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Journals / Southern Clinics of Istanbul Eurasia / 2017 / Cilt: 28 - Sayı: 2

The Effects of Steroid Therapy on Bone and Eyes in Children with Nephrotic Syndrome

Serap Genç YÜZÜAK
Bülent ATAŞ
Pages
5692–2
DOI
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⚡ TL;DR(Too Long; Didn't Read)

There was no statistically significant difference determined in terms of side effects of steroid treatment.Conclusion: Pediatricians should be very careful while following up the children who use steroids at a young age due to the possibility of cataract development and side effects on bone metabolism

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to evaluate complications of long-term steroid usage on the eyes and bone metabolism, which can be detected at early stage, and to encourage the necessary precautions.Methods: This retrospective study was performed with data of patients who took steroid therapy for nephrotic syndrome and were followed up between June 2006-May 2011 at Necmettin Erbakan University.
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Key Findings & Data:The mean age of the patients was 4.2±2.3 years.
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Conclusion & Impact:There was no statistically significant difference determined in terms of side effects of steroid treatment.Conclusion: Pediatricians should be very careful while following up the children who use steroids at a young age due to the possibility of cataract development and side effects on bone metabolism
🔬Design:Research Article
📍Scope:2006 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to evaluate complications of long-term steroid usage on the eyes and bone metabolism, which can be detected at early stage, and to encourage the necessary precautions.Methods: This retrospective study was performed with data of patients who took steroid therapy for nephrotic syndrome and were followed up between June 2006-May 2011 at Necmettin Erbakan University. Results: Fifty-six patients were included in this study. The mean age of the patients was 4.2±2.3 years. The patients were examined in 3 groups according to steroid therapy. Group 1 was defined as patients who had not received steroids in the past year and who were in the remission stage, Group 2 comprised patients who had received steroids in the last year and who were in the remission stage, and Group 3 was made up of patients who were in the active nephrotic period and had received steroids. In terms of biochemical parameters (serum urea, creatinine, calcium, phosphorus, magnesium, alkaline phosphatase, parathyroid hormone, osteocalcin, vitamin D, triglycerides), there was no statistically significant difference between the 3 groups. Group 3 had a higher ratio of calcium/creatinine and protein/creatinine in spot urine than Groups 1 and 2. Of 56 patients, 40 patients had eye examinations. There was no statistically significant difference determined in terms of side effects of steroid treatment.Conclusion: Pediatricians should be very careful while following up the children who use steroids at a young age due to the possibility of cataract development and side effects on bone metabolism

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Cite This Article

YÜZÜAK, S. G., ATAŞ, B. (2017). The Effects of Steroid Therapy on Bone and Eyes in Children with Nephrotic Syndrome. Southern Clinics of Istanbul Eurasia, Cilt: 28 - Sayı: 2, 5692–2. https://ajindex.com/articles/313626

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References (17)

  1. Safaei AA, Maleknejad S. Clinical and laboratory findings and therapeutic responses in children with nephrotic syndrome. Indian J Nephrol 2010;20:68–71
  2. Holmberg C, Tryggvason K, Kestila MK, Jalanko HJ. Glomerular disease. In: Avner E, editor. Pediatric Nephrology. New York: Lippincott Williams and Wilkins; 2004. p. 501–664
  3. Eddy AA, Symons JM. Nephrotic syndrome in childhood. Lancet 2003;362:629–39
  4. Niaudet P. Etiology, clinical manifestations, and diagnosis of nephrotic syndrome in children. Available at: http://www.uptodate.com/ contents/etiology-clinical-manifestations-and-diagnosis-of-nephrotic-syndrome-in-children. Accessed Sep 5, 2017
  5. Hodson EM, Alexander SI. Evaluation and management of steroidsensitive nephrotic syndrome. Curr Opin Pediatr 2008;20:145–50
  6. Abeyagunawardena AS, Dillon MJ, Rees L, van’t Hoff W, Trompeter RS. The use of steroid-sparing agents in steroid-sensitive nephrotic syndrome. Pediatr Nephrol 2003;18:919–24
  7. Gökkaya NKO, Kutsal YG. İlaca bağlı osteoporoz. Türk Osteoporoz Dergisi 2011;17:30–6
  8. Adler RA, Curtis JR, Saag K, Weinstein RS. Glucocorticoid-induced osteoporosis. In: Marcus R, Feldman D, Nelson DA, Rosen CJ, editors. Osteoporosis. 3rd ed. San Diego, CA: Elsevier-Academic Press; 2008. p. 1135–66
  9. Hız Ö, Karaaslan G, Yazmalar L, Tekeoğlu İ. Uzun Dönem Glukokortikoid Kullanımına Bağlı Gelişen Manifest Osteoporoz ve Sağ Femur Başı Avasküler Nekroz Birlikteliği: Olgu Sunumu. Van Tıp Dergisi 2008;15:90–4
  10. Saag KG, Furst DE. Major side effects of systemic glucocorticoids. Available at: http://www.uptodate.com/contents/major-side-effectsof-systemic-glucocorticoids. Accessed Sep 5, 2017
  11. De Nijs E, Brabant P, De Laey JJ. The adverse effects of corticosteroids in central serous chorioretinopathy. Bull Soc Belge Ophtalmol 2003:35–41
  12. Campos LM, Liphaus BL, Silva CA, Pereira RM. Osteoporosis in childhood and adolescence. J Pediatr (Rio J) 2003;79:481–8
  13. Niaudet P. Complications of nephrotic syndrome in children. Available at: http://www.uptodate.com/contents/complications-of-nephrotic-syndrome-in-children. Accessed Sep 5, 2017
  14. Pranić-Kragić A, Radić M, Martinović-Kaliterna D, Radić J. Glucocorticoid induced osteoporosis. Acta Clin Croat 2011;50:563–6
  15. Tanrıverdi Yüksel D, Ertan Ü, Baş AY, Yüksek M. Çocukluk çağı hastalıklarında oral prednizolon tedavisi ile oluşan yan etkiler. Fiziksel Tıp 2001;4:91–7
  16. Hachet E. Cataracts. Bull Soc Ophtalmol Fr 1985:87–107
  17. Biyikli NK, E