Journals / Mikrobiyoloji Bülteni / 2012 / Cilt: 46 - Sayı: 1

A case of Crimean-Congo hemorrhagic fever with long incubation period in Kocaeli, Turkey

Kocaeli'de uzun inkübasyon süreli sporadik Kırım-Kongo kanamalı ateşi olgusu

Pages
129–133
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This case was presented to withdraw attention to a long incubation period CCHF and also of its epidemiological importance since it was the first case in Kocaeli province, Turkey.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Crimean-Congo hemorrhagic fever (CCHF) is a viral hemorrhagic disease with high mortality rate.
📊
Key Findings & Data:The incubation period of the disease is between 1-3 days (maximum 12 days).
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Conclusion & Impact:This case was presented to withdraw attention to a long incubation period CCHF and also of its epidemiological importance since it was the first case in Kocaeli province, Turkey.
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Hemorrhagic Fever Virus · Crimean-Congo · Kanamalı ateş

Abstract

Crimean-Congo hemorrhagic fever (CCHF) is a viral hemorrhagic disease with high mortality rate. CCHF is endemic in Central Anatolia and East and Central Black Sea parts of Turkey, however sporadic cases have been detected in the other regions. The incubation period of the disease is between 1-3 days (maximum 12 days). In this report, a very rare CCHF case with a long incubation period of 30 days, was reported. A 40-year-old female patient living in a village of Kocaeli, Turkey was admitted to a health center in June 2010 with the complaints of headache, myalgia, nausea, vomiting, fatigue and fever. Since laboratory results revealed severe thrombocytopenia (18.300/mm3), the patient was referred to the university hospital in Kocaeli. It was learned from her history that she had been working in the garden and removed a tick from the skin of gluteal area a month ago without seeking any medical help. Physical examination of the patient revealed that her general condition was well, oriented and cooperative, body temperature was 36.6°C, pulse 82/minute, trombocyte count 69.400/mm3 and liver enzymes were elevated (ALT: 194 U/L, AST: 499 U/L, GGT: 384 U/L, LDH: 1290 U/L). Petecchial lesions were seen on hard palate and extremities and a hyperemic lesion was detected at the gluteal area where the tick had attached. In-house real-time polymerase chain reaction test for CCHF, performed at Refik Saydam National Public Health Agency, Virology Reference and Research Laboratory, revealed positive result. This case was presented to withdraw attention to a long incubation period CCHF and also of its epidemiological importance since it was the first case in Kocaeli province, Turkey.

Özet

Kırım-Kongo kanamalı ateşi (KKKA), yüksek mortalite hızına sahip viral kanamalı bir hastalıktır. Ülkemizde KKKA, İç Anadolu, Doğu ve Orta Karadeniz bölgelerinde endemik, diğer bölgelerde ise sporadik olarak görülmektedir. Hastalığın inkübasyon süresi 1-3 gün (maksimum 12 gün) arasında bildirilmektedir. Bu raporda, 30 günlük uzun bir inkübasyon dönemi sonrasında ortaya çıkan bir KKKA olgusu sunulmaktadır. Kocaeli’nin Kandıra ilçesi Alabey Köyü’nde yaşayan 40 yaşında kadın hasta, Haziran 2010 tarihinde baş ağrısı, kas ağrısı, bulantı, kusma, halsizlik ve ateş şikayetleriyle bir sağlık kurumuna başvurmuş, ciddi trombositopeni (18.300/mm3) nedeniyle hastanemize sevk edilmiştir. Hastanın öyküsünden, bahçe işlerinde çalıştığı ve bir ay önce kalçasına kene yapıştığını fark ederek keneyi çıkarıp attığı, ancak herhangi bir sağlık kuruluşuna başvurmadığı belirlenmiştir. Hastanemizde yapılan değerlendirmede genel durumunun iyi, oryante ve koopere olduğu, vücut sıcaklığının 36.6°C, nabız hızının 82/dakika, trombosit sayısının 69.400/mm3 ve karaciğer enzim düzeylerinin yüksek olduğu (ALT: 194 U/L, AST: 499 U/L, GGT: 384 U/L, LDH: 1290 U/L) saptanmıştır. Fizik muayenede, sert damak ve ekstremitelerde peteşiyel lezyonlar izlenmiş; kenenin tutunduğu gluteal bölgede hiperemik lezyon tespit edilmiştir. KKKA tanısı, Refik Saydam Hıfzıssıhha Merkezi Başkanlığı, Viroloji Referans Laboratuvarına gönderilen serum örneğinde “in-house real-time” polimeraz zincir reaksiyonu ile pozitif sonuç alınmasıyla konulmuştur. Bu olgu, uzun inkübasyon dönemli olmasının yanı sıra, Kocaeli’de tespit edilen ilk KKKA olgusu olması açısından da epidemiyolojik önem taşıması nedeniyle sunulmaya değer bulunmuştur.

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Cite This Article

KOÇ, M. M., WILLKE, A. (2012). A case of Crimean-Congo hemorrhagic fever with long incubation period in Kocaeli, Turkey. Mikrobiyoloji Bülteni, Cilt: 46 - Sayı: 1, 129–133. https://ajindex.com/articles/298651

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