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Journals / Solunum Hastalıkları / 2002 / Cilt: 13 - Sayı: 3

Evaluation of thorax high-resolution computed tomography and pulmonary function tests in patients with chronic hepatitis C virus infection

Kronik hepatit C infeksiyonlu hastalarda yüksek rezolüsyonlu bilgisayarlı toraks tomografisi ve solunum fonksiyon testlerinin değerlendirilmesi

Oğuzhan OKUTAN
Zafer KARTALOĞLU
Ahmet İLVAN
Ali KUTLU
Erkan BOZKANAT
Emir ŞİLİT
Pages
190–196
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a conclusion, we suggest that chronic hepatitis C infection may cause pulmonary interstitial involvement without evident respiratory symptoms.

📌 3 Key Takeaways

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Objective & Hypothesis:in this study, we aimed that pulmonary involvement investigated via pulmonary function tests (PFTs) and high-resolution computed tomography (HRCT) in patients with chronic hepatitis C infection (HCV).
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Key Findings & Data:Thirty-four patients with chronic HCV infection without diagnosis of any lung disease and 10 healthy cases enrolled to the study.
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Conclusion & Impact:As a conclusion, we suggest that chronic hepatitis C infection may cause pulmonary interstitial involvement without evident respiratory symptoms.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hepatit C · Solunum fonksiyon testleri · Spirometri

Abstract

in this study, we aimed that pulmonary involvement investigated via pulmonary function tests (PFTs) and high-resolution computed tomography (HRCT) in patients with chronic hepatitis C infection (HCV). Thirty-four patients with chronic HCV infection without diagnosis of any lung disease and 10 healthy cases enrolled to the study. It was performed PFT and HRCT in all cases. And we investigated correlation between pulmonary involvement and liver pathology in patients with chronic HCV infection. On spirometric measurements, a reduction lower than 80% of the predicted value in vital capacity (VC) in 9 of the patients, in forced expiratory volume in one second (FEV1) in 8 patients, in forced expiratory flow 25-75 (FEF25-75) in 15 patients was detected. Carbon monoxide diffusing capacity (DLCO) was found reduced in 26 patients (76.5%). There was no significant difference between controls and patients with HCV infection in PFTs. Findings of interstitial pulmonary involvement were detected in the HRCT of 16 patients. It was detected that significant difference between control and patients with HCV infection in findings of HRCT (chi-square= 4.7, p= 0.03). Knodell histological activity index (KHAI) of 28 patients on whom liver biopsy were applied was 9.0 ± 4.7 (2-16). HRCT findings, spirometric values and DLCO were not affected by KHAI in patients with HCV infection. In these patients, all the parameters were observed to be related with age. As a conclusion, we suggest that chronic hepatitis C infection may cause pulmonary interstitial involvement without evident respiratory symptoms.

Özet

Bu çalışmada, kronik hepatit C virüs (HCV) infeksiyonlu hastalarda akciğer tutulumunu solunum fonksiyon testleri (SFT) ve yüksek rezolüsyonlu bilgisayarlı tomografi (YRBT) ile araştırmayı amaçladık. Herhangi bir akciğer hastalığı tanısı almamış 34 HCV infeksiyonlu hasta ile 10 sağlıklı kontrol olgusu çalışmaya alındı. Tüm olguların YRBT'leri çekildi ve SFT'leri yapıldı. Kronik HCV infeksiyonlu olgularda karaciğer patolojisi ile akciğer tutulumu arasındaki ilişkiler de araştırıldı. Spirometrik ölçümler sonunda, hastaların 9'unda vital kapasite (VC), 8'inde zorlu vital kapasite (FVC), 5'inde birinci saniye zorlu ekspiratuvar hacim (FEV1) 15'inde ise zorlu ekspirasyon ortası akım hızında (FEF25-75) beklenen değerin %80' inden fazla düşüş saptandı. Yirmialtı hastada (%76.5) karbonmonoksit difüzyon kapasitesi (DLCO) düşük bulundu. Kontrol grubu ile HCV infeksiyonlu olguların SFT'leri arasında anlamlı fark yoktu. Onaltı HCV infeksiyonlu olgunun YRBT'sinde interstisyel akciğer tutulumu ile uyumlu bulgular saptandı. Kontrol grubunda 1 olguda YRBT'de interstisyel patoloji vardı. YRBT bulguları açısından kontrol grubu ile HCV infeksiyonlu olgular arasında anlamlı fark bulundu (Ki-kare= 4.7 p= 0.03). Karaciğer biyopsisi yapılmış olan 28 hastanın Knodell histolojik aktivite indeksleri (KHAl) ortalama 9.0 ± 4.7 (2-16) idi. Kronik HCV'Iİ olgularda, YRBT bulguları, spirometrik ölçümler ve DLCO, KHAl ile ilişkisiz bulundu. Sadece DLCO'nun alveoler ventilasyona oranının (DLCO/VA) KHAİ ile ilişkili olduğu saptandı. İncelenen tüm parametrelerin HCV infeksiyonlu olgularda yaş ile ilişkili olduğu gözlendi. Sonuç olarak, kronik HCV infeksiyonunun belirgin solunumsal yakınmalar olmaksızın interstisyel akciğer tutulumuna yol açabileceğini düşünmekteyiz.

