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Journals / Mikrobiyoloji Bülteni / 2008 / Cilt: 42 - Sayı: 3

High rate of hepatitis B virus DNA positivity in anti-HBc only-positive patients

İzole anti-HBc pozitif hastalarda saptanan yüksek hepatit B virusu DNA oranı

Mustafa YILDIRIM
M. Tevfik YAVUZ
Davut ÖZDEMİR
Mustafa BEHÇET
İrfan ŞENCAN
Pages
535–536
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was concluded that there may be a serious risk of HBV transmission from anti-HBc only-positive patients since the rate of HBV-DNA positivity was found high in our study.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In hepatitis B virus (HBV) infections, detection of only anti-HBc in the absence of HBsAg and anti-HBs is known as 'anti-HBc only' situation.
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Key Findings & Data:In this study we investigated the rate of HBV-DNA positivity in anti-HBc only-positive 45 patients (29 male, 16 female; mean age: 39.2 ±12.3 years) who were followed in the outpatient clinics of a University Hospital in Düzce (located at northern west part of Turkey).
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Conclusion & Impact:It was concluded that there may be a serious risk of HBV transmission from anti-HBc only-positive patients since the rate of HBV-DNA positivity was found high in our study.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Hepatit B · DNA · Hepatit B kor antijenleri

Abstract

In hepatitis B virus (HBV) infections, detection of only anti-HBc in the absence of HBsAg and anti-HBs is known as 'anti-HBc only' situation. In this study we investigated the rate of HBV-DNA positivity in anti-HBc only-positive 45 patients (29 male, 16 female; mean age: 39.2 ±12.3 years) who were followed in the outpatient clinics of a University Hospital in Düzce (located at northern west part of Turkey). HBV markers were investigated by 3rd generation ELISA (MEIA Axsym-Abbott), and HBV-DNA were searched by real-time PCR [extraction: Minielute (Qiagen, Germany); PCR kits: Florion HBV (lontek, Turkey); detection: i-cycler IQ5 (BioRad, USA)] methods. As a result, 24.4% (11/45) of the patients were found HBV-DNA positive (> 103 copies/ml). There was no statistically significant difference of HBV-DNA positivity rates between males (9/29; 31 %) and females (2/16; 12.5%), (p= 0.15). It was concluded that there may be a serious risk of HBV transmission from anti-HBc only-positive patients since the rate of HBV-DNA positivity was found high in our study. Thus HBV-DNA screening should be performed in 'anti-HBc only' patient groups

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Cite This Article

YILDIRIM, M., YAVUZ, M. T., ÖZDEMİR, D., BEHÇET, M., ŞENCAN, İ. (2008). High rate of hepatitis B virus DNA positivity in anti-HBc only-positive patients. Mikrobiyoloji Bülteni, Cilt: 42 - Sayı: 3, 535–536. https://ajindex.com/articles/299000

References (9)

  1. Wright TL, Terrault NA, Ganem D. Hepatitis B virus, pp: 633-81. In: Hichman DO, Whitley RJ, Hayden FG (eds), Clinical Virology. 1997. Churchill Livingstone Inc, UK
  2. Badur S. Hepatit B virusu (HBV) moleküler viroloji ve serolojik tanı, s: 65-90. Kılıçturgay K (ed), Viral Hepatit 94. 1994, Viral Hepatitle Savaşım Derneği, İstanbul
  3. Mert A, Şentürk H, Süve I ve ark. HBsAg ve anti-HBs negatif, anti-HBc pozitif olguların çeşitli yönlerden incelenmesi. Viral Hepatit Dergisi 1996; 2: 92-5
  4. Allain ]P, Hewitt PE, Tedder RS, Williamson LM. Evidence that anti-HBc but not HBV DNA testing may prevent some HBV transmission by transfusion. Br J Haematol 1999; 107: 186-95
  5. Altunay H, Kenar S, Koçak N, Çavuşlu Ş. İzole anti-HBc pozitifliğinde hepatit B virüs infeksiyözitesinin araştırılması. Viral Hepatit Dergisi 2003; 8: 10-5
  6. Berger A, Doerr HW, Rabenau HF, Weber B. High frequency of HCV infection in individuals with isolated antibody to hepatitis B core antigen. Intervirology 2000; 43: 71-6
  7. Alhababi F, Sallam TA, Tong CY. The significance of 'anti-HBc only' in the clinical virology laboratory. J Clin Virol 2003;27:162-9
  8. El-Zaatari M, Kazma H, Naboulsi-Majzoub M, et al. Hepatitis B virus DNA in serum of 'anti-HBc only'positive healthy Lebanese blood donors: significance and possible implications.J Hosp Infect 2007; 66: 278-82
  9. Chaudhuri V, Nanu A, Panda SK, Chand P. Evaluation of serologic screening of blood donors in India reveals a lack of correlation between anti-HBc titer and PCR-amplified HBV DNA. Transfusion 2003; 43: 1442-8.