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Journals / PTT Hastanesi Tıp Dergisi / 2002 / Cilt: 24 - Sayı: 3

The significance of microalbuminuria to identify coronary artery in type 2 diabetics

Tip 2 diabetes mellituslu hastalarda mikroalbüminürinin koroner arter hastalığını belirlemedeki önemi

AHMET UYANIKOĞLU
Ekrem YAŞAR
Refik DEMİRTUNÇ
Pages
127–132
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Our data suggest that microalbuminuria represents an independent risk factor for coronary artery disease.

📌 3 Key Takeaways

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Objective & Hypothesis:Microalbuminuria is thought to be a marker not only for diabetic nephropathies but also for cardiovascular diseases.
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Key Findings & Data:In this study we investigated whether there were any relationships between microal-buminuria and coronary artery disease and other risk factors in in type 2 diabetics.
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Conclusion & Impact:Conclusion: Our data suggest that microalbuminuria represents an independent risk factor for coronary artery disease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Risk faktörleri · Albüminüri · Diabetes mellitus

Abstract

Microalbuminuria is thought to be a marker not only for diabetic nephropathies but also for cardiovascular diseases. In this study we investigated whether there were any relationships between microal-buminuria and coronary artery disease and other risk factors in in type 2 diabetics. Patients and Methods: The study included 77 patients (36 males, 41 females; mean age 56 years; range 16 to 76 years) with type 2 diabetes mellitus. Urinary excretion of albumin was measured by an immunoturbidimetric method. Microalbuminuria was detected in 51 patients (mean age 53 years), and 26 patients (mean age 57 years) were regarded as non-albuminuric. Serum levels of total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycéride, fasting and postprandial blood sugar, blood urea nitrogen, creatinine clearance, uric acid, and lipoprotein (a) were measured. Results: In the microalbuminuric group, glycosylated hemoglobin (HbA10) levels were significantly higher (p<0.05). No significant differences were found between the two patient groups with regard to hypertension, serum lipids, fasting and postprandial blood sugar, body mass index, uric acid, creatinine clearance, family history of diseases, and the presence of retinopathy (p>0.05). There was a weak correlation between microalbuminuria and total cholesterol levels. Lipoprotein (a) levels did not differ between the two groups. Conclusion: Our data suggest that microalbuminuria represents an independent risk factor for coronary artery disease.

Özet

Mikroalbüminürinin sadece diyabetik nefropati değil aynı zamanda kardiyovasküler hastalıklar için de bir gösterge olabileceği düşünülmektedir. Bu çalışmada tip 2 diabetes mellituslu hastalarda, mikroalbüminüri ile koroner arter hastalığı (KAH) ve bilinen diğer risk faktörleri arasında ilişki olup olmadığını araştırdık. Hastalar ve Yöntemler: Çalışmaya tip 2 diyabetli 77 hasta (36 erkek, 41 kadın; ört. yaş 56, dağılım 16-76) alındı. Albüminüri düzeyleri, 24 saatlik idrarda immünturbidimetrik yöntemle ölçülerek hastalarda mikroalbüminüri bulunup bulunmadığı belirlendi. Elli bir hastada (ört. yaş 53) mikroalbüminüri saptandı; 26 hasta (ört. yaş 57) non-albüminürik grupta yer aldı. Tüm hastalarda total kolesterol, LDL-kolesterol, HDLkolesterol, trigliserid, açlık ve tokluk kan şekeri, kan üre azotu, kreatinin klirensi, ürk asit ve Iipoprotein (a) serum düzeylerine bakıldı. Bulgular: Mikroalbüminürili grupta glikolize hemoglobin (HbA10) değerleri diğer gruba göre anlamlı derecede yüksek bulundu (p 0.05). Mikroalbüminüri ile yalnızca total kolesterol arasında zayıf bir kolerasyon saptandı. Lipoprotein (a) düzeyleri bakımından iki grup arasında anlamlı fark bulunamadı (p>0.05). Sonuç: Mikroalbüminürinin, koroner arter hastalığının bilinen risk faktörlerinden bağımsız olarak risk faktörü oluşturduğu sonucuna varıldı.

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Cite This Article

UYANIKOĞLU, A., YAŞAR, E., DEMİRTUNÇ, R. (2002). The significance of microalbuminuria to identify coronary artery in type 2 diabetics. PTT Hastanesi Tıp Dergisi, Cilt: 24 - Sayı: 3, 127–132. https://ajindex.com/articles/308680

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