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Cite This Article

OKUTAN, O., KARTALOĞLU, Z., İLVAN, A., KUTLU, A., BOZKANAT, E., ŞİLİT, E. (2002). Evaluation of thorax high-resolution computed tomography and pulmonary function tests in patients with chronic hepatitis C virus infection. Solunum Hastalıkları, Cilt: 13 - Sayı: 3, 190–196. https://ajindex.com/articles/318634

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References (17)

  1. Alter MJ. Epidemiology of hepatitis C in the west. Semin Liver Dis 1995;15:5-14
  2. Hoofnagle JH. Hepatitis C: The clinical spectrum of disease. Hepatology 1997;26(Suppl 1):15-20
  3. Ferri C, Monti M, La Civita L et al. Infection of peripheral blood mononuclear cells by hepatitis C virus in mixed cryoglobunemia. Blood 1993;82:3701-4
  4. Pawlotsky JM, Roudot-Thoraval F, Simmonds P et al. Extrahepatic immunologic manifestations in chronic hepatitis C and hepatitis C virus serotypes. Ann Intern Med 1995;122:169-73
  5. Zignego AL, Ferri C, Monti M et al. Hepatitis C virus as a lymphotropic agent: Evidences and pathogenic implications. Clin Exp Rheumatol 1995;13(Suppl 13):33-7
  6. Ferri C, La Civita L, Fazzi P et al. Interstitial lung fibrosis and rheumatic disorders in patients with hepatitis C virus infection. Br J Rheum 1997;36:360-5
  7. Weidensaul D, Imam T, Holyst MM et al. Polymyositis, pulmonary fibrosis and hepatitis C virus. Arthritis Rheum 1995;38:437-9
  8. Hubbard R, Lewis S, Richards K et al. Occupational exposure to metal or wood dust and aetiology of cryptogenic fibrosing alveolitis. Lancet 1996;347:284-9
  9. Scott J, Johnston I, Britton J. What causes cryptogenic fibrosing alveolitis ? A case control study of environmental exposure to dust. BMJ 1990;301:1015-7
  10. Egan JJ, Woodcook AA, Stewart JP. Viruses and idiopathic pulmonary fibrosis. Eur Respir J 1997;10:1433-7
  11. Ueda T, Ohta K, Suzuki N et al. Idiopathic pulmonary fibrosis and high prevalance of serum antibodies to hepatitis C virus. Am Rev Respir Dis 1992;146:266-8
  12. Vergnon JM, Vincent M, de The G, et al. Crytogenic fibrosing alveolitis and Epstain-Barr virus: An association. Lancet 1984;2:768-71
  13. Kuwano K, Nomoto Y, Kunitake R et al. Detection of adenovirus EIA DNA in pulmonary fibrosis using nested polymerase chain reaction. Eur Respir J 1997;10:1145-9
  14. American Thoracic Society: Single breath carbon monoxide diffusion capacity (Transfer Factor): Recommendation for a standard technique. Am J Respir Dis 1987;136:1299-307
  15. Remy-Jardin MR, Giraud F, Remy J et al. Pulmonary sarcoidosis: Role of CT in the evaluation of disease activity and functional impairment and in prognosis assessment. Radiology 1994;191:675-80
  16. Knodell RG, Ishak KG, Black WC et al. Formulation and application of numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981;1:431-5
  17. Irving WL, Day S, Johnston ID. Idiopathic pulmonary