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Journals / Southern Clinics of Istanbul Eurasia / 2021 / Cilt: 32 - Sayı: 1

Persimmon (Diospyros Kaki L.) Alleviates Ethanol-Induced Gastric Ulcer in Rats

Mustafa CAN GÜLER
Ayhan TANYELİ
ERSEN ERASLAN
Mehmet Ramazan BOZHÜYÜK
Fazile Nur EKİNCİ AKDEMİR
Erdem TOKAY
Nezahat KURT
Esra ÇAPANOĞLU GÜVEN
Gülay ÖZKAN
Pages
1–7
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Persimmon fruit extract demonstrated a gastroprotective effect in an ethanol- based gastric ulcer model in rats.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The worldwide incidence of a gastric ulcer is high, most often as a result of use of nonsteroidal anti-inflammatory drugs, excessive alcohol consumption, or Helicobacter pylori infection.
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Key Findings & Data:Methods: Two dosages of persimmon extract were applied in a gastric ulcer model created with 5 mL/kg ethanol in Wistar albino rats.
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Conclusion & Impact:Conclusion: Persimmon fruit extract demonstrated a gastroprotective effect in an ethanol- based gastric ulcer model in rats.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objective: The worldwide incidence of a gastric ulcer is high, most often as a result of use of nonsteroidal anti-inflammatory drugs, excessive alcohol consumption, or Helicobacter pylori infection. An ethanol-based gastric ulcer model in rats was used to examine the effect of persimmon (Diospyros kaki L.) extract as a potential form of treatment. Methods: Two dosages of persimmon extract were applied in a gastric ulcer model created with 5 mL/kg ethanol in Wistar albino rats. Histopathological and biochemical methods were used to assess any gastroprotective effects. Results: Persimmon extract significantly decreased the level of the cytokines interleukin (IL)-10, IL-6, tumor necrosis factor alpha (TNF-α) and IL-1 beta. Caspase-3 and nuclear factor kappa B expression was also significantly reduced. Conclusion: Persimmon fruit extract demonstrated a gastroprotective effect in an ethanol- based gastric ulcer model in rats.

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Cite This Article

GÜLER, M. C., TANYELİ, A., ERASLAN, E., BOZHÜYÜK, M. R., AKDEMİR, F. N. E., TOKAY, E., KURT, N., GÜVEN, E. Ç., ÖZKAN, G. (2021). Persimmon (Diospyros Kaki L.) Alleviates Ethanol-Induced Gastric Ulcer in Rats. Southern Clinics of Istanbul Eurasia, Cilt: 32 - Sayı: 1, 1–7. https://ajindex.com/articles/313948

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