ±9,96. The patients were classified as 106 NSCLC (81.5%) ve 24 SCLC (18.5%). The histopathologically diagnosed NSCLC patients were consists of 62 squamous cell cancers, 39 adeno cancers, and 5 other subtypes. It was observed that there was no significant relationship between the MDPL, SUVmax, SUVmean, MTV and TLG values among SCLC. Additionally, it was also found that there was no correlation between these parameters with the SCLC stage. MDPL, SUVmax, SUVmean, MTV and TLG parameters were related with stage in NSCLC patients. Conclusion: Higher SUVmax, SUVmean, MTV, and TLG values of the primary tumor were predicting the more advanced clinical stage in NSCLC.

Özet

Amaç: Bu çalışmada akciğer kanserinin pozitron emisyon tomografi/bilgisayarlı tomografi (PET/BT)’den elde edilen primer lezyonun en geniş çapı (LEGÇ), maksimum standardize alım değeri (SUVmax), ortalama standardize alım değeri (SUVmean), metabolik tümör hacmi (MTV) ve toplam lezyon glikolizis (TLG) değerlerinin klinik evre ile ilişkisi incelenecektir . Hastalar ve Yöntem: Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi Nükleer Tıp Anabilim Dalında 01.01.2012- 31.12.2014 tarihleri arasında PET/BT görüntülemesi yapılan, akciğer kanseri tanılı hastalar çalışmaya alındı. PET/BT görüntülerinden elde edilen LEGÇ, SUVmax, SUVmean, MTV ve TLG değerleri ile histopatolojik alt tipler not edildi. Küçük hücre dışı akciğer kanseri (KHDAK) tanısı alan hastalar TNM (Tümör boyutu, lenf nodu, uzak metastaz) evreleme sistemi ile evrelendirildi. Küçük hücreli kanser (KHAK) tanısı alanlar sınırlı ya da yaygın evre olarak sınıflandırıldı . Bulgular: Yüz on sekizi erkek ve 12’si kadın toplam 130 hastanın, ortalama yaşı 63,46 ± 9,96 idi. Yüz altı hasta (%81,5) KHDAK iken; 24 (%18,5) hastaya KHAK idi. KHDAK hastaların 62’si yassı hücreli kanser, 39’u adenokanser, 5’i diğer alt tiplerden oluşmaktaydı. PET/BT görüntülerinden elde edilen LEGÇ, SUVmean, SUVmax’ın ortalama değerlerinin, MTV ile TLG’nin ortanca değerlerinin KHDAK ile KHAK hasta grupları arasında anlamlı fark yoktu. Ayrıca bu parametrelerin KHAK’de evre ile ilişkisinin olmadığı da bulundu. KHDAK’de LEGÇ, SUVmax, SUVmean, MTV ve TLG parametrelerinin klinik evre ile ilişkili olduğu saptandı. Sonuç: Küçük hücreli dışı akciğer kanserinde yüksek SUVmax, SUVmean, MTV ve TLG değerleri ileri klinik evreyi predikte etmektedir .

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Cite This Article

EROL, M., ÖNNER, H., TAŞTEKİN, G. (2021). The Relationship Between F-18 FDG PET/CT Parameters and Clinical Stage in Patients with Lung Cancer. Selçuk Tıp Dergisi, Cilt: 37 - Sayı: 1, 24–31. https://ajindex.com/articles/318992

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