Journals / Respiratory Case Reports / 2018 / Cilt: 7 - Sayı: 1

What, Where and How in Granulomatous Diseases?

Granülomatöz Hastalıklarda Ne, Nerede ve Nasıl?

Pages
41–46
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These cases are interesting in that granulomatous diseases may have similarities in clinical, radiological, and pathological features, and repetition of tuberculosis microbiological examination is important in the differential diagnosis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Granulomatous diseases of the lung may be difficult to diagnose in both pathological and clinical aspects.
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Key Findings & Data:Here, 2 cases of granulomatous lung disease that had been incorrectly diagnosed are described.
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Conclusion & Impact:These cases are interesting in that granulomatous diseases may have similarities in clinical, radiological, and pathological features, and repetition of tuberculosis microbiological examination is important in the differential diagnosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Granulomatous diseases of the lung may be difficult to diagnose in both pathological and clinical aspects. The most common reasons for granulomatous lung are tuberculosis as an infectious source, and sarcoidosis or hypersensitivity pneumonia (HP) as non-infectious causes. Here, 2 cases of granulomatous lung disease that had been incorrectly diagnosed are described. The first was a 64-year-old female patient diagnosed as HP clinically and radiologically, and the second was a 67-year-old male diagnosed as sarcoidosis pathologically. Both had progression clinically and radiologically under corticosteroid treatment. Repeat bronchoscopic evaluation revealed Mycobacterium tuberculosis in the bronchial lavage polymerase chain reaction/BACTEC (Becton Dickinson and Co., Franklin Lakes, NJ, USA) cultures, and lung tuberculosis treatment was initiated for both patients. These cases are interesting in that granulomatous diseases may have similarities in clinical, radiological, and pathological features, and repetition of tuberculosis microbiological examination is important in the differential diagnosis.

Özet

Akciğerin granülomatöz hastalıkları patolojik ve klinik açıdan ayırt edici tanısı zor olabilen durumlardır. Enfeksiyon dışı nedenlerden sarkoidoz, hipersensitivite pnömonisi ve enfeksiyöz olarak ise tüberküloz en sık görülenleridir. Burada granülomatöz akciğer hastalığı olup ayırt edici tanılarında zorluk yaşanan olgular uzun süreli takipleriyle sunuldu. Birinci olgu 64 yaşında kadın hasta, klinik ve radyolojik olarak hipersensitivite pnömonisi ve ikinci olgu ise 67 yaşında erkek hasta, patolojik olarak sarkoidoz ön tanıları konularak kortikosteroid kullanmaktaydı. Ancak, kortikosteroid altında klinik ve radyolojik progresyon olması üzerine yeniden tanısal araştırma yapıldı. Tekrarlanan bronkoskopik örneklemelerle ve farklı (PCR/BACTEC) tüberküloz kültürü yöntemleri kullanılarak Mycobacterium tuberculosis üremesi olması ile akciğer tüberkülozu tedavisi verildi. Sonuç olarak, bu olgular granülomatöz hastalıkların klinik, radyolojik ve patolojik açıdan benzerlik gösterebileceğini ve ayırt edici tanıda tüberküloz mikrobiyolojik tetkik tekrarının önemini göstermesi açısından ilginçtir.

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Cite This Article

OYMAN, T. G., ALTAN, G., BAÇÇIOĞLU, A., KALPAKLIOĞLU, A. F. (2018). What, Where and How in Granulomatous Diseases?. Respiratory Case Reports, Cilt: 7 - Sayı: 1, 41–46. https://ajindex.com/articles/302440

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