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Journals / Politeknik Dergisi / 2019 / Cilt: 22 - Sayı: 4

Preparation of Chitosan and Glycol Chitosan Coated Magnetic Nanoparticles Loaded with Carboplatin as Anticancer Drug

Ceren ATİLA DİNÇER
Ali Mert ERDEK
Ayşe KARAKEÇİLİ
Nuray YILDIZ
Pages
1017–1022
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Fe3O4-OA-GCS-CPt nanocomposites showed higher cytotoxicity than free CPt on the MCF-7 cells at 50 µg/ml drug concentrations during 72 h.

📌 3 Key Takeaways

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Objective & Hypothesis:Surface modified Fe3O4 nanoparticles (Fe3O4-OA) with an average diameter of 10 nm were synthesized, coated by chitosan (CS) and glycol chitosan (GCS), thus magnetic polymer nanocomposites were obtained.
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Key Findings & Data:Loading carboplatin (CPt) as anticancer drug to Fe3O4-OA-GCS nanocomposites were carried out with 13.17 % drug content and 38 % encapsulation efficiency.
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Conclusion & Impact:Fe3O4-OA-GCS-CPt nanocomposites showed higher cytotoxicity than free CPt on the MCF-7 cells at 50 µg/ml drug concentrations during 72 h.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Fe3O4-OA nanoparticles · chitosan / glycol chitosan coating · carboplatin

Abstract

Surface modified Fe3O4 nanoparticles (Fe3O4-OA) with an average diameter of 10 nm were synthesized, coated by chitosan (CS) and glycol chitosan (GCS), thus magnetic polymer nanocomposites were obtained. The magnetic nanostructures were analyzed by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), X-Ray diffraction (XRD) and vibrating sample magnetometer (VSM). All magnetic structures synthesized in this study exhibited superparamagnetic properties. Loading carboplatin (CPt) as anticancer drug to Fe3O4-OA-GCS nanocomposites were carried out with 13.17 % drug content and 38 % encapsulation efficiency. The cytotoxicity studies were occured by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on L929 mouse fibroblasts and MCF-7 human breast cancer cells. Fe3O4-OA-GCS-CPt nanocomposites showed higher cytotoxicity than free CPt on the MCF-7 cells at 50 µg/ml drug concentrations during 72 h.

Özet

Surface modified Fe3O4 nanoparticles (Fe3O4-OA) with an average diameter of 10 nm were synthesized, coated by chitosan (CS) and glycol chitosan (GCS), thus magnetic polymer nanocomposites were obtained. The magnetic nanostructures were analyzed by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), X-Ray diffraction (XRD) and vibrating sample magnetometer (VSM). All magnetic structures synthesized in this study exhibited superparamagnetic properties. Loading carboplatin (CPt) as anticancer drug to Fe3O4-OA-GCS nanocomposites were carried out with 13.17 % drug content and 38 % encapsulation efficiency. The cytotoxicity studies were occured by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on L929 mouse fibroblasts and MCF-7 human breast cancer cells. Fe3O4-OA-GCS-CPt nanocomposites showed higher cytotoxicity than free CPt on the MCF-7 cells at 50 µg/ml drug concentrations during 72 h.

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Cite This Article

DİNÇER, C. A., ERDEK, A. M., KARAKEÇİLİ, A., YILDIZ, N. (2019). Preparation of Chitosan and Glycol Chitosan Coated Magnetic Nanoparticles Loaded with Carboplatin as Anticancer Drug. Politeknik Dergisi, Cilt: 22 - Sayı: 4, 1017–1022. https://ajindex.com/articles/307104

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