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Journals / Southern Clinics of Istanbul Eurasia / 2019 / Cilt: 30 - Sayı: 2

Sarkoidozda Görülen Lenfopeni Hastalık Aktivitesi İle İlişkilimidir?

Is Lymphopenia Detected in Sarcoidosis Associated with the Disease Activity?

Coşkun DOĞAN
Sevda ŞENER CÖMERT
Benan ÇAĞLAYAN
Elif TORUN PARMAKSIZ
Nesrin KIRAL
Recep DEMİRHAN
Ali FİDAN
Seda Beyhan SAĞMEN
Pages
151–157
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Lenfopenik sarkoidoz olgularında düşük DLCO değerleri görülebilir.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Amaç: Bu çalışmada sarkoidoz olgularında tespit edilen lenfopenin hastalık aktivitesi ile ilişkisi incelenmiştir.
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Key Findings & Data:Gereç ve Yöntem: Çalışmaya Temmuz 2016–Haziran 2017 tarihleri arasında sarkoidoz tanısı alan olgular ve aynı dönem aktif hastalığı olmayan sağlıklı gönüllüler/aktif hastalık tanısı almayan olgular dahil edildi.
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Conclusion & Impact:Lenfopenik sarkoidoz olgularında düşük DLCO değerleri görülebilir.
🔬Design:Experimental Field Trial
📍Scope:2016 Verileri
⚙️Variables:Domain Parameters

Abstract

Amaç: Bu çalışmada sarkoidoz olgularında tespit edilen lenfopenin hastalık aktivitesi ile ilişkisi incelenmiştir. Gereç ve Yöntem: Çalışmaya Temmuz 2016–Haziran 2017 tarihleri arasında sarkoidoz tanısı alan olgular ve aynı dönem aktif hastalığı olmayan sağlıklı gönüllüler/aktif hastalık tanısı almayan olgular dahil edildi. Olguların tam kan sayımlarında mutlak lenfosit sayısı (MLS) %80 olan olguların 2±0.7’di (p=0.016). MLS ile %DLCO arasında pozitif yönde korelasyon tespit edildi (p=0.044, r=0.230). DLCO %80 olan olguların %15’inde lenfopeni vardı (p=0.01). Olguların sarkoidoz evreleri, semptomları ve radyolojik bulgular ile MLS arasında anlamlı ilişki tespit edilemedi (p>0.05). Sonuç: Sarkoidoz olgularında lenfopeni sık görülür. Lenfopenik sarkoidoz olgularında düşük DLCO değerleri görülebilir.

Özet

Objective: The association of lymphopenia detected in patients with sarcoidosis with disease activity was investigated in the present study. Methods: Patients who were diagnosed as having sarcoidosis and healthy volunteers/individuals with no diagnosis of active disease between July 2016 and June 2017 were included in this study. Patients who were detected to have an absolute lymphocyte count (ALC) of 80% was 2±0.7 (p=0.016). A positive correlation was detected between ALC and DLCO% (p=0.044, r=0.230). Although lymphopenia was detected in 42% of patients whose DLCO value was 80% (p=0.01). No significant association was detected among the sarcoidosis stage, symptom, and radiologic findings of the patients with the absolute lymphocyte count (p>0.05). Conclusion: Lymphopenia is frequently detected in patients with sarcoidosis. Lower DLCO values may be detected in patients with lymphopenic sarcoidosis.

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Cite This Article

DOĞAN, C., CÖMERT, S. Ş., ÇAĞLAYAN, B., PARMAKSIZ, E. T., KIRAL, N., DEMİRHAN, R., FİDAN, A., SAĞMEN, S. B. (2019). Sarkoidozda Görülen Lenfopeni Hastalık Aktivitesi İle İlişkilimidir?. Southern Clinics of Istanbul Eurasia, Cilt: 30 - Sayı: 2, 151–157. https://ajindex.com/articles/314017

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