Journals / Su Ürünleri Dergisi / 2013 / Cilt: 30 - Sayı: 3

The effects of dioctyl adipate (DOA) on liver and gill histology of Sparus aurata ( Sea bream)

Dioktil adipat (DOA) 'ın Sparus aurata (Çipura) karaciğer ve solungaç histolojisi üzerine etkileri

Pages
115–122
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Consequently, it was emphasized that DOA needs to be taken into more consideration as being an aquatic ecotoxicant.

📌 3 Key Takeaways

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Objective & Hypothesis:Although it is used widely as a second plasticizer in the polymer manufacturing process, the ecotoxicological effects of dioctyl adipate (DOA) was not investigated in detail.
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Key Findings & Data:The aim of this research was to determine the histopathological changes in the gills and liver of male sea bream, Sparus aurata exposed to 250, 500 and 750 ppm DOA for 15 days, with light microscopy.
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Conclusion & Impact:Consequently, it was emphasized that DOA needs to be taken into more consideration as being an aquatic ecotoxicant.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Although it is used widely as a second plasticizer in the polymer manufacturing process, the ecotoxicological effects of dioctyl adipate (DOA) was not investigated in detail. The aim of this research was to determine the histopathological changes in the gills and liver of male sea bream, Sparus aurata exposed to 250, 500 and 750 ppm DOA for 15 days, with light microscopy. When compared with control, remarkable histopathological changes as vacuolation, dilatation of the central vein, and a striking fusion were observed in the gills of experimental fish. It was also noted hypertrophy and hyperplasia in the epithelial, pillar, mucoid and mitochondria-rich cells of the gills. The examining of livers from DOA-exposed specimens revealed a series of hepatocellular changes, including steatosis, necrosis and fibrosis. In addition to haemorrage, the parenchimatic sinusoids and the central veins of hepatopancreas were widened. The study demonstrated that the exposure to DOA results in multiple histological changes in both of the tissue investigated; moreover, all of the changes were associated with increasing concentration of the chemical that exposed. Consequently, it was emphasized that DOA needs to be taken into more consideration as being an aquatic ecotoxicant.

Özet

Polimer üretim süreçlerinde ikincil plastikleştirici olarak çok yaygın kullanılan dioktil adipat (DOA) ’ın ekotoksikolojik etkileri ayrıntılı olarak araştırılmamıştır. Bu çalışmanın amacı 15 gün süreyle 250, 500 ve 750 ppm DOA’ya maruz bırakılan erkek çipura balıklarının (Sparus aurata) solungaç ve karaciğerlerindeki histopatolojik değişimlerin ışık mikroskobu ile belirlenmesidir. Kontrol grubuyla karşılaştırıldığında, deneme grubu örneklerinin solungaçlarında vakuolizasyon, merkezi venada genişleme ve çarpıcı füzyon olarak ayırt edilen önemli histopatolojik değişimler gözlenmiştir. Ayrıca solungacın epitel, pillar mukus ve mitokondri zengini hücrelerinde belirgin hipertrofi ve hiperplazi de not edilmiştir. DOA’ya maruz bırakılan balıkların karaciğerlerinin incelenmesi yağlanma, fibrozis ve nekrozis olarak bir dizi hepatosellüler değişim ortaya koymuştur. Kanamaya ek olarak parankimatik sinüzoidler ve hepatopankreasın merkezi venleri genişlemiştir. Çalışma, DOA etkisinin araştırılan her iki dokuda da çoklu histolojik değişimlere yol açtığını, üstelik bu değişimlerin hepsinin uygulanan kimyasalın artan konsantrasyonuyla bağlantılı olduğunu göstermektedir. Sonuçta DOA’nın bir sucul kirletici olarak daha fazla dikkate alınması gerektiği vurgulanmıştır.

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Cite This Article

ÜRETEN, M., ÜÇÜNCÜ, S. İ. (2013). The effects of dioctyl adipate (DOA) on liver and gill histology of Sparus aurata ( Sea bream). Su Ürünleri Dergisi, Cilt: 30 - Sayı: 3, 115–122. https://ajindex.com/articles/311288

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