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Journals / Mikrobiyoloji Bülteni / 2012 / Cilt: 46 - Sayı: 4

An overview on trichosporon asahii and its infections

Trichosporon asahii ve enfeksiyonlarına genel bakış

GÜLŞEN HAZIROLAN
Pages
707–715
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review article general characteristics of T.asahii and its infecti- ons were summarized.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Trichosporon species cause systemic, mucosa associated and superficial infections which include white piedra.
📊
Key Findings & Data:Disseminated fungal infections due to Trichosporon species have increased in the recent years.
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Conclusion & Impact:In this review article general characteristics of T.asahii and its infecti- ons were summarized.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Trichosporon species cause systemic, mucosa associated and superficial infections which include white piedra. Disseminated fungal infections due to Trichosporon species have increased in the recent years. Hematologic malignancy, cytotoxic chemotherapy, and organ transplantation are the main risk factors for disseminated Trichosporon infections. Two most common species that cause the disseminated Trichosporon infections are Trichosporon asahii and Trichosporon mucoides. Diagnosis and treatment of Trichosporon infections are difficult. Invasive trichosporonosis caused by T.asahii has a high mortality rate and a very poor prognosis. Fungicidal activity of amphotericin B against T.asahii isolates is inadequate. For echinocandin group of drugs, high minimum inhibitory concentration (MIC, μg/ml) values are obtained. Currently, triazole antifungal agents are the preferred drugs for the treatment of Trichosporon infections. In this review article general characteristics of T.asahii and its infecti- ons were summarized.

Özet

Trichosporon türleri, sistemik veya mukoza ile ilişkili ya da beyaz piedrayı da içine alan yüzeyel enfeksiyonlara sebep olabilir. Trichosporon türlerine bağlı gelişen invazif enfeksiyonlarda son yıllarda artış gözlenmiştir. Hematolojik malignansi, sitotoksik kemoterapi ve organ transplantasyonu, invazif Trichosporon enfeksiyonları için başlıca risk faktörleridir. İnvazif trikosporonoza en sık neden olan türler Trichosporon asahii ve Trichosporon mucoides’dir. Trichosporon enfeksiyonlarının tanısı ve tedavisi zordur. T.asahii’nin neden olduğu invazif trikosporonoz yüksek mortalite oranı ve kötü prognozuyla hayatı tehdit edici bir enfeksiyondur. Amfoterisin B’nin T.asahii izolatlarına karşı fungusidal aktivitesi genellikle yetersizdir. Ekinokandin grubu ilaçlar için ise, Trichosporon izolatlarında yüksek minimum inhibitör konsantrasyonu (MİK, μg/ml) değerleri elde edilmektedir. Triazol grubu antifungaller, Trichosporon enfeksiyonlarının tedavisinde tercih edilen ilaçlardır. Bu derleme yazıda, T.asahii ve enfeksiyonlarının genel özellikleri özetlen- miştir.

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Cite This Article

HAZIROLAN, G. (2012). An overview on trichosporon asahii and its infections. Mikrobiyoloji Bülteni, Cilt: 46 - Sayı: 4, 707–715. https://ajindex.com/articles/298653

References (13)

  1. Taj-Aldeen SJ, Al-Ansari N, El Shafei S, et al. Molecular identification and susceptibility of Trichosporon spe- cies isolated from clinical specimens in Qatar: isolation of Trichosporon dohaense Taj-Aldeen, Meis & Boek- hout sp. nov. J Clin Microbiol 2009; 47(6): 1791-9
  2. Nanthawan M, Takashi S, Reiko I. Genotyping and antifungal drug susceptibility of the pathogenic yeast Trichosporon asahii isolated from Thai patients. Mycopathologia 2010; 169(1): 67-70
  3. Kalkanci A, Sugita T, Arikan S, et al. Molecular identification, genotyping, and drug susceptibility of the ba- sidiomycetous yeast pathogen Trichosporon isolated from Turkish patients. Med Mycol 2010; 48(1): 141-6
  4. Chagas-Neto TC, Chaves GM, Colombo AL. Update on the genus Trichosporon. Mycopathologia 2008; 166(3): 121-32
  5. Gueho E, de Hoog GS, Smith MT. Neotypification of the genus Trichosporon. Antonie Van Leeuwenhoek 1992; 61(4): 285-8
  6. Gueho E, Smith MT, de Hoog GS, Billon-Grand G, Christen R, Batenburg-van der Vegte WH. Contributions to a revision of the genus Trichosporon. Antonie Van Leeuwenhoek 1992; 61(4): 289-316
  7. Basiri K, Meidani M, Rezaie F, Soheilnader S, Fatehi F. A rare case of Trichosporon brain abscess, successfully treated with surgical excision and antifungal agents. Neurol Neurochir Pol 2012; 46(1): 92-5
  8. Sugita T, Nishikawa A, Shinoda T. Reclassification of Trichosporon cutaneum by DNA relatedness by using the spectrophotometric method and chemiluminometric method. J Gen Appl Microbiol 1994; 40(5): 397- 408
  9. Sugita T, Nishikawa A, Shinoda T, Kume H. Taxonomic position of deep-seated, mucosa associated, and superficial isolates of Trichosporon cutaneum from trichosporonosis patients. J Clin Microbiol 1995; 33(5): 1368-70
  10. Middelhoven WJ, Scorzetti G, Fell JW. Systematics of the anamorphic basidiomycetous yeast genus Trichosporon Behrend with the description of five novel species: Trichosporon vadense, T.smithiae, T.dehoogii, T.scarabaeorum and T.gamsii. Int J Syst Evol Microbiol 2004; 54(Pt 3): 975-86
  11. Sugita T, Ikeda R, Nishikawa A. Analysis of Trichosporon isolates obtained from the houses of patients with summer-type hypersensitivity pneumonitis. J Clin Microbiol 2004; 42(12): 5467-71
  12. Colombo AL, Padovan AC, Chaves GM. Current knowledge of Trichosporon spp. and trichosporonosis. Clin Microbiol Rev 2011; 24(4): 682-700
  13. Girmenia C, Pagano L, Martino B, et al; GIMEMA Infection Program. Invasive infections caused by Trichosporon species and