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Journals / Mikrobiyoloji Bülteni / 2008 / Cilt: 42 - Sayı: 1

Helicobacter pylori infection and phagocytosis

Helicobacter pylori enfeksiyonu ve fagositoz

EBRU DEMİRAY GÜRBÜZ
Neslihan BEKMEN
Pages
177–184
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review article, the correlation between H.pylori infection and innate immune response with emphasis on the avoidance of killing by phagocytosis, have been discussed.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Helicobacter pylori is a chronic infectious agent defined as the major pathogen causing gastritis, gastric and duodenal ulcer, gastric carcinoma and mucosa associated lenfoid tissue (MALT) lymphoma.
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Key Findings & Data:H.pylori is the only microorganism known to get colonized in human stomach and inhabit in gastric mucosal cells.
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Conclusion & Impact:In this review article, the correlation between H.pylori infection and innate immune response with emphasis on the avoidance of killing by phagocytosis, have been discussed.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Helicobacter pylori is a chronic infectious agent defined as the major pathogen causing gastritis, gastric and duodenal ulcer, gastric carcinoma and mucosa associated lenfoid tissue (MALT) lymphoma. H.pylori is the only microorganism known to get colonized in human stomach and inhabit in gastric mucosal cells. To achieve this, H.pylori must escape from both innate and adaptive immune responses. The host immune response is unable to eliminate the infection and this is generally associated with pathogenesis. The persistence of the induced H.pylori infection suggests that the response is not effective to eliminate the infection. In this review article, the correlation between H.pylori infection and innate immune response with emphasis on the avoidance of killing by phagocytosis, have been discussed.

Özet

Helicobacter pylori gastrit, gastrik ve duodenal ülserler, gastrik karsinoma ve mukoza ile ilişkili lenfoid doku (MALT) lenfomasında temel patojen olarak tanımlanmış kronik enfeksiyon etkeni olan bir bakteridir. H.pylori midede kolonize olabilen tek mikroorganizmadır ve gastrik mukus salgılayan hücrelerde yerleşme özelliğine sahiptir. Bunun için hem doğal hem de kazanılmış bağışık yanıt mekanizmalarından kaçması gerekmektedir. Konağın bağışık yanıtı, enfeksiyonu yok edememekte ve ilginç olarak da patogenezle ilişkilendirilmektedir. Enfeksiyon varlığında oluşan yanıtın enfeksiyonu yok etmede etkili olmadığı düşünülmektedir. Bu derleme yazıda, H.pylori enfeksiyonu ve doğal bağışık yanıt arasındaki ilişki ile bakterinin fagositozdan kaçış mekanizmaları tartışılmıştır.

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Cite This Article

GÜRBÜZ, E. D., BEKMEN, N. (2008). Helicobacter pylori infection and phagocytosis. Mikrobiyoloji Bülteni, Cilt: 42 - Sayı: 1, 177–184. https://ajindex.com/articles/298989

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