Journals / MN Oftalmoloji / 2005 / Cilt: 12 - Sayı: 3

The evaluation of serum homocystein levels in patients with pseudoexfoliation glaucoma

Psödoeksfoliasyon glokomlu olgularda serum homosistein düzeylerinin değerlendirilmesi

Pages
258–259
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

However, in our study no correlation were found between homocystein levels and pseudoexfoliation.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Purpose: Evaluation of serum homocystein levels in patients with pseudoexfoliation glaucoma Material and Methods: 25 pseudoexfoliation glaucoma patients and 17 control patients were included in the study.
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Key Findings & Data:Venous blood samples that were collected after 12 hours of starving were sentrifuged and serum homocystein levels were studied by high performance liquid chromatography (HPLC) method.
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Conclusion & Impact:However, in our study no correlation were found between homocystein levels and pseudoexfoliation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Eksfoliasyon sendromu · Glokom · Homosistein

Abstract

Purpose: Evaluation of serum homocystein levels in patients with pseudoexfoliation glaucoma Material and Methods: 25 pseudoexfoliation glaucoma patients and 17 control patients were included in the study. The patients were questioned for systemic disorders that could effect their serum homocystein levels and inappropriate patients were excluded. Venous blood samples that were collected after 12 hours of starving were sentrifuged and serum homocystein levels were studied by high performance liquid chromatography (HPLC) method. Serum homocystein levels of 5.5-17 mmol/L were taken as normal. Results: The patients with pseudoexfoliation glaucoma had a median age of 68.1±5.9 years and the control group had a median of 68.7±7.4 years. Serum homocystein levels were 13.707 mmol/L±5.481 in pseudoexfoliation glaucoma patients and 16.248 mmol/L±6.369 in the control group. There were no difference in age distribution and serum homocystein levels between two groups. Conclusion: Studies of determining the higher risk of vascular disease in pseudoexfoliation syndrome have been going on. However, in our study no correlation were found between homocystein levels and pseudoexfoliation.

Özet

Amaç: Psödoeksfoliasyon glokomlu olgularda serum homosistein düzeylerinin değerlendirilmesi Gereç ve Yöntem: Klinikte takip edilen ve poliklinikte görülen 25 psödoeksfoliasyon glokomlu, 17 gözlerinde psödoeksfoliasyon olmayan hasta çalışmaya dahil edildi. Hastaların tüm oküler muayeneleri yapıldı. Hastaların homosistein düzeylerini etkileyebilecek sistemik hastalıkları sorgulandı ve uygun olmayan hastalar çalışmaya dahil edilmedi. Oniki saat açlığı takiben alınan venöz kan örnekleri sentrifüje edilerek serum homosistein düzeyleri yüksek perfomans likit kromatografi (HPLC) yöntemi ile çalışıldı. Serum homosistein düzeyi 5.5-17 mmol/L arası normal kabul edildi. Bulgular: PSX glokomu olan yaş ortalamaları 68.1±5.9 yıl, kontrol grubunda 68.7±7.4 yıl idi. Serum homosistein düzeyleri glokomlu hastalarda 13.707 mmol/L±5.481, kontrol grubunda 16.248 mmol/L±6.369 olarak elde edildi. Gruplar arasında yaş ortalamaları ve homosistein düzeyleri açısından anlamlı fark gözlenmedi. Sonuç: Psödoeksfoliasyon sendromu ile beraber artmış vasküler hastalık riskini açıklamaya yönelik çalışmalar sürmektedir. Ancak bu çalışmada homosistein düzeyleri ile psödoeksfoliasyon arasında bağlantı saptanmamıştır.

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Cite This Article

GERİBEYOĞLU, L., SÜRER, H., EVREN, Ö., ÖĞÜŞ, E., GÜRSEL, E. (2005). The evaluation of serum homocystein levels in patients with pseudoexfoliation glaucoma. MN Oftalmoloji, Cilt: 12 - Sayı: 3, 258–259. https://ajindex.com/articles/297074

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References (7)

  1. Ritch R, Schlötzer-Schrehardt U. Exfoliation Sydrome. Surv Ophtalmol 2001; 45:265-315
  2. Amari F, Nagata S, Umihira J. Lectin electron microscopic histochemistry of the pseudoexfoliative material in the skin. Invest Ophtalmol Vis Sci 1994; 35:3962-6
  3. Schlötzer-Schrehardt UM,Koca MR, Naumann GO.Volkholz H. Pseudoexfoliation syndrome. Ocular manifestation of a systemic disorder? Arch Ophtalmol 1992; 110:1752-6
  4. Streeten BW, Li Z-Y, Wallace RN, Eagle RC, Keshgegian AA. Pseudoexfoliative fibrillopathy in visceral organs of a patient with pseudoexfoliation syndrome. Arch Opthalmol 1992; 110:1757-62
  5. Fauci A, Braunwald E, Isşelbacher K, et al. Homocystinurias. Harrison's Principles of Internal Medicine. 14th Edition. Volume 2; 2199-201
  6. Vine AK. Hyperhomocysteinemia: a risk factor for central retinal vein occlusion. Am J Opthalmol 2000; 107:1588-92
  7. Leibovitch L, Kurtz S, Shemens G, et al. Hyperhomocystinemi-a in Pseudoexfoliation Glaucoma. J Glaucoma 2003; 12:36-9.