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Journals / Solunum Hastalıkları / 2004 / Cilt: 15 - Sayı: 2

Serology of Chlamydia pneumoniae in relation to atopy and pulmonary function tests in patients with stable asthma

Stabil astımlı olgularda Chlamydia pneumoniae seroprevalansının atopi ve solunum fonksiyonlarıyla ilişkisi

Zeliha Senem ELİBOL
FİGEN KADAKAL
Cemal BES
Mehmet Akif ÖZGÜL
Banu KÜÇÜK
Mustafa ASLAN
Veysel YILMAZ
Pages
69–75
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a conclusion, there was a relation between chronic stabile asthma and IgA, IgM antibodies reactive to C. pneumoniae while there was not between reactive antibodies and atopy and pulmonary function tests.

📌 3 Key Takeaways

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Objective & Hypothesis:We aimed to investigate the seroprevalence of Chlamydia pneumoniae, the association between serological evidence and atopy and pulmonary function tests in chronic stable asthmatic patients.
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Key Findings & Data:We analysed 40 patients with chronic stabile asthma individuals and 30 healthy individuals as control.
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Conclusion & Impact:As a conclusion, there was a relation between chronic stabile asthma and IgA, IgM antibodies reactive to C. pneumoniae while there was not between reactive antibodies and atopy and pulmonary function tests.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:İmmünglobulin G · Astım · Chlamydophila pneumoniae

Abstract

We aimed to investigate the seroprevalence of Chlamydia pneumoniae, the association between serological evidence and atopy and pulmonary function tests in chronic stable asthmatic patients. We analysed 40 patients with chronic stabile asthma individuals and 30 healthy individuals as control. Pulmonary function tests and skin prick tests were carried out in all subjects. C. pneumoniae specific IgG, IgM and IgA in serum were measured by using microimmunofluorescence (MIF) method. Chlamydia specific IgG seropositivity was 55% and 63.3% in patients with chronic stabile asthmatic and healthy individuals respectively (p> 0.05). Specific IgA was found to be 62.5% in asthma patients while it was 16.7% in control group (p< 0.001). Specific IgM antibodies reactive with C. pneumoniae was 15% in patients with stabile asthma while there was no specific IgM in control subjects (p< 0.05). When the patients were analysed as atopic and nonatopic subgroups, no relations were found between pulmonary function tests and presence of specific IgG, IgM and IgA seropositivity. As a conclusion, there was a relation between chronic stabile asthma and IgA, IgM antibodies reactive to C. pneumoniae while there was not between reactive antibodies and atopy and pulmonary function tests.

Özet

Bu çalışmada, kronik stabil astımlı olgularda Chlamydia pneumoniae'nm seroprevalansı, serolojik bulguların atopi ve solunum fonksiyon testleri ile olan ilişkisi araştırılmıştır. Çalışmaya 40 kronik stabil astımlı ile 30 sağlıklı erişkin alındı. Olgulara solunum fonksiyon testleri ve prick deri testleri yapıldı. Serumda mikroimmünfloresan (MIF) yöntemi ile C. pneumoniae IgG, IgM, IgA antikorları araştırıldı. Kronik stabil astımlılarda IgG seropozitifliği %55, sağlıklı erişkinlerde %63.3 olarak bulundu (p> 0.05). IgA seropozitifliği kronik stabil astımlılarda %62.5, sağlıklı erişkinlerde %16.7 olarak saptandı (p< 0.001). IgM pozitifliği ise, astımlılarda %15 iken, kontrol grubunun tümünde negatif bulundu (p< 0.05). Olgular atopik ve nonatopik olarak değerlendirildiğinde IgG, IgM, IgA seropozitifliği açısından gruplar arasında anlamlı fark bulunmadı. IgG, IgM, IgA seropozitifliği ile olguların solunum fonksiyon değerleri arasında istatistiksel olarak anlamlı fark saptanmadı. Sonuç olarak; kronik stabil astım ile C pneumoniae IgA, IgM seropozitifliği arasında anlamlı derecede ilişki saptanırken, atopik durumun ve solunum fonksiyon değerlerinin antikor pozitiflikleri ile ilişkisi bulunamadı.

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Cite This Article

ELİBOL, Z. S., KADAKAL, F., BES, C., ÖZGÜL, M. A., KÜÇÜK, B., ASLAN, M., YILMAZ, V. (2004). Serology of Chlamydia pneumoniae in relation to atopy and pulmonary function tests in patients with stable asthma. Solunum Hastalıkları, Cilt: 15 - Sayı: 2, 69–75. https://ajindex.com/articles/318569

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