Journals / Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi / 2019 / Cilt: 23 - Sayı: 0

Synthesis of Some New Isatin Derivatives and Identification of Their Structures

Bazı Yeni İsatin Türevlerinin Sentezi ve Yapılarının Aydınlatılması

Pages
67–70
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The structure of the synthesized compounds, were elucidated by spectroscopic methods using IR, 1H-NMR, 13C-NMR spectra and Mass analysis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Indole, which has an important role in heterocyclic ring systems, exhibits significant biological effects.
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Key Findings & Data:Isatin (1H-indole-2,3-dione) has been used as a reagent in a large number of synthesis due to its biological properties.
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Conclusion & Impact:The structure of the synthesized compounds, were elucidated by spectroscopic methods using IR, 1H-NMR, 13C-NMR spectra and Mass analysis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:İsatin · İndol · Schiff bazı

Abstract

Indole, which has an important role in heterocyclic ring systems, exhibits significant biological effects. Isatin (1H-indole-2,3-dione) has been used as a reagent in a large number of synthesis due to its biological properties. In addition, it is a heterocyclic ring system used for obtaining and other reactions of indole and quinoline derivatives. In this study, two new Schiff base compounds were synthesized by the reaction of 2-aminoantracene with an isatin/5-nitro-isatin. The structure of the synthesized compounds, were elucidated by spectroscopic methods using IR, 1H-NMR, 13C-NMR spectra and Mass analysis.

Özet

Heterosiklik halka sistemlerinde önemli bir rolü olan indol, önemli biyolojik etkiler göstermektedir. Isatin (1H-indol-2,3-dion), biyolojik özellikleri nedeniyle çok sayıda sentezde bir reaktif olarak kullanılmıştır. Ayrıca, isatin, indol ve kinolin türevlerinin eldesinde ve reaksiyonlarında kullanılan, bir heterosiklik halka sistemidir. Bu çalışmada, iki yeni Schiff bazı bileşikleri, 2-aminoantrasen ile isatin/5-nitro-isatinin reaksiyonuyla sentezlendi. Sentezlenen bileşiklerin yapısı, IR, 1H-NMR, 13C-NMR spektrumları ve Kütle analizi kullanılarak spektroskopik yöntemlerle aydınlatıldı.

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Cite This Article

DOĞAN, İ. S., BÖLEK, G. G., KAHVECİ, B. (2019). Synthesis of Some New Isatin Derivatives and Identification of Their Structures. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Cilt: 23 - Sayı: 0, 67–70. https://ajindex.com/articles/310460

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References (13)

  1. Pandeya, S.N., Smitha, S., Jyoti, M., Sridhar, S.K. 2005. Biological Activities of Isatin and Its Derivatives. Acta Pharm., 55(1),27-46
  2. Vine, K.L., Matesic, L., Locke, J.M., Ranson, M., Skropeta, D. 2009. Cytotoxic and Anticancer Activities of Isatin and Its Derivatives: A Comprehensive Review from 2000-2008. Anticancer Agents in Med.Chem., 9(4), 397-414. DOI: 10.2174/1871520610909040397 [3] Phogat, P., Singh, P. 2015. A Mini Review on Central Nervous System Potential of Isatin Derivatives. Cent Nerv Syst Agents Med Chem.,15(1),28-31
  3. Rawat P, Verma SM. 2016. Design and Synthesis of Chroman Derivatives with Dual Anti-Breast Cancer and Antiepileptic Activities. Drug Design, Development and Therapy, 10,2779-2788
  4. Kahveci. B. 2005. Synthesis of 4-Amino-4,5-Dihydro-1H-1,2,4-Triazole-5-Ones and Their Isatin-3-Imine Derivatives. Molecules, 10, 376-382
  5. Sridhar, S.K., Saravanan, M., Ramesh, A. 2001. Synthesis and Antibacterial Screening of Hydrazones, Schiff and Mannich Bases of Isatin Derivatives. Eur J Med Chem., 36(7-8),615-625
  6. Shuttleworth, S.J., Nasturica, D., Gervais, C., Siddiqui, M.A., Rando, R.F., Lee, N. 2000. Parallel Synthesis of Isatin-Based Serine Protease İnhibitors. Bioorg Med Chem Lett., 20,10(22),2501-4
  7. Hamaue, N., Minami, M., Hirafuji, M., Terado, M., Machida, M., Yamazaki, N., Yoshioka, M., Ogata, A., Tashiro, K. 1999. Isatin, an Endogenous MAO Inhibitor, as a New Biological Modulator. CNS Drug Reviews, 5(4), 331-346
  8. Azizian,J., Mohammadi, M.K., Firuzi, O., Razzaghi-asl,N., Miri,R. 2012. Synthesis, Biological Activity and Docking Study of Some New Isatin Schiff Base Derivatives. Med. Chem Res., 21,3730-3740
  9. El-Ossaily, Y. A., Zaki, R. M., Metwally, S. A. 2014. Investigation and Synthesis of Some Novel Spiro Heterocycles Related to Indoline Moiety. J. Sci. Res., 6(2), 293-307
  10. Chinnasamy, R.P., Sundararajan, R., Govindaraj, S. 2010. Synthesis, Characterization, and Analgesic Activity of Novel Schiff Base of Isatin Derivatives. Journal of Advanced Pharmaceutical Technology & Research.,1(3),342-347. doi:10.4103/0110-5558.72428
  11. Sharma, A., Rajyaguru, C., Upadhyay, J.M., Shah, M.K. 2013. Synthesis and Biological Activity of Some New Schiff Bases. Int. J. Chem. Sci.: 11(2), 2013, 981-988
  12. More, P.G., Bhalvankar, R.B., Pattar, S.C. 2001. Synthesis and Biological Activities of Schiff Bases of Aminothiazoles. J. Indian Chem. Soc., 78, 474-475
  13. El-Masry, A.H., Fahmy, H.H., Abdelwahed, S.H.A